Selecting Endpoints for Disease-Modification Trials in Inflammatory Bowel Disease: the SPIRIT consensus from the IOIBD.

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Inflammatory bowel diseases (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), are chronic and disabling disorders. Prospective disease-modification trials to prevent disease progression are eagerly awaited. However, disease progression […]

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Prognostic factors for advanced colorectal neoplasia in inflammatory bowel disease: systematic review and meta-analysis.

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Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer (CRC). We performed a systematic review and meta-analysis to identify all prognostic factors for advanced colorectal neoplasia […]

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STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.

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The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) has proposed treatment-targets in 2015 for adult IBD […]

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Population-based Screening for Hereditary Colorectal Cancer Variants in Japan.

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Colorectal cancer (CRC) is one of the most common cancers in the world. A small proportion of CRCs can be attributed to recognizable hereditary germline variants of known CRC susceptibility […]

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Refining the Baveno VI elastography criteria for the definition of compensated advanced chronic liver disease.

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The Baveno VI consensus proposed a dual liver stiffness (LS) by transient elastography threshold of <10 and >15 kPa for excluding and diagnosing compensated advanced chronic liver disease (cACLD), in […]

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Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort.

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Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and […]

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Development and initial psychometric validation of a patient-reported outcome measure for Crohn’s perianal fistula: the Crohn’s Anal Fistula Quality of Life (CAF-QoL) scale.

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Crohn’s perianal fistulas are challenging for patients and clinicians. Many do not respond to available treatments and despite recommendations by a global consensus, there are currently no specific patient-derived quality […]

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Risk and time pattern of recurrences after local endoscopic resection of T1 colorectal cancer: a meta-analysis.

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Growing numbers of T1 CRC patients are being treated with local endoscopic resection only and as a result, the need for optimization of surveillance strategies for these patients also increases. […]

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Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis.

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In 2016, of the estimated 257 million people living with chronic hepatitis B virus (HBV) infection worldwide, only a small proportion was diagnosed and treated. The insufficiency of information on […]

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Effectiveness of capsule endoscopy and double-balloon enteroscopy in suspected complicated celiac disease.

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Complicated celiac disease (CCD) is a rare but severe condition with a poor prognosis. Guidelines recommend use of capsule endoscopy (CE) to explore the small bowel (SB), followed by a […]

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The Latin American Association for the Study of the Liver (ALEH) position statement on the redefinition of fatty liver disease.

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The Latin American Association for the Study of the Liver (Asociación Latinoamericana para el Estudio del Hígado; ALEH) represents liver professionals in Latin America with the mission of promoting liver […]

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Nomenclature and definition of metabolic-associated fatty liver disease: a consensus from the Middle East and north Africa.

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With the increasing prevalence of obesity and type 2 diabetes, fatty liver disease associated with metabolic dysfunction is a global health problem, especially because it is one of the earliest […]

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Efficacy and Safety of Ornithine Phenylacetate for Treating Overt Hepatic Encephalopathy in a Randomized Trial.

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Hepatic encephalopathy (HE) is associated with increased morbidity, mortality, and healthcare resource use. In this phase 2b study, we evaluated the efficacy and safety of ornithine phenylacetate (OP), an ammonia […]

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Guidelines on the management of ascites in cirrhosis.

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The British Society of Gastroenterology in collaboration with British Association for the Study of the Liver has prepared this document. The aim of this guideline is to review and summarise […]

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Redefining fatty liver disease: an international patient perspective.

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Despite its increased recognition as a major health threat, fatty liver disease associated with metabolic dysfunction remains largely underdiagnosed and undertreated. An international consensus panel has called for the disease […]

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Comparing costs and outcomes of treatments for irritable bowel syndrome with diarrhea: cost-benefit analysis.

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Irritable bowel syndrome (IBS) is one of the most expensive gastroenterological conditions and is an ideal target for developing a value-based care model. We assessed the comparative cost-benefit of treatments […]

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Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus.

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A global consensus meeting was held to review current evidence and knowledge gaps and propose collaborative studies on population-wide screening and eradication of Helicobacter pylori for prevention of gastric cancer […]

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Serrated Polyps and the Risk of Metachronous Colorectal Advanced Neoplasia: A Systematic Review and Meta-analysis.

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Surveillance recommendations for serrated polyps (SPs) are based on insufficient evidence. We aimed to evaluate the risk of metachronous advanced colorectal neoplasia (ACRN) associated with SPs.We searched all relevant studies […]

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TP53, a gene for colorectal cancer predisposition in the absence of Li-Fraumeni-associated phenotypes.

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Germline TP53 pathogenic (P) variants cause Li-Fraumeni syndrome (LFS), an aggressive multitumor-predisposing condition. Due to the implementation of multigene panel testing, TP53 variants have been detected in individuals without LFS […]

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Artificial Intelligence System to Determine Risk of T1 Colorectal Cancer Metastasis to Lymph Node.

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In accordance with guidelines, most patients with T1 colorectal cancers (CRC) undergo surgical resection with lymph node dissection, despite the low incidence (∼10%) of metastasis to lymph node. To reduce […]

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Predicting Outcomes in Pediatric Crohn’s Disease for Management Optimization: Systematic Review and Consensus Statements from PIBD-Ahead Program.

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A better understanding of prognostic factors within the heterogeneous spectrum of pediatric Crohn’s disease (CD) should improve patient management and reduce complications. We aimed to identify evidence-based predictors of outcomes […]

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Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements from PIBD-Ahead Program.

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A better understanding of prognostic factors in ulcerative colitis (UC) could improve patient management and reduce complications. We aimed to identify evidence-based predictors for outcomes in pediatric UC, which may […]

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Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline.

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This guideline will provide the practicing endocrinologist with an approach to assessment and treatment of dyslipidemia in patients with endocrine diseases, with the objective of prevention of cardiovascular events and […]

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AGA White Paper: Interventional Endoscopic Ultrasound – Current Status and Future Directions.

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The evolution of endoscopic ultrasound (EUS) from a diagnostic to a therapeutic procedure has resulted in a paradigm shift towards endoscopic management of disease states that have previously required percutaneous […]

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IMPACT OF PHYSICIANS’ AND PATIENTS’ COMPLIANCE ON OUTCOMES OF COLONOSCOPIC POLYPECTOMY WITH ANTI-THROMBOTIC THERAPY.

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Although there are international guidelines on the management of anti-thrombotic therapy in patients undergoing colonoscopic polypectomy, whether clinicians and patients follow these recommendations are largely unknown.We aimed to evaluate clinicians’ […]

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Provider attitudes toward risk-based hepatocellular carcinoma surveillance in patients with cirrhosis in the U.S.

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Hepatocellular carcinoma (HCC) surveillance rates are suboptimal in clinical practice. We aimed to elicit providers’ opinions on the following aspects of HCC surveillance: preferred strategies, barriers and facilitators, and the […]

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Adult liver transplantation: A UK clinical guideline – part 1: pre-operation.

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Liver transplantation is a highly successful treatment for all types of liver failure, some non-liver failure indications and liver cancer. Most referrals come from secondary care. This first part of […]

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