Lenvatinib versus sorafenib for first-line treatment of unresectable hepatocellular carcinoma: patient-reported outcomes from a randomised, open-label, non-inferiority, phase 3 trial.

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Hepatocellular carcinoma is the third-leading cause of cancer-related death worldwide. Preservation of health-related quality of life (HRQOL) during treatment is an important therapeutic goal. The aim of this study was […]

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Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms Following Dilation in Adults with Eosinophilic Esophagitis.

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Esophageal dilation improves dysphagia but not inflammation in eosinophilic esophagitis (EoE) patients. We investigated if dilation modifies the association between symptoms and esophageal eosinophil count (eos/hpf).Adults enrolled in a multisite, […]

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Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms Following Dilation in Adults with Eosinophilic Esophagitis.

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Esophageal dilation improves dysphagia but not inflammation in eosinophilic esophagitis (EoE) patients. We investigated if dilation modifies the association between symptoms and esophageal eosinophil count (eos/hpf).Adults enrolled in a multisite, […]

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Psychiatric comorbidities are highly prevalent in non-esophageal eosinophilic gastrointestinal diseases.

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The prevalence of psychiatric comorbidity in non-esophageal eosinophilic gastrointestinal disorders (EGIDs) has not been studied. We aimed to ascertain the prevalence of psychiatric diagnoses and psychiatric medication use in children, […]

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Coexpression gene network analysis reveals novel regulatory pathways involved in porto-sinusoidal vascular disease.

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Porto-sinusoidal vascular disease (PSVD) is a rare vascular liver disease of unknown etiology that causes portal hypertension. It usually affects young individuals and shorts live expectancy. The deregulated pathways involved […]

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GREATER OVERLAP OF ROME IV DISORDERS OF GUT-BRAIN INTERACTIONS LEADS TO INCREASED DISEASE SEVERITY AND POORER QUALITY OF LIFE.

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Conditions such as irritable bowel syndrome (IBS), functional dyspepsia and functional constipation are among the prevalent gastrointestinal disorders classified as disorders of gut brain interaction (DGBI), which can adversely affect […]

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Sorafenib is associated with a reduced rate of tumour growth and liver function deterioration in HCV-induced hepatocellular carcinoma.

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Sorafenib has been the standard of care for patients with advanced hepatocellular carcinoma and although immunotherapeutic approaches are now challenging this position, it retains an advantage in HCV seropositive patients. […]

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CheckMate 040 Cohort 5: A phase I/II study of nivolumab in patients with advanced hepatocellular carcinoma and Child-Pugh B cirrhosis.

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Patients with advanced hepatocellular carcinoma (aHCC) and Child-Pugh B liver function are often excluded from clinical trials. In previous studies, overall survival for these patients treated with sorafenib was ∼3-5 […]

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Characteristics and survival of patients with inflammatory bowel disease and post-colonoscopy colorectal cancers.

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Post-colonoscopy colorectal cancers (PCCRCs) account for up to 50% of colorectal cancers (CRCs) in patients with inflammatory bowel disease (IBD). We investigated characteristics of IBD patients with PCCRC and their […]

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Covalently closed circular DNA: the ultimate therapeutic target for curing Hepatitis B virus infections.

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Current antiviral therapies, such as pegylated interferon alpha and nucleos(t)ide analogs effectively improve the patient’s quality of life. However, they are limited to control the infection but cannot cure infected […]

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Reevaluation of the Cardiovascular Safety Profile of Tegaserod: A Review of the Clinical Data.

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Tegaserod is a 5-HT4 receptor agonist approved for irritable bowel syndrome with constipation in females <65 years without a history of cardiovascular ischemic events.Safety data are presented from two external […]

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Tofacitinib for Biologic-Experienced Hospitalized Patients with Acute Severe Ulcerative Colitis: A Retrospective Case-Control Study.

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Despite rescue therapy, more than 30% of patients with acute severe ulcerative colitis (ASUC) require colectomy. Tofacitinib is a rapidly acting JAK inhibitor with proven efficacy in ulcerative colitis. Tofacitinib […]

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Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction.

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Patients with acutely decompensated cirrhosis have a dismal prognosis and frequently progress to acute-on-chronic liver failure, which is characterised by hepatic and extrahepatic organ failure(s). The pathomechanisms involved in decompensation […]

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The search for disease-modifying agents in decompensated cirrhosis: From drug repurposing to drug discovery.

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Patients with decompensated cirrhosis are currently managed through targeted strategies aimed at preventing or treating specific complications. In contrast, a disease-modifying agent should, by definition, be aimed at globally addressing […]

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Transition to decompensation and acute-on-chronic liver failure: Role of predisposing factors and precipitating events.

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The transition from compensated to decompensated cirrhosis results from a complex interplay of predisposing and precipitating factors and represents an inflection point in the probability of a patient surviving. With […]

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Limitations of current liver donor allocation systems and the impact of newer indications for liver transplantation.

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Liver transplantation represents a life-saving treatment for patients with decompensated cirrhosis, a severe condition associated with a high risk of waiting list mortality. When decompensation occurs rapidly in the presence […]

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Cancer Risk in 47,241 Individuals with Celiac Disease – A Nationwide Cohort Study.

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Celiac disease (CD) is associated with increased mortality, in part due to cancer. Most studies investigating this cancer risk involved patients diagnosed before widespread increases in CD diagnosis rates and […]

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Differential clinical characteristics and mortality outcomes in persons with NAFLD and/or MAFLD.

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Metabolic dysfunction-associated fatty liver disease (MAFLD) establishes new criteria for diagnosing fatty liver disease independent of alcohol intake and concomitant viral hepatitis infection. However, the long-term outcomes of patients with […]

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