Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis.

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In 2016, of the estimated 257 million people living with chronic hepatitis B virus (HBV) infection worldwide, only a small proportion was diagnosed and treated. The insufficiency of information on […]

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Effectiveness of capsule endoscopy and double-balloon enteroscopy in suspected complicated celiac disease.

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Complicated celiac disease (CCD) is a rare but severe condition with a poor prognosis. Guidelines recommend use of capsule endoscopy (CE) to explore the small bowel (SB), followed by a […]

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The Latin American Association for the Study of the Liver (ALEH) position statement on the redefinition of fatty liver disease.

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The Latin American Association for the Study of the Liver (Asociación Latinoamericana para el Estudio del Hígado; ALEH) represents liver professionals in Latin America with the mission of promoting liver […]

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Nomenclature and definition of metabolic-associated fatty liver disease: a consensus from the Middle East and north Africa.

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With the increasing prevalence of obesity and type 2 diabetes, fatty liver disease associated with metabolic dysfunction is a global health problem, especially because it is one of the earliest […]

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Efficacy and Safety of Ornithine Phenylacetate for Treating Overt Hepatic Encephalopathy in a Randomized Trial.

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Hepatic encephalopathy (HE) is associated with increased morbidity, mortality, and healthcare resource use. In this phase 2b study, we evaluated the efficacy and safety of ornithine phenylacetate (OP), an ammonia […]

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Guidelines on the management of ascites in cirrhosis.

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The British Society of Gastroenterology in collaboration with British Association for the Study of the Liver has prepared this document. The aim of this guideline is to review and summarise […]

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Redefining fatty liver disease: an international patient perspective.

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Despite its increased recognition as a major health threat, fatty liver disease associated with metabolic dysfunction remains largely underdiagnosed and undertreated. An international consensus panel has called for the disease […]

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Comparing costs and outcomes of treatments for irritable bowel syndrome with diarrhea: cost-benefit analysis.

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Irritable bowel syndrome (IBS) is one of the most expensive gastroenterological conditions and is an ideal target for developing a value-based care model. We assessed the comparative cost-benefit of treatments […]

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Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus.

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A global consensus meeting was held to review current evidence and knowledge gaps and propose collaborative studies on population-wide screening and eradication of Helicobacter pylori for prevention of gastric cancer […]

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Serrated Polyps and the Risk of Metachronous Colorectal Advanced Neoplasia: A Systematic Review and Meta-analysis.

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Surveillance recommendations for serrated polyps (SPs) are based on insufficient evidence. We aimed to evaluate the risk of metachronous advanced colorectal neoplasia (ACRN) associated with SPs.We searched all relevant studies […]

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TP53, a gene for colorectal cancer predisposition in the absence of Li-Fraumeni-associated phenotypes.

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Germline TP53 pathogenic (P) variants cause Li-Fraumeni syndrome (LFS), an aggressive multitumor-predisposing condition. Due to the implementation of multigene panel testing, TP53 variants have been detected in individuals without LFS […]

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Artificial Intelligence System to Determine Risk of T1 Colorectal Cancer Metastasis to Lymph Node.

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In accordance with guidelines, most patients with T1 colorectal cancers (CRC) undergo surgical resection with lymph node dissection, despite the low incidence (∼10%) of metastasis to lymph node. To reduce […]

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Predicting Outcomes in Pediatric Crohn’s Disease for Management Optimization: Systematic Review and Consensus Statements from PIBD-Ahead Program.

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A better understanding of prognostic factors within the heterogeneous spectrum of pediatric Crohn’s disease (CD) should improve patient management and reduce complications. We aimed to identify evidence-based predictors of outcomes […]

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Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements from PIBD-Ahead Program.

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A better understanding of prognostic factors in ulcerative colitis (UC) could improve patient management and reduce complications. We aimed to identify evidence-based predictors for outcomes in pediatric UC, which may […]

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Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline.

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This guideline will provide the practicing endocrinologist with an approach to assessment and treatment of dyslipidemia in patients with endocrine diseases, with the objective of prevention of cardiovascular events and […]

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AGA White Paper: Interventional Endoscopic Ultrasound – Current Status and Future Directions.

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The evolution of endoscopic ultrasound (EUS) from a diagnostic to a therapeutic procedure has resulted in a paradigm shift towards endoscopic management of disease states that have previously required percutaneous […]

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IMPACT OF PHYSICIANS’ AND PATIENTS’ COMPLIANCE ON OUTCOMES OF COLONOSCOPIC POLYPECTOMY WITH ANTI-THROMBOTIC THERAPY.

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Although there are international guidelines on the management of anti-thrombotic therapy in patients undergoing colonoscopic polypectomy, whether clinicians and patients follow these recommendations are largely unknown.We aimed to evaluate clinicians’ […]

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Provider attitudes toward risk-based hepatocellular carcinoma surveillance in patients with cirrhosis in the U.S.

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Hepatocellular carcinoma (HCC) surveillance rates are suboptimal in clinical practice. We aimed to elicit providers’ opinions on the following aspects of HCC surveillance: preferred strategies, barriers and facilitators, and the […]

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Adult liver transplantation: A UK clinical guideline – part 1: pre-operation.

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Liver transplantation is a highly successful treatment for all types of liver failure, some non-liver failure indications and liver cancer. Most referrals come from secondary care. This first part of […]

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Factors Associated With Adequate Lamina Propria Sampling and Presence of Lamina Propria Fibrosis in Children with Eosinophilic Esophagitis.

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Esophageal biopsies in children with eosinophilic esophagitis (EoE) are often inadequate for assessment of lamina propria and lamina propria fibrosis (LPF). For children with EoE, little is known about the […]

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The importance of anal cancer screening and high-resolution anoscopy to gastroenterology practice.

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Although human papillomavirus (HPV)-related anal squamous cell cancer (ASCC) is rare, its incidence has been rising and in high-risk populations exceeds the incidence of cancers for which screening programs are […]

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Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-based Colorectal Cancer Screening Program.

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Some guidelines recommend starting colorectal cancer (CRC) screening before age 50 years for African Americans, but there are few data on screening uptake and yield in this population.We performed a […]

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Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning.

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Complex phenotypes captured on histological slides represent the biological processes at play in individual cancers, but the link to underlying molecular classification has not been clarified or systematised. In colorectal […]

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