High prevalence and a long delay in the diagnosis of primary aldosteronism among patients with young-onset hypertension.

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Despite being the most common cause of secondary hypertension, prevalence of primary aldosteronism (PA) among patients with young-onset hypertension (YH – age of hypertension onset <40 years) remains poorly-studied. We […]

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Exendin-4 based imaging in insulinoma localization: systematic review and meta-analysis.

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Glucagon-like peptide-1 receptor (GLP-1 R) based imaging has shown higher sensitivity for insulinoma localization as compared to other anatomic/functional imaging.We reviewed the published English literature for GLP-1 R targeted imaging […]

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Early decline of androgen levels in healthy adult men: an effect of aging per se? A prospective cohort study.

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Androgen levels have been shown to decline in aging men. However, there is no consensus on the effect of aging, (changes in) BMI, lifestyle factors and intercurrent disease.Investigating longitudinal changes […]

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Development of a prediction score to avoid confirmatory testing in patients with suspected primary aldosteronism.

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The diagnostic work-up of primary aldosteronism (PA) includes screening and confirmation steps. Case confirmation is time-consuming, expensive, and there is no consensus on tests and thresholds to be used. Diagnostic […]

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Selective use of radioactive iodine therapy for papillary thyroid cancers with low or lower-intermediate recurrence risk.

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Current guidelines recommend a selective use of radioiodine treatment (RAI) for papillary thyroid cancer (PTC).To determine how policy changes affect the use of RAI and the short-term outcomes of patients.Retrospective […]

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Adoption of Active Surveillance for Very Low-Risk Differentiated Thyroid Cancer in the United States: A National Survey.

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Active surveillance (AS) of thyroid cancer with serial ultrasounds is a newer management option in the United States.To understand factors associated with adoption of AS.We surveyed endocrinologists and surgeons in […]

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Effects of empagliflozin on estimated extracellular volume, estimated plasma volume, and measured glomerular filtration rate in patients with heart failure (Empire HF Renal): a prespecified substudy of a double-blind, randomised, placebo-controlled trial.

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SGLT2 inhibitors are a promising treatment option in patients with heart failure and reduced ejection fraction. We aimed to investigate the effects of empagliflozin on estimated extracellular volume, estimated plasma […]

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Evaluating tertiary adrenal insufficiency in rheumatology patients on long-term systemic glucocorticoid treatment.

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Patients with rheumatic diseases are often treated with prolonged, high-dose systemic glucocorticoids which can cause hypothalamic-pituitary-adrenal (HPA) axis suppression and development of tertiary adrenal insufficiency. Adrenal insufficiency carries the risk […]

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Clinical and biochemical discriminants between Functional Hypothalamic Amenorrhoea (FHA) and Polycystic Ovary Syndrome (PCOS).

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Secondary oligo/amenorrhoea occurs in 3-5% of women of reproductive age. The two most common causes are Polycystic Ovary Syndrome (PCOS) (2-13%) and Functional Hypothalamic Amenorrhoea (FHA) (1-2%). Whilst both conditions […]

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Advanced Liver Fibrosis Is Common in Patients With Type 2 Diabetes Followed in the Outpatient Setting: The Need for Systematic Screening.

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Assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and of liver fibrosis associated with nonalcoholic steatohepatitis in unselected patients with type 2 diabetes mellitus (T2DM).A total of 561 patients […]

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Natural History of Thyroid Disease in Children with PTEN Hamartoma Tumor Syndrome.

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Thyroid ultrasound screening is recommended in children with PTEN hamartoma tumor syndrome (PHTS) due to increased risk of thyroid neoplasia, but the natural history of thyroid disease in children with […]

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Assessment of medication adherence in children and adults with congenital adrenal hyperplasia and the impact of knowledge and self-management.

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Congenital adrenal hyperplasia (CAH) is caused by a deficiency of one of the enzymes required for cortisol biosynthesis. The disease is classified as either classic (severe phenotype), subdivided into simple-virilizing […]

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Roux-en-Y Gastric Bypass Increases Glycemic Variability and Time in Hypoglycemia in Patients With Obesity and Prediabetes or Type 2 Diabetes: A Prospective Cohort Study.

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Roux-en-Y gastric bypass (RYGB) is an established treatment for type 2 diabetes and obesity. The study objective was to establish RYGB’s effects on glycemic variability (GV) and hypoglycemia.This was a […]

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Roux-en-Y Gastric Bypass Increases Glycemic Variability and Time in Hypoglycemia in Patients With Obesity and Prediabetes or Type 2 Diabetes: A Prospective Cohort Study.

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Roux-en-Y gastric bypass (RYGB) is an established treatment for type 2 diabetes and obesity. The study objective was to establish RYGB’s effects on glycemic variability (GV) and hypoglycemia.This was a […]

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PET detectives: Molecular imaging for phaeochromocytomas and paragangliomas in the genomics era.

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Phaeochromocytomas and paragangliomas (PPGLs) are rare tumours that arise from the adrenal medulla or extra-adrenal sympathetic or parasympathetic paraganglia. Recent advances in genetics have greatly enhanced understanding of the pathogenesis […]

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Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program.

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Asthma is a major public health problem worldwide and is associated with excess morbidity, mortality, and economic costs associated with lost productivity. The National Asthma Education and Prevention Program has […]

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Efficacy of micronised progesterone for sleep: a systematic review and meta-analysis of randomised controlled trial data.

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Pre-clinical data has shown progesterone metabolites improve sleep parameters through positive allosteric modulation of the GABA-A receptor. We undertook a systematic review and meta-analysis of randomised controlled trials to assess […]

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Improvement in symptoms and health-related quality of life in acromegaly patients: a systematic review and meta-analysis.

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While biochemical response is often used as primary study outcome, improvement in symptoms and health-related quality of life (HRQoL) is the relevant goal for patients to consider treatment successful. We […]

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Acceleration of gastric emptying by insulin-induced hypoglycemia is dependent on the degree of hypoglycemia.

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Hypoglycemia is a major barrier to optimal glycemic control in insulin-treated diabetes. Recent ADA guidelines have sub-categorized ‘non-severe’ hypoglycemia into level 1 (<3.9 mmol/L) and 2 (<3 mmol/L) hypoglycemia. Gastric […]

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Acceleration of gastric emptying by insulin-induced hypoglycemia is dependent on the degree of hypoglycemia.

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Hypoglycemia is a major barrier to optimal glycemic control in insulin-treated diabetes. Recent ADA guidelines have sub-categorized ‘non-severe’ hypoglycemia into level 1 (<3.9 mmol/L) and 2 (<3 mmol/L) hypoglycemia. Gastric […]

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Update on PCOS: Consequences, Challenges and Guiding Treatment.

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Polycystic Ovary Syndrome (PCOS) is one of the most common reproductive endocrine disorders in women and despite this, diagnostic challenges, delayed diagnosis and less than optimal treatment regimens plague the […]

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Progression of Diabetic Retinopathy and Predictors of Its Development and Progression During Pregnancy in Patients With Type 1 Diabetes: A Report of 499 Pregnancies.

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Pregnancy has been associated with development and progression of diabetic retinopathy (DR), but incidence of DR remains unclear. We assessed DR progression rate and its predictors during pregnancies in patients […]

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Significance of Discordant Results between Confirmatory Tests in Diagnosis of Primary Aldosteronism.

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Current clinical guidelines recommend confirmation of positive result in at least one confirmatory test in the diagnosis of primary aldosteronism (PA). Clinical implication of multiple confirmatory tests has not been […]

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Guideline recommendations and the positioning of newer drugs in type 2 diabetes care.

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Cardiovascular outcome trials in patients with type 2 diabetes at high cardiovascular risk have led to remarkable advances in our understanding of the effectiveness of GLP-1 receptor agonists and SGLT2 […]

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Recurrence rate of sporadic pheochromocytomas after curative adrenalectomy – a systematic review and meta-analysis.

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Evidence on follow-up duration for patients with sporadic pheochromocytomas is absent and current guidelines of the European Society of Endocrinology (ESE), American Association of Clinical Endocrinologists and Endocrine Surgeons (AACE/AAES) […]

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Approach to the Patient: Management of the Post-Bariatric Surgery Patient With Weight Regain.

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Weight regain (WR) after bariatric surgery is emerging as a common clinical problem due to the increase in the number of procedures performed. Early interventions are necessary to curtail the […]

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Weight gain after thyroidectomy: a systematic review and meta-analysis.

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Weight gain is a major driver of dissatisfaction and decreased quality of life in patients with hypothyroidism. Data on the changes in body weight following thyroidectomy are conflicting.To perform a […]

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Sustained Impact of Real-Time Continuous Glucose Monitoring in Adults With Type 1 Diabetes on Insulin Pump Therapy: Results After the 24-Month RESCUE Study.

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In recent years, a growing number of people with type 1 diabetes have gained access to real-time continuous glucose monitoring (rtCGM). Long-term benefits of rtCGM are unclear because of a […]

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