Children with Multiple Endocrine Neoplasia type 2B: not tall and marfanoid, but short with normal body proportions.

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Multiple Endocrine Neoplasia 2B (MEN2B) is characterized by early-onset medullary thyroid carcinoma (MTC), pheochromocytoma and several non-endocrine manifestations. Unfortunately, MEN2B is often diagnosed late, after development of clinically significant MTC. […]

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Clinical implications of age and excellent response to therapy in patients with high-risk differentiated thyroid carcinoma.

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Patients with American Thyroid Association (ATA) high-risk differentiated thyroid carcinoma (DTC) have poor clinical outcomes. This study aimed to evaluate the clinical implications of age and response to therapy classification […]

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Fenofibrate Use Is Associated With Lower Mortality and Fewer Cardiovascular Events in Patients With Diabetes: Results of 10,114 Patients From the Korean National Health Insurance Service Cohort.

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We investigated the long-term clinical efficacy of fenofibrate use with regard to mortality and cardiovascular outcomes in patients with type 2 diabetes.We performed a population-based cohort study using data of […]

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Intensive Care Unit Admission, Mechanical Ventilation, and Mortality Among Patients With Type 1 Diabetes Hospitalized for COVID-19 in the U.S.

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To assess whether risk of severe outcomes among patients with type 1 diabetes mellitus (T1DM) hospitalized for coronavirus disease 2019 (COVID-19) differs from that of patients without diabetes or with […]

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Long-term response to cabergoline and multi-modal treatment in men with macroprolactinoma: does size really matter?

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To study the outcome of men with macroprolactinoma following cabergoline treatment based on tumour size.Retrospective cohort study.The study included 94 men, divided into 3 groups according to adenoma diameter: 10-19 mm […]

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Male Pituitary-Gonadal axis dysfunction in Post-acute COVID-19 Syndrome. Prevalence and associated factors: A Mediterranean Case Series.

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SARS-CoV-2 through ACE2 receptor could harm testes function. The objectives were to analyze the prevalence of low serum testosterone (LT) and impaired fertility potential (Leydig and Sertoli cells dysfunction, respectively) […]

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Predicting Malignancy with Pediatric Thyroid Nodules: Early Experience in Machine Learning for Clinical Decision Support.

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Papillary thyroid carcinoma is the most common endocrine malignancy. Since most nodules are benign, the challenge for the clinician is to identify those most likely to harbour malignancy while limiting […]

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Predictors of prolonged hypotension requiring vasopressor support after resection of pheochromocytoma and paraganglioma.

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Prolonged hypotension is a common complication after resection of pheochromocytoma (PCC) or paraganglioma (PGL). The objective of our study was to identify preoperative or intraoperative clinical factors that can predict […]

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The Use of Morning Urinary Gonadotropins and Sexual Hormones in the Management of Early Puberty in Chinese Girls.

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Although gonadotropin-releasing hormone stimulation test (GnRHST) is the gold standard in diagnosing central precocious puberty (CPP), it is invasive, expensive, and time-consuming, requiring multiple blood samples to measure gonadotropin levels.We […]

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Weight Loss by Low-Calorie Diet Versus Gastric Bypass Surgery in People With Diabetes Results in Divergent Brain Activation Patterns: A Functional MRI Study.

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Weight loss achieved with very-low-calorie diets (VLCDs) can produce remission of type 2 diabetes (T2D), but weight regain very often occurs with reintroduction of higher calorie intakes. In contrast, bariatric […]

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High-Throughput Molecular Analysis of Pseudohypoparathyroidism 1b Patients Reveals Novel Genetic and Epigenetic Defects.

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Patients with pseudohypoparathyroidism type 1b (PHP1b) show disordered imprinting of the maternal GNAS allele or paternal uniparental disomy (UPD). Genetic deletions in STX16 or in upstream exons of GNAS are […]

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Protective Role of DHEAS in Age-related Changes in Bone Mass and Fracture Risk: A Mendelian Randomization Study.

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Dehydroepiandrosterone sulfate (DHEAS) from the adrenal cortex substantially decreases with age, which may accelerate osteoporosis. However, the association of DHEAS with bone mineral density (BMD) and fracture is inconclusive. We […]

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Academic performance in adolescents born to mothers with gestational diabetes – a national Danish cohort study.

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The prevalence of Gestational Diabetes Mellitus (GDM) is increasing, and intrauterine hyperglycemia is suspected to affect offspring cognitive function.We assessed academic performance by grade point average (GPA) in children aged […]

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Breast cancer risk factors and circulating anti-Müllerian hormone concentration in healthy premenopausal women.

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In a previous study we reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies.Assess whether risk factors for […]

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Do patients with atypical parathyroid adenoma need a close follow-up?

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Atypical parathyroid adenomas (APAs) are neoplasms with uncertain malignant potential but lack unequivocal histological signs of malignancy.To retrospectively evaluate the clinical and biochemical profiles of patients with APA, the outcome […]

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Efficacy and safety of intravenous pamidronate for parathyroid hormone-dependent hypercalcemia in hospitalized patients.

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Bisphosphonates are effective for hypercalcemia of malignancy (HOM). Efficacy and safety data for bisphosphonates in parathyroid hormone-related hypercalcemia (PTHRH) are rare, including pamidronate, which is not indicated for this condition.To […]

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Erectile function in men with type 2 diabetes treated with dulaglutide: an exploratory analysis of the REWIND placebo-controlled randomised trial.

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Diabetes is a major risk factor for erectile dysfunction, however, the effect of GLP-1 receptor agonists on erectile dysfunction is unknown. We aimed to assess the incidence, prevalence, and progression […]

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Hyperandrogenemia in Early Adulthood Is an Independent Risk Factor for Abnormal Glucose Metabolism in Middle Age.

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The role of androgen excess as a contributing factor to abnormal glucose metabolism (AGM) and insulin resistance in women remains controversial.To investigate whether hyperandrogenemia (HA) estimated by serum testosterone (T) […]

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Novel anaplastic thyroid cancer PDXs and cell lines: Expanding preclinical models of genetic diversity.

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Anaplastic thyroid cancer (ATC) is a rare, aggressive, and deadly disease. Robust pre-clinical thyroid cancer models are needed to adequately develop and study novel therapeutic agents. Patient-derived xenograft (PDX) models […]

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Tildacerfont in Adults with Classic Congenital Adrenal Hyperplasia: Results from Two Phase 2 Studies.

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Congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD) is typically treated with lifelong supraphysiologic doses of glucocorticoids (GCs). Tildacerfont, a corticotropin-releasing factor type-1 receptor antagonist, may reduce excess androgen production, […]

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Genetic support of a causal relationship between iron status and type 2 diabetes: a Mendelian randomization study.

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Iron overload is a known risk factor for type 2 diabetes (T2D); however, both iron overload and iron deficiency have been associated with metabolic disorders in observational studies.Using Mendelian randomization […]

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Identification Of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases By Deep Sequencing Of Linked Loci.

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Genetic risk factors play a major role in the pathoetiology of autoimmune thyroid diseases (AITD). So far, only common risk variants have been identified in AITD susceptibility genes. Recently, rare […]

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An open-label phase Ⅰ/Ⅱ a clinical trial of 11β-HSD1 inhibitor for Cushing’s syndrome and autonomous cortisol secretion.

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11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors demonstrate anti-metabolic and anti-sarcopenic effects in Cushing’s syndrome (CS) and autonomous cortisol secretion (ACS) patients.To confirm the efficacy and safety of S-707106 (11β-HSD1 inhibitor) […]

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Combination of mitotane and locoregional treatments in low-volume metastatic adrenocortical carcinoma.

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European and French guidelines for ENSAT stage IV low tumor burden or indolent adrenocortical carcinoma (ACC) recommend combination of mitotane and locoregional treatments (LRT) in first-line. Nevertheless, the benefit of […]

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