Effect of Leptin Therapy on Survival in Generalized and Partial Lipodystrophy: A Matched Cohort Analysis.

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Data quantifying the impact of metreleptin therapy on survival in nonHIVrelated generalized lipodystrophy (GL) and partial lipodystrophy (PL) are unavailable.This study aimed to estimate the treatment effect of metreleptin on […]

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Plasma Cortisol and Risk of Atrial Fibrillation: A Mendelian Randomization Study.

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Atrial fibrillation (AF), cardiac arrhythmias and related risk factors are common in patients with Cushing’s syndrome, or clinical chronic hypercortisolism. While hypercortisolism may be associated with AF, this association has […]

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Role of Non-Thyroidal Illness Syndrome in Predicting Adverse Outcomes in COVID-19 Patients Predominantly of Mild to Moderate Severity.

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Existing studies reported the potential prognostic role of non-thyroidal illness syndrome (NTIS), characterized by low triiodothyronine (T3) with normal/low thyroid-stimulating hormone (TSH), mainly in severe COVID-19. None considered the significant […]

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Derivation and validation of a machine learning risk score using biomarker and electronic patient data to predict progression of diabetic kidney disease.

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Predicting progression in diabetic kidney disease (DKD) is critical to improving outcomes. We sought to develop/validate a machine-learned, prognostic risk score (KidneyIntelX™) combining electronic health records (EHR) and biomarkers.This is […]

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Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.

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Volanesorsen is an antisense oligonucleotide that targets hepatic apolipoprotein C-III synthesis and reduces plasma triglyceride concentration. The aim of this study was to explore the safety and efficacy of volanesorsen […]

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Oestrogen receptor α in T cells controls the T cell immune profile and glucose metabolism in mouse models of gestational diabetes mellitus.

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The imbalance between maternal insulin resistance and a relative lack of insulin secretion underlies the pathogenesis of gestational diabetes mellitus (GDM). Alterations in T cell subtypes and increased levels of […]

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Prescription of glucose-lowering therapies and risk of COVID-19 mortality in people with type 2 diabetes: a nationwide observational study in England.

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In patients with type 2 diabetes, hyperglycaemia is an independent risk factor for COVID-19-related mortality. Associations between pre-infection prescription for glucose-lowering drugs and COVID-19-related mortality in people with type 2 […]

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Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.

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A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. […]

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Prenatal exposure to bisphenols and phthalates and postpartum depression: The role of neurosteroid hormone disruption.

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Postpartum depression (PPD) is a serious psychiatric disorder. While causes remain poorly understood, perinatal sex hormone fluctuations are an important factor, and allopregnanolone in particular has emerged as a key […]

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A polygenic risk score to predict future adult short stature amongst children.

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Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height.To develop a polygenic risk score for adult height and evaluate its clinical utility.A […]

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Basal ganglia calcification is associated with local and systemic metabolic mechanisms in adult hypoparathyroidism.

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Hypoparathyroidism is characterized by low serum calcium, increased serum phosphorus, and inappropriately low or decreased serum parathyroid hormone, which may be associated with soft tissue calcification in the basal ganglia […]

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Denosumab reduces lesional Fluoride skeletal burden on Na[18F]F PET-CT in patients with Fibrous Dysplasia/McCune-Albright syndrome.

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The correlation between Fibrous Dysplasia/McCune-Albright syndrome (FD/MAS) skeletal disease burden on Na[18F]F-PET-CT and serum bone turnover markers (BTMs) was recently described. The effect of treatment on lesional fluoride burden in […]

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Exceptionality of Distant Metastases in Node-Negative Hereditary and Sporadic Medullary Thyroid Cancer: Lessons Learned.

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Risk factors of lymph node and distant metastases have rarely been analyzed in hereditary and sporadic medullary thyroid cancer (MTC) using large genetic-clinical data sets.This comprehensive investigation aimed to explore […]

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Diminishing value from multiple serial bone densitometry in women receiving anti-resorptive medication for osteoporosis.

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The value of serial bone mineral density (BMD) monitoring while on osteoporosis therapy is controversial.We determined the percentage of women classified as suboptimal-responders to therapy with anti-resorptive medications according to […]

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Population vitamin D stores are increasing in Tasmania and this is associated with less BMD loss over 10 years.

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Vitamin D deficiency is a common, modifiable determinant of musculoskeletal health. There are limited data that examine the longitudinal change in population 25-hydroxyvitamin D (25(OH)D) and none that evaluate the […]

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Recurrence-free survival analysis in locally advanced pheochromocytoma: first appraisal.

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Locally advanced pheochromocytoma (LAP) behavior remains unknown.To characterize this population and its recurrence-free survival (RFS).A retrospective multicentric study run within the ENDOCAN-COMETE network and GTE from 2003 to 2018.11 French […]

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The Enigma Of Persistent Symptoms In Hypothyroid Patients Treated With Levothyroxine: A Narrative Review.

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A significant minority of patients with hypothyroidism report persistent symptoms despite achieving normal thyroid biochemistry after levothyroxine (L-T4) replacement. Four principal lines of thinking, which are not mutually exclusive, may […]

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Bone Material Strength index as measured by Impact Microindentation is low in Patients with Primary Hyperparathyroidism.

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In primary hyperparathyroidism (PHPT) bone mineral density (BMD) is typically decreased in cortical bone and relatively preserved in trabecular bone. An increased fracture rate is observed however not only at […]

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Health-related quality of life in patients with early-detected central congenital hypothyroidism.

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Central congenital hypothyroidism (CH) requires lifelong medical treatment. The majority of children with central CH have multiple pituitary hormone deficiencies (MPHD), but in some cases central CH is isolated. Most […]

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Predictors of Bilateral Disease in Pediatric Differentiated Thyroid Cancer.

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Total thyroidectomy is recommended for children with papillary thyroid carcinoma, partly because of a high prevalence of bilateral disease. Identifying characteristics that predict bilateral disease might identify candidates for more […]

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Effect of flash glucose monitoring in adults with type 1 diabetes: a nationwide, longitudinal observational study of 14,372 flash users compared with 7691 glucose sensor naive controls.

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The aim of this work was to evaluate changes in glycaemic control (HbA1c) and rates of severe hypoglycaemia over a 2 year period after initiation of flash glucose monitoring (FM) in […]

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One year of GH treatment for growth failure in children with anorexia nervosa: a randomized placebo-controlled trial.

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Children with anorexia nervosa (AN) are at risk of adult height deficit due to prolonged low height velocity (HV).To investigate the effects of human growth hormone (GH) injections on HV […]

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Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity.

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We sought to determine putative relationships among improved mitochondrial respiration, insulin sensitivity and altered skeletal muscle lipids and metabolite signature in response to combined aerobic and resistance training in women […]

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