Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height.To develop a polygenic risk score for adult height and evaluate its clinical utility.A […]» Read more
Central congenital hypothyroidism (CH) requires lifelong medical treatment. The majority of children with central CH have multiple pituitary hormone deficiencies (MPHD), but in some cases central CH is isolated. Most […]» Read more
Total thyroidectomy is recommended for children with papillary thyroid carcinoma, partly because of a high prevalence of bilateral disease. Identifying characteristics that predict bilateral disease might identify candidates for more […]» Read more
Radioactive Iodine Treatment for Children and Young Adults with Thyroid Cancer in South Korea: A Population-Based Study.
This study investigated radioactive iodine treatment (RAIT) patterns and the secondary cancer incidence among child and young adult patients receiving RAIT after thyroidectomy for thyroid cancer.This population-based cohort study used […]» Read more
Few and conflicting reports have characterized the genetics of paediatric pheochromocytomas and paragangliomas (PPGL). This study aimed to investigate the clinical and genetic features of Brazilian children with PPGL.This study […]» Read more
Congenital hypopituitarism (CH) can present in isolation or with other birth defects. Mutations in multiple genes can cause CH, and the use of a genetic screening panel could establish the […]» Read more
Two-year treatment with metformin during puberty does not preserve β-cell function in youth with obesity.
Youth-onset type 2 diabetes is a disease of pubertal onset, associated with additional burden of pubertal insulin resistance on the β-cell.Evaluate the impact of metformin treatment during puberty, a critical […]» Read more
Parabens are used as preservatives in consumer products but are suspected of having endocrine-disrupting properties. A recent study reported an association between in utero exposure to butyl paraben and overweight […]» Read more
Gestational diabetes mellitus is common and is associated with an increased risk of adverse maternal and perinatal outcomes. Although experts recommend universal screening for gestational diabetes, consensus is lacking about […]» Read more
Recombinant Human Thyroid-Stimulating Hormone Versus Thyroid Hormone Withdrawal Preparation for Radioiodine Ablation in Differentiated Thyroid Cancer in Children, Adolescents, and Young Adults.
Recombinant human TSH (rhTSH) is commonly used to prepare patients for postoperative radioiodine (I-131) ablation after surgery for differentiated thyroid cancer (DTC). In adults, rhTSH is associated with equivalent oncologic […]» Read more
Glycemic Outcome Associated With Insulin Pump and Glucose Sensor Use in Children and Adolescents With Type 1 Diabetes. Data From the International Pediatric Registry SWEET.
Insulin delivery methods, glucose-monitoring modalities, and related outcomes were examined in a large, international, diverse cohort of children and adolescents with type 1 diabetes from the Better Control in Pediatric […]» Read more
Cushing syndrome in a pediatric patient with a KCNJ5 variant and successful treatment with low dose ketoconazole.
Pathogenic variants in KCNJ5, encoding the GIRK4 (Kir3.4) potassium channel, have been implicated in the pahogenesis of familial hyperaldosteronism (FH) type-III (FH-III) and sporadic primary hyperaldosteronism (PA). In addition to […]» Read more
Newborn Adiposity and Cord Blood C-Peptide as Mediators of the Maternal Metabolic Environment and Childhood Adiposity.
Excessive childhood adiposity is a risk factor for adverse metabolic health. The objective was to investigate associations of newborn body composition and cord C-peptide with childhood anthropometrics and explore whether […]» Read more
Fat mass accretion from birth to 5 years and metabolic homeostasis in childhood: The Healthy Start Study.
It is unclear how fat mass accretion in early life is related to glucose-insulin homeostasis.Examine associations of fat and fat-free mass accretion from birth to early childhood with glucose-insulin homeostasis […]» Read more
A high proportion of novel ACAN mutations and their prevalence in a large cohort of Chinese short stature children.
Aggrecan, encoded by ACAN gene, is the main proteoglycan component in the extracellular cartilage matrix. Heterozygous mutations in ACAN have been reported to cause idiopathic short stature. However, the prevalence […]» Read more
The association of passive smoking and dyslipidemia among adolescence in Japan: Results from A-CHILD Study.
Passive smoking in childhood has been reported to be associated with dyslipidemia in Western countries. However, this association in Asian countries remains unclear. Further, no study has investigated the sex […]» Read more
Long-term safety of growth hormone treatment in childhood: Two large observational studies NordiNet ® IOS and ANSWER.
GH treatment has a generally good safety profile; however, concerns of increased mortality risk in adulthood have been raised.Assessing the long-term safety of GH treatment in clinical practice.Two multicenter longitudinal […]» Read more
Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children.
Multisystem inflammatory syndrome in children (MIS-C) is the most severe pediatric disease associated with severe acute respiratory syndrome coronavirus 2 infection, potentially life-threatening, but the optimal therapeutic strategy remains unknown.To […]» Read more
Skeletal Disproportion in Girls with Turner Syndrome and Longitudinal Change with Growth Promoting Therapy.
Short stature in Turner Syndrome (TS) may be accompanied by skeletal disproportion. This retrospective study investigates growth and disproportion from early childhood to adult height.Data were collected from 59 girls […]» Read more
Serum Galectin-3 and Subsequent Risk of Coronary Heart Disease in Subjects With Childhood-Onset Type 1 Diabetes: A Cohort Study.
To study whether serum galectin-3 and other biomarkers of inflammation predict coronary heart disease (CHD) in subjects with long-standing childhood-onset type 1 diabetes.A population-based nationwide cohort of 299 subjects with […]» Read more
First-appearing islet autoantibodies for type 1 diabetes in young children: maternal life events during pregnancy and the child’s genetic risk.
Psychological stress has long been considered a possible trigger of type 1 diabetes, although prospective studies examining the link between psychological stress or life events during pregnancy and the child’s […]» Read more
Long-term efficacy and safety of gonadotropin-releasing hormone analog treatment in children with idiopathic central precocious puberty: a systematic review and meta-analysis.
To investigate the long-term efficacy and safety of gonadotropin-releasing hormone analog (GnRHa) treatment in children with idiopathic central precocious puberty (CPP) METHOD: The protocol was registered with International Prospective Register […]» Read more
Congenital Glucagon-like peptide-1 deficiency in the pathogenesis of protracted diarrhea in Mitchell Riley syndrome.
Mitchell Riley syndrome (MRS) due to RFX6 gene mutations is characterized by neonatal diabetes and protracted diarrhea. RFX6 gene encodes a transcription factor involved in enteroendocrine cell differentiation required for […]» Read more
Distant metastases from childhood differentiated thyroid carcinoma: clinical course and mutational landscape.
Distant metastases (DM) from childhood differentiated thyroid carcinoma (DTC) are uncommon and published studies are limited.To describe the outcomes of patients with DM from childhood DTC and to evaluate the […]» Read more
Virilization is the medical term for describing a female who develops characteristics associated with male hormones (androgens) at any age, or when a newborn girl shows signs of prenatal male […]» Read more
Multiple Endocrine Tumors Associated with Germline MAX Mutations: Multiple Endocrine Neoplasia Type 5?
Pathogenic germline MAX variants are associated with pheochromocytoma and paraganglioma (PPGL), pituitary neuroendocrine tumors and, possibly, other endocrine and non-endocrine tumors.To report two families with germline MAX variants, pheochromocytomas (PC) […]» Read more
To further evaluate the safety and efficacy of the Control-IQ closed-loop control (CLC) system in children with type 1 diabetes.After a 16-week randomized clinical trial (RCT) comparing CLC with sensor-augmented […]» Read more
Both hyperthyroidism and hypothyroidism can have adverse effects in pregnancy. The most common causes of thyrotoxicosis in pregnancy are gestational transient thyrotoxicosis and Graves’ disease. It is important to distinguish […]» Read more
The Effects of Vitamin D Supplementation During Infancy on Growth During the First Two Years of Life.
The relationship between maternal and infant vitamin D and early childhood growth remains inadequately understood.To investigate how maternal and child 25-hydroxyvitamin D [25(OH)D] and vitamin D supplementation impact growth during […]» Read more
Thyroid ultrasound screening is recommended in children with PTEN hamartoma tumor syndrome (PHTS) due to increased risk of thyroid neoplasia, but the natural history of thyroid disease in children with […]» Read more