Characterizing the clinical and genetic spectrum of polycystic ovary syndrome in electronic health records.

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Polycystic ovary syndrome (PCOS) is one of the leading causes of infertility, yet current diagnostic criteria are ineffective at identifying patients whose symptoms reside outside strict diagnostic criteria. As a […]

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Baseline levels of seminal reactive oxygen species predict improvements in sperm function following anti-oxidant therapy in men with infertility.

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Poor sperm function is a major cause of infertility. There is no drug therapy to improve sperm function. Semen oxidative stress is a recently identified pathway for sperm damage. Commercial […]

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Reproduction Function in Male Patients with Bardet Biedl Syndrome.

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Bardet-Biedl syndrome (BBS) is a ciliopathy with a wide spectrum of symptoms due to primary cilia dysfunction including genitourinary developmental anomalies as well as impaired reproduction particularly in males. Primary […]

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The role of hormone stimulation in men with non-obstructive azoospermia undergoing surgical sperm retrieval.

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Non obstructive azoospermia, (NOA) is the most common cause of azoospermia. NOA is characterised by hypergonadotrophic hypogonadism, testicular failure, and impaired spermatogenesis. The recent development of surgical sperm retrieval techniques […]

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Fertility Options for the Transgender and Gender Non-binary Patient.

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Comprehensive care for transgender and gender non-binary patients has been a priority established by the World Professional Association for Transgender Health (WPATH). Because pubertal suppression, gender-affirming hormone therapy, and antiandrogen […]

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Increased risk of metabolic dysfunction in children conceived by assisted reproductive technology.

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Assisted reproductive technology (ART) is the most widely used treatment for infertility and has resulted in millions of births worldwide. The safety of the offspring has been of the utmost […]

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Fertility and pregnancy outcomes in women with polycystic ovary syndrome following bariatric surgery.

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Restoration of ovulation is quite common in women with polycystic ovary syndrome (PCOS) after surgically-induced weight loss. Whether or not this results in an improvement of PCOS-associated infertility is uncertain.To […]

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Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?

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Implantation is a reproductive bottleneck in women, regulated by fluctuations in ovarian steroid hormone concentrations. However, other nuclear receptor ligands are modifiers of endometrial differentiation leading to successful pregnancy. In […]

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The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility.

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To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception.Observational cohort study.A total of 49 hospitals across the United Kingdom between […]

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Effects of IVF therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.

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In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and […]

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Obesity, polycystic ovary syndrome and infertility: a new avenue for GLP-1 receptor agonists.

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Obesity is responsible for an increased risk of sub-fecundity and infertility. Obese women show poorer reproductive outcomes regardless of the mode of conception, and higher body mass index (BMI) is […]

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Prospects for FSH Treatment of Male Infertility.

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Despite the new opportunities provided by assisted reproduction techniques, male infertility treatment is far from being optimized. One possibility, based on pathophysiological evidence, is to stimulate spermatogenesis with gonadotropins.We conducted […]

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Burdens and awareness of adverse self-reported lifestyle factors in men with sub-fertility: a cross-sectional study in 1149 men.

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There are no current pharmacological therapies to improve sperm quality in men with sub-fertility. Reducing the exposure to lifestyle risk factor (LSF) is currently the only intervention for improving sperm […]

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A novel phenotype combining primary ovarian insufficiency growth retardation and pilomatricomas with MCM8 mutation.

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Primary Ovarian insufficiency (POI) affects 1% of women under 40 years and leads most often to definitive infertility with adverse health outcomes. Very recently, genes involved in DNA repair have […]

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CTG expansion in the DMPK gene: semen quality assessment and outcome of Preimplantation Genetic Diagnosis.

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Myotonic dystrophy (DM) is an autosomal dominant disorder characterized mainly by myotonia but also by primary hypogonadism. No study has reported on fertility management of patients affected by DM type […]

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Infertility, gravidity, and risk of diabetes among high-risk women in the Diabetes Prevention Program Outcomes Study.

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The extent to which infertility and pregnancy independently increase risk of diabetes and subclinical atherosclerosis is not known.We conducted a secondary analysis of Diabetes Prevention Program (DPP) and the DPP […]

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Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment: A Randomized Clinical Trial.

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Dietary supplements marketed for male fertility commonly contain folic acid and zinc based on limited prior evidence for improving semen quality. However, no large-scale trial has examined the efficacy of […]

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BMPR1A and BMPR1B missense mutations cause primary ovarian insufficiency.

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Primary ovarian insufficiency (POI) is a frequently occurring disorder affecting ~1% of women under 40 years of age. POI, which is characterized by the premature depletion of ovarian follicles and […]

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Low Circulating Levels of miR-451a in Girls with Polycystic Ovary Syndrome: Different Effects of Randomized Treatments.

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Polycystic ovary syndrome (PCOS) is a prevalent disorder in adolescent girls, purportedly driven by hepato-visceral fat excess, and often followed by subfertility and type 2 diabetes.we studied the baseline miRNA […]

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Human Endometrial Transcriptome and Progesterone Receptor Cistrome Reveal Important Pathways and Epithelial Regulators.

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Poor uterine receptivity is one major factor leading to pregnancy loss and infertility. Understanding the molecular events governing successful implantation is hence critical in combating infertility.To define PGR-regulated molecular mechanisms […]

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Fertility and pregnancy in women with hypopituitarism: a systematic literature review.

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Human reproduction is mainly governed from the hypothalamic-adrenal-gonadal (HPG) axis, which controls both ovarian morphology and function. Disturbances in the secretion of other anterior pituitary hormones (and their respective endocrine […]

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Diabetes: a metabolic and reproductive disorder in women.

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Reproductive dysfunction is a common but little studied complication of diabetes. The spectrum of reproductive health problems in diabetes is broad, and encompasses delayed puberty and menarche, menstrual cycle abnormalities, […]

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Fertility in Adolescents with Klinefelter Syndrome: A Survey of Current Clinical Practice.

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Abstract: Progress has been made in determining the fertility timeline and potential in adolescents with Klinefelter Syndrome; however, medical professionals are currently left without protocols to guide treatment.To evaluate the […]

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Regulation of Insulin-Like Growth Factor 2 by Oocyte-Secreted Factors in Primary Human Granulosa Cells.

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Abstract: Human granulosa cells (hGCs) produce and respond to insulin-like growth factor 2 (IGF2) but whether the oocyte participates in IGF2 regulation in humans is unknown.To determine the role of […]

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Associations between anti-mullerian hormone and cardio-metabolic health in reproductive age women are explained by body mass index.

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Abstract: The relationship between reproductive and cardio-metabolic aging is unclear. It is unknown if the relationship differs across different clinical populations.To determine whether markers of ovarian reserve are associated with […]

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Infertility and Mortality.

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Abstract: Infertility affects 1 in 10 American reproductive-age women. The impact of this disease beyond the reproductive years is largely unknown.To determine the association of infertility history with all-cause and […]

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