Restarting Warfarin versus Direct Oral Anticoagulants after Major Gastrointestinal Bleeding and Associated Outcomes in Atrial Fibrillation: A Cohort Study.

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Limited data exists on management of anticoagulation following hospitalization for gastrointestinal bleeding (GIB) and risks of recurrent GIB and thromboembolism in patients prescribed warfarin versus direct oral anticoagulants (DOACs). The […]

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Effective Treatment of Acute Severe Ulcerative Colitis in Pregnancy Is Associated with Good Maternal and Fetal Outcomes.

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Data regarding the management and outcomes of acute severe ulcerative colitis (ASUC) in pregnant patients is sparse, consisting mainly of case reports.1-3 We report on the largest cohort of pregnant […]

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Pregnancy and Neonatal Outcomes after Fetal Exposure To Biologics and Thiopurines among Women with Inflammatory Bowel Disease.

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Pregnant women with inflammatory bowel disease (IBD) may require biologic or thiopurine therapy to control disease activity. Lack of safety data has led to therapy discontinuation during pregnancy with health […]

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Colorectal cancer screening with repeated fecal immunochemical test versus sigmoidoscopy: baseline results from a randomized trial.

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The comparative effectiveness of sigmoidoscopy and fecal immunochemical testing (FIT) for colorectal cancer (CRC) screening is unknown.Individuals aged 50-74 years living in South-East Norway were randomly invited between 2012 and […]

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Fusobacterium nucleatum adheres to Clostridioides difficile via the RadD adhesin to enhance biofilm formation in intestinal mucus.

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Although Clostridioides difficile infection (CDI) is known to involve the disruption of the gut microbiota, little is understood regarding how mucus-associated microbes interact with C. difficile. We hypothesized that select […]

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Esophageal Eosinophilia Common Among Relatives.

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Familial clustering of eosinophilic esophagitis (EoE) has been described, but biopsy-assessed prevalence of esophageal eosinophilia (EE) in first degree family members has never been reported. The aim was to determine […]

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Impact of 9-minute Withdrawal Time on the Adenoma Detection Rate: A Multicenter Randomized Controlled Trial.

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Although current quality indicators of colonoscopy recommend 6 minutes as the minimum standard for withdrawal time (WT), the impact of a WT longer than 6 minutes on neoplasia detection is […]

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Comparative Outcomes of Cap Assisted Endoscopic Resection and Endoscopic Submucosal Dissection in Dysplastic Barrett’s Esophagus.

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Endoscopic resection (ER) is an important component of the endoscopic treatment of Barrett’s Esophagus (BE) with dysplasia and intramucosal adenocarcinoma (IMC). ER can be performed by cap assisted endoscopic mucosal […]

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Targeting Nestin+ hepatic stellate cells ameliorates liver fibrosis by facilitating TβRI degradation.

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Liver fibrosis is a wound-healing response that arises from various aetiologies. The intermediate filament protein, Nestin, has been reported to participate in maintaining tissue homeostasis during wound healing responses. However, […]

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RNA m6A methyltransferase METTL3 facilitates colorectal cancer by activating m6A-GLUT1-mTORC1 axis and is a therapeutic target.

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RNA N6-methyladenosine (m6A) modification has recently emerged as a new regulatory mechanism in cancer progression. We aimed to explore the role of m6A regulatory enzyme METTL3 in colorectal cancer (CRC) […]

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Esophagitis in patients without gastroesophageal reflux disease or eosinophilic esophagitis: diagnostic considerations.

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A multitude of inflammatory diseases other than gastroesophageal reflux disease (GERD) and eosinophilic esophagitis can affect the esophagus. Despite the deceptively simple organization of squamous mucosa and its limited number […]

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MRE combined with FIB-4 (MEFIB) index in detection of candidates for pharmacological treatment of NASH-related fibrosis.

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Patients with non-alcoholic fatty liver disease (NAFLD) with ≥stage 2 fibrosis are at increased risk for liver-related mortality and are candidates for pharmacological therapies for treatment of NAFLD. The aim […]

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Multicentre randomised controlled trial on virtual chromoendoscopy in the detection of neoplasia during colitis surveillance high-definition colonoscopy (the VIRTUOSO trial).

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Longstanding colonic IBD increases the risk of developing colorectal cancer. The utility of chromoendoscopy with standard-definition white light technology has been established. However, the use of high-definition virtual chromoendoscopy (HDV) […]

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