Cord blood IGF-I, proinsulin, leptin, HMW adiponectin and ghrelin in short or skinny small-for-gestational-age infants.

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Small-for-gestational-age (SGA) is an indicator of poor fetal growth “programming” an elevated risk of type 2 diabetes in adulthood. Little is known about early life endocrine characteristics in SGA subtypes. […]

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Diabetes Knowledge and Metabolic Control in Type 1 Diabetes Starting with Continuous Glucose Monitoring: FUTURE-PEAK.

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To investigate whether diabetes knowledge and health literacy impact glycemic control after one year of intermittently scanned continuous glucose monitoring (isCGM) in people with type 1 diabetes (PWD1) ≥16 years.In […]

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In patients with controlled acromegaly, indices of glucose homeostasis correlate with IGF-1 levels rather than with type of treatment.

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Acromegaly is accompanied by abnormalities in glucose and lipid metabolism which improve upon treatment. Few studies have investigated whether these improvements differ between treatment modalities. This study aimed to compare […]

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High extracellular ATP levels released through pannexin-1 channels mediate inflammation and insulin resistance in skeletal muscle fibres of diet-induced obese mice.

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Skeletal muscle is a key target organ for insulin’s actions and is the main regulator of blood glucose. In obese individuals and animal models, there is a chronic low-grade inflammatory […]

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Characterizing a common CERS2 polymorphism in a mouse model of metabolic disease and in subjects from the Utah CAD Study.

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Genome-wide association studies have identified associations between a common single nucleotide polymorphism (SNP, rs267738) in CERS2 – a gene that encodes a (dihydro)ceramide synthase involved in the biosynthesis of very-long […]

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Hepatic Fat in Participants With and Without Incident Diabetes in the Diabetes Prevention Program Outcome Study.

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To characterize hepatic fat content and fatty liver prevalence, their determinants, and effect of interventions to prevent diabetes using computerized tomography in a cohort with prediabetes, in those developing diabetes […]

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Identification and Functional Characterization of Metabolites for Bone Mass in Peri-/Post-menopausal Chinese Women.

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Although metabolic profiles appear to play an important role in menopausal bone loss, the functional mechanisms by which metabolites influence bone mineral density (BMD) during menopause are largely unknown.We aimed […]

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Metabolic and psychological features are associated with weight loss 12 months after sleeve gastrectomy.

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Laparoscopic sleeve gastrectomy (LSG) is a recognized effective procedure of bariatric surgery but a poor response in weight loss may still represent a clinical problem. To date there are no […]

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Association between mid-life obesity, its metabolic consequences, cerebrovascular disease and cognitive decline.

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Chronic obesity is associated with several complications, including cognitive impairment and dementia. However, we have piecemeal knowledge of the mechanisms linking obesity to central nervous system damage. Among candidate mechanisms […]

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Cardiovascular Disease Risk Factors and Metabolic Morbidity in a Longitudinal Study of Congenital Adrenal Hyperplasia.

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Patients with congenital adrenal hyperplasia (CAH) are exposed to hyperandrogenism and supraphysiologic glucocorticoids, both can increase risk of metabolic morbidity.Our aim was to evaluate cardiovascular and metabolic morbidity risk in […]

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Biochemical Parameters of Diabetes Ketoacidosis in patients with End-Stage Kidney Disease and Preserved Renal Function.

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Differences in biochemical parameters of diabetic ketoacidosis in patients with end-stage kidney disease (ESKD) has not been established. Accordingly, we assessed the relationship between degree of metabolic acidosis and ß […]

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Lifestyle intervention improves prothrombotic coagulation profile in individuals at high-risk for type 2 diabetes.

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Patients with obesity and insulin resistance are at higher risk for arterial and venous thrombosis due to a prothrombotic state. If this is reversible by lifestyle intervention was addressed in […]

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Cardiovascular, Renal, and Metabolic Outcomes of Dapagliflozin Versus Placebo in a Primary Cardiovascular Prevention Cohort: Analyses From DECLARE-TIMI 58.

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International guidelines propose prescribing sodium-glucose cotransporter 2 (SGLT2) inhibitors to patients with type 2 diabetes (T2D) as secondary prevention in patients with established atherosclerotic cardiovascular disease (ASCVD) or for primary […]

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Newborn Adiposity and Cord Blood C-Peptide as Mediators of the Maternal Metabolic Environment and Childhood Adiposity.

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Excessive childhood adiposity is a risk factor for adverse metabolic health. The objective was to investigate associations of newborn body composition and cord C-peptide with childhood anthropometrics and explore whether […]

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Fat mass accretion from birth to 5 years and metabolic homeostasis in childhood: The Healthy Start Study.

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It is unclear how fat mass accretion in early life is related to glucose-insulin homeostasis.Examine associations of fat and fat-free mass accretion from birth to early childhood with glucose-insulin homeostasis […]

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PREVENT: A Randomized, Placebo-Controlled Crossover Trial of Avexitide for Treatment of Post-Bariatric Hypoglycemia.

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Post-bariatric hypoglycemia (PBH), characterized by enteroinsular axis overstimulation and hyperinsulinemic hypoglycemia, is a complication of bariatric surgery for which there is no approved therapy.To evaluate efficacy and safety of avexitide […]

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Fasting plasma GLP-1 associates with overweight/obesity and cardiometabolic risk factors in children and adolescents.

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The importance of fasting GLP-1 in altered metabolic outcomes has been questioned.To assess if fasting GLP-1 differs in children and adolescents with overweight/obesity compared to a population-based reference, and whether […]

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Metabolic signatures of genetically elevated vitamin D among Chinese: observational and Mendelian randomization study.

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Observational studies have suggested that higher circulating 25-hydroxyvitamin D [25(OH)D] levels were associated with favorable serum lipids and related metabolites. However, if such observations reflect causality remains unclear.We aimed to […]

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Dapagliflozin and urine metabolome in patients with type 2 diabetes.

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Inhibitors of sodium-glucose cotransporters-2 have cardio- and renoprotective properties. However, the underlying mechanisms remain indeterminate.To evaluate the effect of dapagliflozin on renal metabolism assessed by urine metabolome analysis in patients […]

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Circulating chemerin level is associated with metabolic, biochemical, and hematological parameters – a population-based study.

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This study aims to analyze the association of chemerin levels with several metabolic, biochemical and hematological parameters in a large Taiwanese population with relative healthy status.Cross-sectional study.Data of 4101 healthy […]

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Insulin resistance in congenital adrenal hyperplasia is compensated for by reduced insulin clearance.

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Congenital Adrenal Hyperplasia (CAH) patients have potential normal longevity. However, a greater risk for cardiovascular disease has been reported. Insulin resistance and hyperinsulinemia have been described in CAH patients, whereas […]

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Pitfalls In Performing And Interpreting Inferior Petrosal Sinus Sampling: Personal Experience And Literature Review.

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Inferior petrosal sinus sampling (IPSS) helps differentiate the source of ACTH-dependent hypercortisolism in patients with inconclusive biochemical testing and imaging, and is considered the gold standard for distinguishing Cushing disease […]

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Plasma lipidomic profiles and risk of diabetes: two prospective cohorts of HIV-infected and HIV-uninfected individuals.

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Antiretroviral therapy (ART) use is associated with disrupted lipid and glucose metabolism in people with HIV-infection. We aimed to identify plasma lipid species associated with risk of diabetes in the […]

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Association between obstructive sleep apnea and metabolic abnormalities in patients with hypertrophic cardiomyopathy.

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Metabolic abnormalities have been associated with long-term cardiac mortality in patients with hypertrophic cardiomyopathy (HCM). Obstructive sleep apnea (OSA) is a risk factor for metabolic abnormalities in general populations, but […]

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