Targeted next-generation sequencing for congenital hypothyroidism with positive neonatal TSH screening.

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Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder, however, its molecular etiology remains poorly understood.We performed genetic analysis of 24 causative genes using next-generation sequencing in 167 CH […]

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EV PD-L1 is correlated with clinical features and contributes to T cell suppression in pediatric thyroid cancer.

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The contribution of blood extracellular vesicular (EV) programmed death-ligand 1 (PD-L1) and programmed death-1 (PD-1) in papillary thyroid cancer (PTC) is uncertain.We sought to determine the relationship of EV PD-L1/PD-1 […]

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Non-thyroidal illness syndrome and hypothyroidism in ischemic heart disease population: Systematic review and meta-analysis.

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The association of non-thyroidal illness syndrome (NTIS) and hypothyroidism with the prognosis in ischemic heart disease (IHD) population is inconclusive.We aimed to evaluate the influence of NTIS and hypothyroidism on […]

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GIP as a therapeutic target in diabetes and obesity: insight from incretin co-agonists.

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The two hormones responsible for the amplification of insulin secretion after oral as opposed to intravenous nutrient administration are the gut peptides, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). […]

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Thyroglobulin changes are highly dependent on TSH in low-risk DTC patients not treated with 131I.

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Low risk Differentiated Thyroid Cancer (DTC) are currently rarely treated with radioiodine (131I) to ablate the postoperative remnant. Therefore, the interpretation of the serum thyroglobulin (Tg) values, should be reconsidered. […]

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Expression of SOAT1 in adrenocortical carcinoma and response to mitotane monotherapy: an ENSAT multicenter study.

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Objective response rate to mitotane in advanced adrenocortical carcinoma (ACC) is approximately 20% and adverse drug effects are frequent. To date there is no marker established that predicts treatment response. […]

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Development and validation of criteria for sparing confirmatory tests in diagnosing primary aldosteronism.

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The Endocrine Society Guidelines for the diagnosis of primary aldosteronism (PA) suggest that confirmatory tests (CFT) are not required when the following criteria are met: plasma aldosterone concentration (PAC) is […]

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Sustained remission of Lynch syndrome-associated metastatic adrenocortical carcinoma following checkpoint inhibitor therapy-associated multiorgan autoimmunity.

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Adrenocortical carcinoma (ACC) is a rare and aggressive tumour with limited treatment options for metastatic disease1 . Immunotherapy with checkpoint inhibition, in particular anti-programmed death receptor 1 (PD-1)/programmed death-ligand-1 (PD-L1) […]

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Health Care Costs Associated With Macrovascular, Microvascular, and Metabolic Complications of Type 2 Diabetes Across Time: Estimates From a Population-Based Cohort of More Than 0.8 Million Individuals With Up to 15 Years of Follow-up.

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Developing country-specific unit-cost catalogs is a key area for advancing economic research to improve medical and policy decisions. However, little is known about how health care costs vary by type […]

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Effects of Linagliptin on Cardiovascular and Kidney Outcomes in People With Normal and Reduced Kidney Function: Secondary Analysis of the CARMELINA Randomized Trial.

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Type 2 diabetes is a leading cause of kidney failure, but few outcome trials proactively enrolled individuals with chronic kidney disease (CKD). We performed secondary analyses of cardiovascular (CV) and […]

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SCREENING FOR androgen excess IN WOMEN: accuracy of self-reported excess body hair growth and menstrual dysfunction.

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Epidemiologic studies of polycystic ovary syndrome (PCOS) are limited, especially in populations where diagnostic resources are less available. In these setting, an accurate, low-cost screening tool would be invaluable.To test […]

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