Progression of Diabetic Retinopathy and Predictors of Its Development and Progression During Pregnancy in Patients With Type 1 Diabetes: A Report of 499 Pregnancies.

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Pregnancy has been associated with development and progression of diabetic retinopathy (DR), but incidence of DR remains unclear. We assessed DR progression rate and its predictors during pregnancies in patients […]

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Significance of Discordant Results between Confirmatory Tests in Diagnosis of Primary Aldosteronism.

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Current clinical guidelines recommend confirmation of positive result in at least one confirmatory test in the diagnosis of primary aldosteronism (PA). Clinical implication of multiple confirmatory tests has not been […]

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Guideline recommendations and the positioning of newer drugs in type 2 diabetes care.

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Cardiovascular outcome trials in patients with type 2 diabetes at high cardiovascular risk have led to remarkable advances in our understanding of the effectiveness of GLP-1 receptor agonists and SGLT2 […]

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Recurrence rate of sporadic pheochromocytomas after curative adrenalectomy – a systematic review and meta-analysis.

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Evidence on follow-up duration for patients with sporadic pheochromocytomas is absent and current guidelines of the European Society of Endocrinology (ESE), American Association of Clinical Endocrinologists and Endocrine Surgeons (AACE/AAES) […]

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Approach to the Patient: Management of the Post-Bariatric Surgery Patient With Weight Regain.

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Weight regain (WR) after bariatric surgery is emerging as a common clinical problem due to the increase in the number of procedures performed. Early interventions are necessary to curtail the […]

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Weight gain after thyroidectomy: a systematic review and meta-analysis.

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Weight gain is a major driver of dissatisfaction and decreased quality of life in patients with hypothyroidism. Data on the changes in body weight following thyroidectomy are conflicting.To perform a […]

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Sustained Impact of Real-Time Continuous Glucose Monitoring in Adults With Type 1 Diabetes on Insulin Pump Therapy: Results After the 24-Month RESCUE Study.

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In recent years, a growing number of people with type 1 diabetes have gained access to real-time continuous glucose monitoring (rtCGM). Long-term benefits of rtCGM are unclear because of a […]

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Risk stratification of adrenal masses by [18 F]FDG PET/CT: changing tactics.

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[18 F]FDG PET/CT improves adrenal tumour characterization. However, there is still no consensus regarding the optimal imaging biomarkers of malignancy.To assess the performance of Tumour SUVmax :Liver SUVmax for malignancy-risk […]

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Iatrogenic hypoglycaemia following glucose-insulin infusions for the treatment of hyperkalaemia.

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To study the incidence of, and risk factors for, iatrogenic hypoglycaemia following GwI infusion in our institution. Context Hyperkalaemia is a life-threatening biochemical abnormality. Glucose-with-insulin (GwI) infusions form standard management, […]

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Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline.

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This guideline will provide the practicing endocrinologist with an approach to assessment and treatment of dyslipidemia in patients with endocrine diseases, with the objective of prevention of cardiovascular events and […]

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Predictors of the Response to Dopaminergic Therapy in Patients with Prolactinoma.

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Withdrawal of dopamine agonist (DA) therapy in patients with prolactinoma who are controlled by a small dose of medication is recommended by several guidelines. So far, the likelihood of reaching […]

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A systematic review of anti-androgens and feminisation in transgender women.

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Anti-androgens are frequently used with estradiol in transgender women seeking feminisation. Anti-androgens act by various mechanisms to decrease the production or effects of testosterone, but it is unclear which anti-androgen […]

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The Evolution of the Primary Aldosteronism Syndrome: Updating the Approach.

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New approaches are needed to address the evolution of the primary aldosteronism syndrome and to increase its recognition. Herein, we review evidence indicating that primary aldosteronism is a prevalent syndrome […]

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Gestational diabetes: opportunities for improving maternal and child health.

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Gestational diabetes, the most common medical disorder in pregnancy, is defined as glucose intolerance resulting in hyperglycaemia that begins or is first diagnosed in pregnancy. Gestational diabetes is associated with […]

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Distant metastasis in pediatric and adolescent differentiated thyroid cancer: Clinical outcomes and risk factor analyses.

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The specific characteristics of pediatric and adolescent differentiated thyroid cancer (DTC) is the more frequent occurrence of distant metastasis (DM) compared with adult DTC.To investigate the clinical outcomes of DM […]

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Management and appropriate use of diazoxide in infants and children with hyperinsulinism.

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The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade. Diazoxide is the only FDA-approved pharmacologic treatment for neonatal hypoglycemia caused by hyperinsulinism (HI). Recent […]

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Normocalcemic Primary Hyperthyroidism: An Update on Diagnostic and Management Challenges.

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Normocalcemic primary hyperparathyroidism likely represents a condition that may evolve into its hypercalcemic counterpart and recent studies have shown that patients can present with intermittent hypercalcemia. This milder biochemical entity […]

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Evaluation of the Role of Thyroid Scintigraphy in the Differential Diagnosis of Thyrotoxicosis.

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A differential diagnosis of thyrotoxicosis is crucial as the treatment of the main causes of this condition can vary significantly. Recently published diagnostic guidelines on thyrotoxicosis embrace the presence of […]

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A personalised screening strategy for diabetic retinopathy: a cost-effectiveness perspective.

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In this study we examined the cost-effectiveness of three different screening strategies for diabetic retinopathy: using a personalised adaptive model, annual screening (fixed intervals), and the current Dutch guideline (stratified […]

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Prevalence of Latent and Overt Polyautoimmunity in Autoimmune Thyroid Disease: A Systematic Review and Meta-analysis.

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Thyroid autoimmunity is the most frequent condition involved in polyautoimmunity (PolyA). However, the frequency of latent and overt PolyA in patients with autoimmune thyroid disease (AITD) as the index condition […]

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International histopathology consensus for unilateral primary aldosteronism.

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Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA).Unilateral PA is the most common surgically-treated form of hypertension. Morphologic examination combined with […]

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Relation of Health-related Quality of life to near final height and body composition in adolescents with chronic endocrinopathies during transition period.

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We evaluated sequelae of disease and therapy in adolescents with chronic endocrinopathies using a medical and psychological work-up to record Health related Quality of Life (HRQoL), near final heights (NFH), […]

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Challenges in preventing bone loss induced by aromatase inhibitors.

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Aromatase inhibitors have become a mainstay in the adjuvant treatment regime in postmenopausal women with hormone-receptor positive breast cancer. While many of these patients have an excellent long-term prognosis, adverse […]

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Predicting 5- and 10-Year Mortality Risk in Older Adults With Diabetes.

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Several diabetes clinical practice guidelines suggest that treatment goals may be modified in older adults on the basis of comorbidities, complications, and life expectancy. The long-term benefits of treatment intensification […]

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The 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guidelines on the Management of Blood Cholesterol in Diabetes.

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The American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines recently published its 2018 recommendations on management of LDL cholesterol (LDL-C) in people with diabetes. For primary […]

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COVID-19 in people living with diabetes: An international consensus.

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The COVID-19 pandemic has added an enormous toll to the existing challenge of diabetes care world-wide. A large proportion of patients with COVID-19 requiring hospitalization and/or succumbing to the disease […]

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The Association Between HbA1c and Time in Hypoglycemia During CGM and Self-Monitoring of Blood Glucose in People With Type 1 Diabetes and Multiple Daily Insulin Injections: A Randomized Clinical Trial (GOLD-4).

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According to recent guidelines, individuals with type 1 diabetes should spend <4.0% per day with glucose levels <3.9 mmol/L (<70 mg/dL) and <1.0% per day with glucose levels <3.0 mmol/L […]

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