Impact of peri-procedural subcutaneous parathyroid hormone on control of hypocalcemia in APS-1/APECED patients undergoing invasive procedures.

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The monogenic disorder autoimmune polyendocrine syndrome type 1 (APS-1) or autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) manifests frequently with hypoparathyroidism, which requires treatment with oral supplementation with calcium and active vitamin D […]

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Temporal trends in craniopharyngioma management and long-term endocrine outcomes: a multicentre cross-sectional study.

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The optimal management of craniopharyngiomas remains controversial.To examine temporal trends in the management of craniopharyngioma with a focus on endocrine outcomes.This was a cross-sectional, multicentre study. Patients treated between 1951 […]

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Effect of Long-Term Glucocorticoid Therapy on Cardiac Functions in Children with Congenital Adrenal Hyperplasia.

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Glucocorticoids play an important role in cardiac physiology. Chronic exposure and higher doses may cause adverse effects on the myocardium, especially in young patients receiving long term therapy.Assess cardiac function […]

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Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial.

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Although metformin is increasingly being used in women with type 2 diabetes during pregnancy, little data exist on the benefits and harms of metformin use on pregnancy outcomes in these […]

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A Decade of Disparities in Diabetes Technology Use and HbA1c in Pediatric Type 1 Diabetes: A Transatlantic Comparison.

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As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A1c (HbA1c). We hypothesized that an increasing gap in diabetes technology use by socioeconomic […]

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Evaluating the low-dose ACTH stimulation test (LDST) in neonates: Ideal times for cortisol measurement.

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Low-dose adrenocorticotropic hormone stimulation testing (LDST) can be used to diagnose central adrenal insufficiency. However, uncertainty remains over optimal times to draw serum cortisol levels.To determine optimal times to draw […]

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Association of Prodromal Type 1 Diabetes With School Absenteeism of Danish Schoolchildren: A Population-Based Case-Control Study of 1,338 Newly Diagnosed Children.

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To investigate school absenteeism before the clinical diagnosis of type 1 diabetes in children who develop the disease.This population-based, retrospective case-control study involved all Danish children who developed type 1 […]

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Clinical characteristics and long-term follow-up of patients with diabetes due to PTF1A enhancer mutations.

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Biallelic mutations in the PTF1A enhancer are the commonest cause of isolated pancreatic agenesis. These patients do not have severe neurological features associated with loss-of-function PTF1A mutations. Their clinical phenotype […]

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The clinical consequences of heterogeneity within and between different diabetes types.

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Advances in molecular methods and the ability to share large population-based datasets are uncovering heterogeneity within diabetes types, and some commonalities between types. Within type 1 diabetes, endotypes have been […]

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Clinical characteristics and long-term follow-up of patients with diabetes due to PTF1A enhancer mutations.

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Biallelic mutations in the PTF1A enhancer are the commonest cause of isolated pancreatic agenesis. These patients do not have severe neurological features associated with loss-of-function PTF1A mutations. Their clinical phenotype […]

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The clinical consequences of heterogeneity within and between different diabetes types.

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Advances in molecular methods and the ability to share large population-based datasets are uncovering heterogeneity within diabetes types, and some commonalities between types. Within type 1 diabetes, endotypes have been […]

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A Prospective Study Of Children 0-7 Years With Cah And Adrenal Insufficiency Treated With Hydrocortisone Granules.

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Children with congenital adrenal hyperplasia (CAH) and adrenal insufficiency (AI) require daily hydrocortisone replacement with accurate dosing.Prospective study of efficacy and safety of hydrocortisone granules in children with AI and […]

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Gut microbiota profile and selected plasma metabolites in type 1 diabetes without and with stratification by albuminuria.

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Abnormal gut microbiota and blood metabolome profiles have been reported both in children and adults with uncomplicated type 1 diabetes as well as in adults with type 1 diabetes and […]

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Dynamics of Islet Autoantibodies During Prospective Follow-Up from Birth up to 15 Years of Age.

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We set out to characterize the dynamics of islet autoantibodies over the first 15 years of life in children carrying genetic susceptibility to type 1 diabetes (T1D). We assessed also […]

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Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes.

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Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise derivatives of bacterial riboflavin metabolites presented by MHC-Ib-related protein 1 (MR1) molecules and are important effector cells for mucosal […]

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Childhood BMI and Fasting Glucose and Insulin Predict Adult Type 2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium.

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To examine childhood BMI, fasting glucose, and insulin in relation to incident adult type 2 diabetes mellitus (T2DM).We used data from The International Childhood Cardiovascular Cohort Consortium. Data included childhood […]

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Body composition and bone mineral density in craniopharyngioma patients: a longitudinal study over 10 years.

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Patients with craniopharyngioma suffer from obesity and impaired bone health. Little is known about longitudinal changes in body composition and bone mineral density (BMD).To describe body composition and BMD (change).Retrospective […]

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Central hypothyroidism improves with age in very young children with Prader-Willi syndrome.

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Abnormalities in the hypothalamic-pituitary-thyroid (HPT) axis have been implicated in Prader-Willi syndrome (PWS); however, limited information is currently available on age-dependent alterations in the HPT axis. We herein investigated age-dependent […]

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Premature adrenarche in girls is characterized by enhanced 17,20-lyase and 17β-hydroxysteroid dehydrogenase activities.

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Girls with premature adrenarche (PA) may have a higher risk to develop polycystic ovary syndrome (PCOS) and metabolic syndrome. The biological purpose of adrenarche is unknown and the role of […]

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Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes.

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Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + […]

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Sex Hormone Relations to Histologic Severity of Pediatric Nonalcoholic Fatty Liver Disease.

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Sex hormones have been linked with presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults, but it is unknown if they impact severity of pediatric NAFLD.To examine associations […]

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Non-alcoholic fatty liver disease and estimated insulin resistance in obese youth: a Mendelian randomization analysis.

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Non-alcoholic fatty liver disease (NAFLD) is associated with insulin resistance (IR) and predicts type 2 diabetes. Currently, it is uncertain whether NAFLD may directly cause IR or vice versa.To test […]

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Impact of preconception treatment initiation for hypothyroidism on neurocognitive function in children.

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Levothyroxine treatment for hypothyroidism in early pregnancy has inconsistent outcomes.This study evaluated children’s cognitive function to ascertain the impact of preconception maternal hypothyroidism treatment on fetal neurodevelopment.Prospective cohort study.A single-center […]

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Copeptin kinetics and its relationship to osmolality during rehydration for diabetic ketoacidosis in children.

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Copeptin is a surrogate marker for arginine vasopressin (AVP) release in response to hyperosmolal stimuli such as diabetic ketoacidosis (DKA).Characterize kinetics of copeptin and osmolality, and their dynamic relationship during […]

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Reproduction Function in Male Patients with Bardet Biedl Syndrome.

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Bardet-Biedl syndrome (BBS) is a ciliopathy with a wide spectrum of symptoms due to primary cilia dysfunction including genitourinary developmental anomalies as well as impaired reproduction particularly in males. Primary […]

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The clinicopathological results of thyroid cancer with BRAFV600E mutation in the young population of Fukushima.

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Thyroid ultrasound screening for children aged 0-18 years was performed in Fukushima following the accident at the Fukushima Daiichi Nuclear Power Plant. As a result, many thyroid cancer cases were […]

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Gestational diabetes: opportunities for improving maternal and child health.

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Gestational diabetes, the most common medical disorder in pregnancy, is defined as glucose intolerance resulting in hyperglycaemia that begins or is first diagnosed in pregnancy. Gestational diabetes is associated with […]

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A Prospective Longitudinal Assessment of Linear Growth and Adult Height in Female Adolescents with Anorexia Nervosa.

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Growth retardation is an established complication of anorexia nervosa (AN), however findings concerning adult height of AN patients are inconsistent.To assess linear growth and adult height in female adolescents with […]

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NKX2-2 mutation causes congenital diabetes and infantile obesity with paradoxical glucose induced ghrelin secretion.

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NKX2-2 is a crucial transcription factor which enables specific beta-cell gene expression. Nkx2-2(-/-) mice manifest with severe neonatal diabetes and changes in beta cell progenitor fate into ghrelin producing cells. […]

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