Patients with MEN1 are at an increased risk for venous thromboembolism VTE risk in MEN1.

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Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder predisposing to the development of multiple functional and non-functional neuroendocrine tumors (NETs). Only uncommon MEN1-associated functional NETs such as […]

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Increased body mass index is associated with a non-dilutional reduction in antimullerian hormone.

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Controversy exists regarding if and how body mass index (BMI) impacts antimullerian hormone (AMH) in women with and without polycystic ovary syndrome (PCOS). Understanding the BMI-AMH relationship has critical implications […]

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The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study.

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Depression is twice as common in individuals with type 2 diabetes as in the general population. However, it remains unclear whether hyperglycaemia and insulin resistance are directly involved in the […]

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Cost-effectiveness and efficacy of a novel combination regimen in acromegaly: a prospective, randomized trial.

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Combination therapy with somatostatin receptor ligand (SRL) plus pegvisomant for acromegaly patients is recommended after maximizing dose on monotherapy. Lower-dose combination regimens are not well-studied.To compare cost-effectiveness and efficacy of […]

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Marked Increase in Incident Gynecomastia: A 20-year National Registry Study 1998-2017.

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Gynecomastia, the proliferation of mammary glandular tissue in the male, is a frequent but little studied condition. Available prevalence data are based on selected patient populations or autopsy cases with […]

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Fertility and pregnancy outcomes in women with polycystic ovary syndrome following bariatric surgery.

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Restoration of ovulation is quite common in women with polycystic ovary syndrome (PCOS) after surgically-induced weight loss. Whether or not this results in an improvement of PCOS-associated infertility is uncertain.To […]

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Sino-European differences in the genetic landscape and clinical presentation of pheochromocytoma and paraganglioma.

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Pheochromocytomas and paragangliomas (PPGLs) are characterized by distinct genotype-phenotype relationships according to studies largely restricted to Caucasian populations.To assess for possible differences in genetic landscapes and genotype-phenotype relationships of PPGLs […]

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Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years: a prospective cohort study.

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The levels of adrenal androgens are increased through the action of steroidogenic enzymes with morphological changes in the adrenal zona reticularis.We investigated longitudinal changes in androgen levels and steroidogenic enzyme […]

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Improved Beta Cell Glucose Sensitivity Plays Predominant Role in the Decrease in HbA1c with Cana and Lira in T2DM.

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To examine the effect of combination therapy with canagliflozin plus liraglutide versus each agent alone on beta cell function in type 2 diabetes mellitus (T2DM) patients.45 poorly controlled (HbA1c=7-11%) T2DM […]

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Evaluating the impact of AMPK activation, a target of metformin, on risk of cardiovascular diseases and cancer in the UK Biobank: a Mendelian randomisation study.

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Whether metformin reduces cardiovascular or cancer risk is unclear owing to concerns over immortal time bias and confounding in observational studies. This study evaluated the effect of AMP-activated protein kinase […]

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Factors Contributing to the Rising National Cost of Glucose-Lowering Medicines for Diabetes During 2005-2007 and 2015-2017.

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We examined changes in glucose-lowering medication spending and quantified the magnitude of factors that are contributing to these changes.Using the Medical Expenditure Panel Survey, we estimated the change in spending […]

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5-Year Estimated Glomerular Filtration Rate in Patients with Hypoparathyroidism Treated with and Without rhPTH(1-84).

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Chronic hypoparathyroidism (HypoPT) is conventionally managed with oral calcium and active vitamin D. Recombinant human parathyroid hormone (1-84) (rhPTH[1-84]) is a therapy targeting the pathophysiology of HypoPT by replacing parathyroid […]

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Detection of Diabetes Status and Type in Youth Using Electronic Health Records: The SEARCH for Diabetes in Youth Study.

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Diabetes surveillance often requires manual medical chart reviews to confirm status and type. This project aimed to create an electronic health record (EHR)-based procedure for improving surveillance efficiency through automation […]

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Phase 3 trial of a small volume subcutaneous 6-month duration leuprolide acetate treatment for central precocious puberty.

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Gonadotropin releasing hormone agonists (GnRHa) are standard of care for central precocious puberty (CPP). A 6-month subcutaneous injection has recently been approved by Food and Drug Administration.Determine efficacy, pharmacokinetics and […]

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Impaired Succinate Response to a Mixed Meal in Obesity and Type 2 Diabetes Is Normalized After Metabolic Surgery.

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To explore the meal response of circulating succinate in patients with obesity and type 2 diabetes undergoing bariatric surgery and to examine the role of gastrointestinal glucose sensing in succinate […]

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Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy.

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Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent advances, our understanding of its pathophysiology remains incomplete. The aim of […]

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A single-blind, randomised, crossover study to reduce hypoglycaemia risk during postprandial exercise with closed-loop insulin delivery in adults with type 1 diabetes: announced (with or without bolus reduction) vs unannounced exercise strategies.

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For individuals living with type 1 diabetes, closed-loop insulin delivery improves glycaemic control. Nonetheless, maintenance of glycaemic control during exercise while a prandial insulin bolus remains active is a challenge […]

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Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy.

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Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent advances, our understanding of its pathophysiology remains incomplete. The aim of […]

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A personalised screening strategy for diabetic retinopathy: a cost-effectiveness perspective.

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In this study we examined the cost-effectiveness of three different screening strategies for diabetic retinopathy: using a personalised adaptive model, annual screening (fixed intervals), and the current Dutch guideline (stratified […]

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In Amateur Athletes With Type 1 Diabetes, a 9-Day Period of Cycling at Moderate-to-Vigorous Intensity Unexpectedly Increased the Time Spent in a State of Hyperglycemia, Which Was Associated With Impairment in Heart Rate Variability.

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In type 1 diabetes, autonomic dysfunction may occur early as a decrease in heart rate variability (HRV). In populations without diabetes, the positive effects of exercise training on HRV are […]

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The Effect of a Novel Low-Volume Aerobic Exercise Intervention on Liver Fat in Type 2 Diabetes: A Randomized Controlled Trial.

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The aim of this study was to examine the effect of a novel low-volume high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), or placebo (PLA) intervention on liver fat, glycemia, […]

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Age moderates the associations between TRAbs, free T3, and outcomes of Graves’s disease patients with radioactive iodine treatment.

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This study aimed to explore whether age moderates the associations between TSH-receptor antibodies (TRAbs) with thyroid hormones and remission in patients with Graves’ disease (GD) who undergo radioactive iodine (RAI) […]

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Association Between Fasting Glucose Variability in Young Adulthood and the Progression of Coronary Artery Calcification in Middle Age.

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To investigate whether intraindividual variability of fasting glucose (FG) in young adulthood is associated with coronary artery calcification (CAC) progression in middle age.We included 2,256 CARDIA (Coronary Artery Risk Development […]

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