Conceptual Model for the Hepatocellular Carcinoma Screening Continuum: Current Status and Research Agenda.

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Hepatocellular carcinoma (HCC) continues to have a dismal prognosis, with 5-year survival below 20%. This poor prognosis can be in part attributed to failures along the cancer screening process continuum […]

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Reduction of squalene epoxidase by cholesterol accumulation accelerates colorectal cancer progression and metastasis.

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Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol biosynthesis, is suggested as a proto-oncogene. Paradoxically, SQLE is degraded by excess cholesterol, and low SQLE is associated with aggressive colorectal cancer […]

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Higher adenoma detection rates at screening associated with lower long-term colorectal cancer incidence and mortality.

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Detection and removal of adenomas reduces colorectal cancer (CRC) risk. The impact of adenoma detection rates (ADRs) on long-term CRC incidence and mortality is unknown. We investigated this using data […]

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Benefits and Harms of Hepatocellular Carcinoma Surveillance in a Prospective Cohort of Patients with Cirrhosis.

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The value of a cancer screening programs is defined by its balance of benefits and harms; however, there are few data evaluating both attributes for hepatocellular carcinoma (HCC) surveillance. We […]

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Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase.

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Streptococcus thermophilus was identified to be depleted in patients with colorectal cancer (CRC) by shotgun metagenomic sequencing of 526 multi-cohort fecal samples. Here, we aim to investigate if this bacterium […]

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RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma.

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Background and Aims Mutational profiling of patient tumors has suggested that hepatocellular carcinoma (HCC) development is mainly driven by loss-of-function mutations in tumor suppressor genes. p90 Ribosomal S6 kinase 2 […]

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TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.

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Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic regenerative processes. The triggering receptor expressed on myeloid […]

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WASh multicentre randomised controlled trial: water-assisted sigmoidoscopy in English NHS bowel scope screening.

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The English Bowel Cancer Screening Programme invites 55 year olds for a sigmoidoscopy (Bowel Scope Screening (BSS)), aiming to resect premalignant polyps, thus reducing cancer incidence. A national patient survey indicated […]

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Impact of SARS-CoV-2 pandemic on colorectal cancer screening delay: effect on stage shift and increased mortality.

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The SARS-CoV-2 pandemic had a sudden, dramatic impact on healthcare. In Italy, since the beginning of the pandemic, colorectal cancer (CRC) screening programs have been forcefully suspended. We aimed to […]

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Adult liver transplantation: A UK clinical guideline – part 1: pre-operation.

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Liver transplantation is a highly successful treatment for all types of liver failure, some non-liver failure indications and liver cancer. Most referrals come from secondary care. This first part of […]

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Diagnostic Yield of Colonoscopy in Patients with Symptoms Compatible with Rome IV Functional Bowel Disorders.

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There is little data on the diagnostic yield of colonoscopy in patients with symptoms compatible with functional bowel disorders (FBDs). Previous studies have only focused on diagnostic outcomes of colonoscopy […]

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Long-term Risks of Parkinson’s Disease, Surgery, and Colorectal Cancer in Patients with Slow-transit Constipation.

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Long-term outcomes of constipation have not been fully evaluated. We investigated the incidences of Parkinson’s disease, constipation-related surgery, and colorectal cancer (CRC) in patients with constipation and slow-transit constipation (STC), […]

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Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.

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ATM serine/threonine kinase (ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), in pancreatic ductal adenocarcinoma (PDAC).Combinational synergy screening was performed to endeavour a […]

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Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study.

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Despite concerns that patients with liver transplants might be at increased risk of adverse outcomes from COVID-19 because of coexisting comorbidities and use of immunosuppressants, the effect of severe acute […]

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Single Cell Transcriptional Analyses Identify Lineage-Specific Epithelial Responses to Inflammation and Metaplastic Development in the Gastric Corpus.

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Chronic atrophic gastritis can lead to gastric metaplasia and increase risk of gastric adenocarcinoma. Metaplasia is a precancerous lesion associated with an increased risk for carcinogenesis, but the mechanism(s) by […]

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Results of Compliant Participation in 5 Rounds of Fecal Immunochemical Test Screening for Colorectal Cancer.

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We investigated the magnitude and temporal patterns of the decreasing trend in main performance measures of fecal immunochemical test (FIT) screening for colorectal cancer (CRC) being observed in second and […]

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CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer.

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Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy. We develop strategies for overcoming IFNG-mediated adaptive immune resistance in pancreatic ductal […]

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Cooperation between distinct cancer driver genes underlies inter-tumor heterogeneity in hepatocellular carcinoma.

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The pattern of genetic alterations in cancer driver genes in patients with hepatocellular carcinoma (HCC) is highly diverse, which partially explains the low efficacy of available therapies. In spite of […]

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In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.

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Mutant KRAS promotes glutaminolysis, a process that uses steps from the tricarboxylic cycle to convert glutamine to α-ketoglutarate and other molecules, via glutaminase and solute carrier family 25 member 22 […]

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Increased mortality in HIV/HCV-coinfected compared to HCV-monoinfected patients in the DAA era due to non-liver-related death.

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Direct acting antivirals (DAA) lead to high sustained virological response (SVR) rates and decreased the risk of disease progression. We compared SVR rates and all-cause, liver- and non-liver-related deaths, liver-related […]

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