Multicenter Trial of a Tubeless, On-Body Automated Insulin Delivery System With Customizable Glycemic Targets in Pediatric and Adult Participants With Type 1 Diabetes.

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Advances in diabetes technology have transformed the treatment paradigm for type 1 diabetes, yet the burden of disease is significant. We report on a pivotal safety study of the first […]

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Prediction of type 1 diabetes at birth: cord blood metabolites versus genetic risk score in the MoBa cohort.

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Genetic markers are established as predictive of type 1 diabetes, but unknown early life environment is believed to be involved. Umbilical cord blood may reflect perinatal metabolism and exposures. We […]

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Maternal Mid-pregnancy Leptin and Adiponectin Levels as Predictors of Autism Spectrum Disorder: A Prenatal Cohort Study.

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Autism spectrum disorders (ASD) are a group of conditions characterized by impaired social function and repetitive behaviors. Their etiology is largely unknown.To examine the associations of maternal 2 nd trimester […]

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Society for Endocrinology UK Guidance On The Initial Evaluation Of A Suspected Difference or Disorder Of Sex Development (DSD) (Revised 2021).

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It is paramount that any child or adolescent with a suspected difference or disorder of sex development (DSD) is assessed by an experienced clinician with adequate knowledge about the range […]

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Reproductive hormone concentrations and associated anatomical responses: does soy formula affect minipuberty in boys?

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Soy formula feeding is common in infancy and is a source of high exposure to phytoestrogens, documented to influence vaginal cytology in female infants. Its influence on minipuberty in males […]

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Prevalence of thyroid dysfunction in postpartum women with suboptimal iodine and selenium and adequate iron status.

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Postpartum women experience thyroid dysfunction at twice the prevalence of the general population. Adequate biosynthesis of thyroid hormones depends on three trace elements: iodine, selenium and iron. This study aimed […]

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Additional Insulin is Required in Both the Early and Late Postprandial Periods for Meals High in Protein and Fat: A Randomised Trial.

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The pattern and quantity of insulin required for high protein high fat (HPHF) meals is not well understood.This study aimed to determine the amount and delivery pattern of insulin required […]

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Randomised controlled trial evaluating the use of Zoledronic acid in Duchenne Muscular Dystrophy.

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Patients with glucocorticoid dependent Duchenne Muscular Dystrophy (DMD) have increased fracture risk and reduced bone mineral density (BMD), often precipitating mobility loss.To investigate use of Zoledronic acid (ZA) in DMD […]

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Acute hyperglycaemia does not have a consistent adverse effect on exercise performance in recreationally active young people with type 1 diabetes: a randomised crossover in-clinic study.

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In individuals with type 1 diabetes, chronic hyperglycaemia impairs aerobic fitness. However, the effect of acute marked hyperglycaemia on aerobic fitness is unclear, and the impact of insulin level has […]

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National Trends in Pediatric Admissions for Diabetic Ketoacidosis, 2006-2016.

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Diabetic ketoacidosis (DKA) rates in the US are rising. Prior studies suggest higher rates in younger populations, but no studies have evaluated national trends in pediatric populations and differences by […]

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A community-based, multi-level, multi-setting, multi-component intervention to reduce weight gain among low socioeconomic status Latinx children with overweight or obesity: The Stanford GOALS randomised controlled trial.

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There are few long-term studies of interventions to reduce in low socioeconomic status children with overweight or obesity. The Stanford GOALS trial evaluated a 3-year, community-based, multi-level, multi-setting, multi-component (MMM) […]

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Free thyroxine in early pregnancy is an independent negative predictor of 3rd trimester HbA1c. Odense Child Cohort.

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Lower thyroid function outside pregnancy is associated with increased risk of type 2 diabetes mellitus. The relationship between thyroid function in early pregnancy and glucose status in 3rd trimester has […]

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Aversion to Off-Label Prescribing in Clinical Pediatric Weight Management: The Quintessential Double Standard.

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Pediatric obesity is now recognized as a chronic disease; yet few treatment options exist besides lifestyle modification therapy and bariatric surgery. We describe the limited availability of FDA-approved anti-obesity medications […]

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Thyroid nodules in childhood-onset Hashimoto’s thyroiditis: Frequency, risk factors, follow-up course, and genetic alterations of thyroid cancer.

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We evaluated the frequency, risk factors, and the follow-up outcomes of thyroid nodules, and genetic alterations in thyroid cancer, in youth with childhood-onset Hashimoto thyroiditis (HT) residing in an iodine-sufficient […]

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Eligibility for growth hormone therapy in children born small for gestational age is substantially lower than expected.

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Growth hormone therapy is indicated for children who are both born “small-for-gestational-age” (SGA) and do not achieve adequate catch-up growth (ACUG).To evaluate the actual incidence of infants born SGA and […]

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Sequencing cell-free fetal DNA in pregnant women with GCK-MODY: a proof-of-concept study.

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Persons with monogenic diabetes due to inactivating glucokinase (GCK) variants typically do not require treatment, except potentially during pregnancy. In pregnancy, fetal GCK genotype determines whether treatment is indicated, but […]

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The Rapid Transition to Telemedicine and Its Effect on Access to Care for Patients With Type 1 Diabetes During the COVID-19 Pandemic.

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We compared the uptake of telemedicine for diabetes care across multiple demographic groups during the coronavirus disease 2019 pandemic to understand the impact of telemedicine adoption on access to care.The […]

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Associations Between Exposure to Gestational Diabetes Mellitus In Utero and Daily Energy Intake, Brain Responses to Food Cues, and Adiposity in Children.

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Children exposed to gestational diabetes mellitus (GDM) or maternal obesity in utero have an increased propensity to develop obesity. Little is known about the mechanisms underlying this phenomenon. We aimed […]

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Clinical and hormonal profiles correlate with molecular characteristics in patients with 11β-hydroxylase deficiency.

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Given the rarity of 11β-hydroxylase deficiency (11βOHD), there is a paucity of data about the differences in clinical and biochemical characteristics of classic (C-11βOHD) and non-classic 11βOHD (NC-11βOHD).To characterize a […]

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A polygenic risk score to predict future adult short stature amongst children.

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Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height.To develop a polygenic risk score for adult height and evaluate its clinical utility.A […]

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Health-related quality of life in patients with early-detected central congenital hypothyroidism.

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Central congenital hypothyroidism (CH) requires lifelong medical treatment. The majority of children with central CH have multiple pituitary hormone deficiencies (MPHD), but in some cases central CH is isolated. Most […]

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Predictors of Bilateral Disease in Pediatric Differentiated Thyroid Cancer.

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Total thyroidectomy is recommended for children with papillary thyroid carcinoma, partly because of a high prevalence of bilateral disease. Identifying characteristics that predict bilateral disease might identify candidates for more […]

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Radioactive Iodine Treatment for Children and Young Adults with Thyroid Cancer in South Korea: A Population-Based Study.

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This study investigated radioactive iodine treatment (RAIT) patterns and the secondary cancer incidence among child and young adult patients receiving RAIT after thyroidectomy for thyroid cancer.This population-based cohort study used […]

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Genetic and clinical aspects of paediatric pheochromocytomas and paragangliomas.

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Few and conflicting reports have characterized the genetics of paediatric pheochromocytomas and paragangliomas (PPGL). This study aimed to investigate the clinical and genetic features of Brazilian children with PPGL.This study […]

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Comprehensive identification of pathogenic gene variants in patients with neuroendocrine disorders.

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Congenital hypopituitarism (CH) can present in isolation or with other birth defects. Mutations in multiple genes can cause CH, and the use of a genetic screening panel could establish the […]

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Two-year treatment with metformin during puberty does not preserve β-cell function in youth with obesity.

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Youth-onset type 2 diabetes is a disease of pubertal onset, associated with additional burden of pubertal insulin resistance on the β-cell.Evaluate the impact of metformin treatment during puberty, a critical […]

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