Preoperative topical estrogen treatment versus placebo in 244 children with midshaft and posterior hypospadias.

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Urethral fistula and dehiscence are common after hypospadias surgery. Preoperative androgens have been considered to reduce these complications although not evidence-based. Dermatologists have reported the benefits of topical Estrogens on […]

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Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents.

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The aim of this work was to evaluate geographical variability and trends in the prevalence of diabetic ketoacidosis (DKA), between 2006 and 2016, at the diagnosis of childhood-onset type 1 […]

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Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study.

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To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.Asymptomatic patients (8-45 years) were […]

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Maternal glycaemia during pregnancy and child carotid intima media thickness, pulse wave velocity and augmentation index.

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in women without diabetes, little is known about the consequences of hyperglycaemia during pregnancy for the offspring cardiovascular structure and function.To investigate the association of maternal glycaemia during pregnancy with […]

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Causal association of haptoglobin with obesity in Mexican children: a Mendelian randomization study.

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Little is known about the association between haptoglobin level and cardio-metabolic traits. A previous genome-wide association study identified rs2000999 in the HP gene as the stronger genetic contributor to serum […]

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Contributions of Prenatal Exposures and Child Lifestyle to Insulin Sensitivity.

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Determine how prenatal exposures to maternal obesity and/or gestational diabetes mellitus (GDM) and childhood lifestyle factors independently contribute to child insulin sensitivity.Ninety children aged 7-11 years (56% girls, 60% exposed […]

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The effect of patient-managed stress dosing on electrolytes and blood pressure in acute illness in children with adrenal insufficiency.

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Adrenal crises (AC) are acute episodes of adrenal insufficiency (AI). Manifestations include hypotension and electrolyte disturbances. Glucocorticoid stress dosing (SD) can prevent AC progression but its effect on physiological parameters […]

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The Joint Associations of Maternal BMI and Glycemia with Childhood Adiposity.

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An obesogenic perinatal environment contributes to adverse offspring metabolic health. Previous studies have been limited by lack of direct adiposity measurements and failure to account for potential confounders.Examine the joint […]

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2017 American Academy of Pediatrics Clinical Practice Guideline: Impact on Prevalence of Arterial Hypertension in Children and Adolescents With Type 1 Diabetes.

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In 2017, the American Academy of Pediatrics introduced a new guideline (2017 Clinical Practice Guideline of the American Academy of Pediatrics [AAP 2017]) to diagnose arterial hypertension (HTN) in children […]

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Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes.

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We investigated the association between changes in weight status from childhood through adulthood and subsequent type 2 diabetes risks and whether educational attainment, smoking, and leisure time physical activity (LTPA) […]

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Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis.

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The effect of early life antibiotic treatment on the risk of type 1 diabetes is debated. This study assessed this question, applying a register-based design in children up to age […]

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Serum Anti-Müllerian Hormone In The Prediction Of Response To hCG Stimulation In Children With DSD.

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The relationship between serum anti-Müllerian hormone (AMH) and the testosterone response to hCG stimulation test is unclear.Children who had hCG stimulation tests in one tertiary centre between 2001-2018 were included […]

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Cognitive function in children with idiopathic subclinical hypothyroidism: effects of two years of levothyroxine therapy.

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Long-term consequences of mild subclinical hypothyroidism (SH) in children are still unclear and the need for levothyroxine (L-T4) supplementation remains controversial. We designed a two-year, case-control prospective study on a […]

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The impact of obesity on insulin sensitivity and secretion during pubertal progression: a longitudinal study.

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Physiologic changes in glucose metabolism are well-described to occur during puberty. However, there are important gaps in understanding the interaction between obesity and the normal physiologic changes during puberty and […]

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Distribution of tri-ponderal mass index and its relation to body mass index in children and adolescents aged 10-20 years.

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Body mass index percentiles are widely used to determine overweight and obesity status in children and adolescents. Their limitations in clinical settings can be addressed.Reference ranges for the tri-ponderal mass […]

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NPR2 variants are frequent among children with familiar short stature and respond well to growth hormone therapy.

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The C-type natriuretic peptide receptor encoded by the NPR2 gene is a paracrine regulator of the growth plate, heterozygous NPR2 variants cause short stature with possible presence of different signs […]

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Racial Ethnic Disparities in Youth With Type 1 Diabetes Participating in Diabetes Summer Camps.

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Diabetes camps are beneficial for campers and include benefits such as increases in diabetes knowledge, glycemic control, and psychological functioning. Racial/ethnic minority youth are likely to have poorer disease management […]

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An activating variant in CTNNB1 is associated with a sclerosing bone dysplasia and adrenocortical neoplasia.

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The WNT/β-catenin pathway is central to the pathogenesis of various human diseases including those affecting bone development and tumour progression.To evaluate the role of a gain-of-function variant in CTNNB1 in […]

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Revisiting classical 3β-hydroxysteroid dehydrogenase 2 deficiency: lessons from 31 pediatric cases.

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The clinical effects of classical 3β-hydroxysteroid dehydrogenase 2 (3βHSD2) deficiency are insufficiently defined due to a limited number of published cases.To evaluate an integrated steroid metabolome and the short and […]

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Cognitive function of children and adolescents with congenital adrenal hyperplasia: importance of early diagnosis.

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Patients with classic CAH are treated postnatally with life-long glucocorticoid (GC) replacement therapy. Previous results on general cognitive ability in individuals with CAH have been conflicting.To evaluate long-term cognitive effects […]

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Once-weekly somapacitan versus daily GH in children with GH deficiency: Results from a randomized phase 2 trial.

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Daily GH injections can be burdensome for patients and carers. Somapacitan is a long-acting, reversible albumin-binding GH derivative in development for once-weekly administration in patients with GHD.Evaluate efficacy, safety and […]

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Genetic Susceptibility Determines β-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76).

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Previous studies suggested that childhood prediabetes might develop prior to obesity and be associated with relative insulin deficiency. We proposed that the insulin-deficient phenotype is genetically determined and tested this […]

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Cord blood metabolic markers are strong mediators of the effect of maternal adiposity on fetal growth in pregnancies across the glucose tolerance spectrum: the PANDORA study.

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We aimed to assess associations between cord blood metabolic markers and fetal overgrowth, and whether cord markers mediated the impact of maternal adiposity on neonatal anthropometric outcomes among children born […]

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