Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study.

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Abstract: Both visceral and truncal fat have been associated with metabolic disturbances. We aimed to investigate the associations of several novel metabolic indices, combining anthropometric and lipid measures, and dual-energy […]

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Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial.

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Many patients with type 2 diabetes do not achieve sustained diabetes remission after metabolic (bariatric) surgery for the treatment of obesity. Liraglutide, a glucagon-like peptide-1 analogue, improves glycaemic control and […]

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The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes.

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Abstract: Current efforts to prevent progression from islet autoimmunity to type 1 diabetes largely focus on immunomodulatory approaches. However, emerging data suggest that the development of diabetes in islet autoantibody-positive […]

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Association of Serum Markers of Oxidative Stress With Incident Major Cardiovascular Events, Cancer Incidence and All-Cause Mortality in Type 2 Diabetes Patients: Pooled Results From Two Cohort Studies.

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Abstract: Oxidative stress plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). However, associations of biomarkers of oxidative stress with diabetes complications have not yet been […]

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Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study).

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Abstract: Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster […]

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Cross-sectional and Prospective Associations of Actigraphy-Assessed Sleep Regularity With Metabolic Abnormalities: The Multi-Ethnic Study of Atherosclerosis.

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Abstract: To cross-sectionally and prospectively investigate the association between irregular sleep patterns, a potential marker for circadian disruption, and metabolic abnormalities.In the Multi-Ethnic Study of Atherosclerosis, participants completed 7-day actigraphy […]

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Genetic association study of eight steroid hormones and implications for sexual dimorphism of coronary artery disease.

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Abstract: Steroid hormones are important regulators of physiological processes in humans and are under genetic control. A link to coronary artery disease (CAD) is supposed.Our main objective was to identify […]

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The impact of GDF-15, a biomarker for metformin, on the risk of coronary artery disease, breast and colorectal cancer, and type 2 diabetes and metabolic traits: a Mendelian randomisation study.

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Abstract: Growth differentiation factor 15 (GDF-15), a suggested biomarker for metformin use, may explain the potential cardioprotective and anti-cancer properties of metformin. We conducted a Mendelian randomisation study to examine […]

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Association of Galectin-3 with Diabetes Mellitus in the Dallas Heart Study.

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Abstract: Galectin-3 is a novel biomarker associated with inflammation and fibrosis in cardiac, liver and renal disease. Galectin-3 is higher in overweight and obese individuals; whether an association with diabetes […]

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Disturbances in Insulin-Glucose Metabolism in Patients with Advanced Renal Disease with and without Diabetes.

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Abstract: Use of insulin in patients with diabetes and advanced chronic kidney disease (stages 4-5 CKD) is challenging and shows great variability among individuals. We explored the mechanisms underlying this […]

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Quantification of the capacity for cold-induced thermogenesis in young men with and without obesity.

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Abstract: Cold exposure increases energy expenditure and could have a role in combating obesity. To understand this potential, we determined the capacity for cold-induced thermogenesis (CIT), the energy expenditure increase […]

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SREBP Plays a Regulatory Role in LH/hCG Receptor mRNA Expression in Human Granulosa-Lutein cells.

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Abstract: LH/hCG receptor (LHR) expression has been shown to be regulated post-transcriptionally by LHR mRNA binding protein (LRBP) in rodent and human ovaries. LRBP was characterized as being mevalonate kinase. […]

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Diabetes in pregnancy and epigenetic mechanisms-how the first 9 months from conception might affect the child’s epigenome and later risk of disease.

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Diabetes in pregnancy is not only associated with increased risk of pregnancy complications and subsequent maternal metabolic disease, but also increases the risk of long-term metabolic disease in the offspring. […]

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Rethinking good cholesterol: a clinicians’ guide to understanding HDL.

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Low HDL cholesterol dyslipidaemia affects about half of people with type 2 diabetes and represents a major independent risk factor for atherosclerotic cardiovascular disease. The “good cholesterol” label was coined […]

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