Weight Loss and Serum Lipids in Overweight and Obese Adults: A Systematic Review and Meta-analysis.

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Excess adipose tissue is associated with an abnormal lipid profile that may improve with weight reduction. In this meta-analysis, we aimed to estimate the magnitude of change in lipid parameters […]

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Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-Analysis.

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Hyperthyroidism is associated with low levels of cholesterol and triglycerides, and hypothyroidism is associated with hypercholesterolemia and hypertriglyceridemia.The aim of this systematic review was to investigate the impact of therapy […]

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Intact & C-terminal FGF-23 Assays- Do Kidney Function, Inflammation, & Iron Status Influence Relationships with Outcomes?

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Higher fibroblast growth factor-23 (FGF23) concentrations are associated with heart failure and mortality in diverse populations, but the strengths of associations differ markedly depending upon which assay is used.We sought […]

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Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline.

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This guideline will provide the practicing endocrinologist with an approach to assessment and treatment of dyslipidemia in patients with endocrine diseases, with the objective of prevention of cardiovascular events and […]

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Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases.

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Prospective observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; however, randomised controlled trials, have often reported neutral findings. […]

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Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity.

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Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there […]

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Effects of thyroid function on phosphodiester concentrations in skeletal muscle and liver: An in vivo NMRS study.

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Thyroid function is clinically evaluated by determination of circulating concentrations of TSH and fT4. However, a tissue-specific effector substrate of thyroid function is lacking. Energy-rich phosphorus-containing metabolites (PM) and phospholipids […]

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Surgical and pharmacological outcomes in acromegaly: Real-life data from the Mexican Acromegaly Registry.

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Acromegaly registries constitute a valuable source of therapeutic outcome information in real-life.To analyze surgical and pharmacological outcomes in the Mexican Acromegaly Registry (MAR).Data was extracted from the MAR informatic platform. […]

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Inferior adrenal artery PI in fetuses with IUGR: value indicating early blood redistribution and steroidogenic response.

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To characterize the inferior adrenal artery (IAA) pulsatility index (PI) in intrauterine growth-restricted (IUGR) fetuses without brain sparing.Twenty-three IUGR fetuses with a normal Doppler cerebroplacental ratio (CPR) and 23 normal […]

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Predictors of chronic LH-testosterone axis suppression in male macroprolactinomas with normoprolactinemia on cabergoline.

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Data regarding prevalence, predictors, and mechanisms of persistent hypogonadotropic hypogonadism (HH) in males with a macroprolactinoma who achieve normoprolactinemia on dopamine-agonist therapy is limited. None of the previous studies provide […]

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Association of the obesity paradox with objective physical activity in patients at high risk of sudden cardiac death.

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To investigate the obesity paradox and its interrelationship with objective physical activity (PA) in patients at high risk of sudden cardiac death (SCD).782 patients with implantable cardioverter-defibrillators (ICDs)/cardiac resynchronization therapy […]

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Maternal obesity influences placental nutrient transport, inflammatory status and morphology in human term placenta.

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Maternal obesity has a significant impact on placental development. However, this impact on placenta’s structure and function (i.e. nutrient transport, and hormone and cytokine production) is a controversial subject.We hypothesized […]

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Inhibition of BRAF Sensitizes Thyroid Carcinoma to Immunotherapy by Enhancing TsMHC-II-mediated Immune Recognition.

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Multiple mechanisms play roles in restricting the ability of T-cells to recognize and eliminate tumor cells.To identify immune escape mechanisms involved in papillary thyroid carcinoma (PTC) to optimize immunotherapy.iTRAQ analysis […]

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Genome-wide association for HbA1c in Malay identified deletion on SLC4A1 that influences HbA1c independent of glycemia.

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HbA1c level is used to screen and diagnose diabetes. Genetic determinants of HbA1c can vary across populations and many of the genetic variants influencing HbA1c level were specific to populations.To […]

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The oncocytic variant of poorly differentiated thyroid carcinoma shows a specific immune-related gene expression profile.

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Poorly differentiated thyroid cancer (PDTC) is a rare, follicular cell-derived neoplasm with unfavorable prognosis. The oncocytic variant of PDTC may be associated with even more adverse outcome than classical PDTC […]

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Predictors of the Response to Dopaminergic Therapy in Patients with Prolactinoma.

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Withdrawal of dopamine agonist (DA) therapy in patients with prolactinoma who are controlled by a small dose of medication is recommended by several guidelines. So far, the likelihood of reaching […]

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The 15-epilipoxin-A4 pathway (ATL) with prophylactic aspirin in preventing preeclampsia: a longitudinal-cohort study.

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The benefit of aspirin in preventing preeclampsia is increasingly recognised, however, its mechanism of action remains unclear. Non-obstetric studies have described an anti-inflammatory effect of aspirin through 15-epilipoxin-A4(ATL). However, the […]

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Intensity modulated radiotherapy (IMRT) for pituitary somatotroph adenomas.

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To summarize our experience in the treatment of pituitary somatotroph adenomas by fractionated intensity modulated radiotherapy (IMRT), describe the treatment outcomes and determine predictors.Patients with pituitary somatotroph adenoma treated by […]

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Approach to the Treatment of a Patient with an Aggressive Pituitary Tumor.

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A small subset of pituitary adenomas grow despite maximal treatment with standard therapies; namely, surgery and radiotherapy. These aggressive tumors demonstrate two patterns of growth: they may be locally aggressive […]

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Loneliness and type 2 diabetes incidence: findings from the English Longitudinal Study of Ageing.

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Loneliness is associated with all-cause mortality and coronary heart disease. However, the prospective relationship between loneliness and type 2 diabetes onset is unclear.We conducted a longitudinal observational population study with […]

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A human randomized controlled trial comparing metabolic responses to single and repeated hypoglycemia in type 1 diabetes.

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Hypoglycemia hinders optimal glycemic management in type 1 diabetes (T1D). Long diabetes duration and hypoglycemia impair hormonal counterregulatory responses to hypoglycemia. Our study was designed to test whether i) the […]

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The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor.

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The natriuretic effect of GLP-1 in humans is independent of changes in renal plasma flow (RPF) and glomerular filtration rate (GFR) but may involve suppression of angiotensin II (ANG II) […]

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A human randomized controlled trial comparing metabolic responses to single and repeated hypoglycemia in type 1 diabetes.

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Hypoglycemia hinders optimal glycemic management in type 1 diabetes (T1D). Long diabetes duration and hypoglycemia impair hormonal counterregulatory responses to hypoglycemia. Our study was designed to test whether i) the […]

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The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor.

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The natriuretic effect of GLP-1 in humans is independent of changes in renal plasma flow (RPF) and glomerular filtration rate (GFR) but may involve suppression of angiotensin II (ANG II) […]

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Associations of BMI and Serum Urate with Developing Dementia: A Prospective Cohort Study.

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Recent studies suggested that higher BMI and serum urate levels were associated with lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate and BMI […]

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Plasma Epinephrine Contributes to the Development of Experimental Hypoglycemia-Associated Autonomic Failure.

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Recurrent hypoglycemia blunts counter-regulatory responses to subsequent hypoglycemic episodes, a syndrome known as hypoglycemia-associated autonomic failure (HAAF). Since adrenergic receptor blockade has been reported to prevent HAAF, we investigated whether […]

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Association of Vitamin D Pathway Gene CYP27B1 and CYP2R1 Polymorphisms with Autoimmune Endocrine Disorders: A Meta-Analysis.

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Studies on organ-specific autoimmune endocrine disorders showed correlations between disease risks and vitamin D pathways gene variants, such as CYP27B1 rs10877012 and rs4646536, or CYP2R1 rs10741657 single nucleotide polymorphisms. However, […]

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Bone development in transgender adolescents treated with GnRH analogues and subsequently gender affirming hormones.

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Hormonal interventions in adolescents with gender dysphoria may have adverse effects such as reduced bone mineral accrual.To describe bone mass development in adolescents with gender dysphoria treated with gonadotropin-releasing hormone […]

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