ADMINISTRATION OF VALPROIC ACID IN CLINICALLY APPROVED DOSE IMPROVES NEUROLOGIC RECOVERY AND DECREASES BRAIN LESION SIZE IN SWINE SUBJECTED TO HEMORRHAGIC SHOCK AND TRAUMATIC BRAIN INJURY.

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Traumatic brain injury (TBI) and hemorrhage remain the leading causes of death after trauma. We have previously shown that a dose of Valproic Acid (VPA) at (150 mg/kg) can decrease […]

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EVALUATION OF THE EFFICACY OF COMMERCIAL AND NON-COMMERCIAL TOURNIQUETS FOR EXTREMITY HEMORRHAGE CONTROL IN A PERFUSED CADAVER MODEL.

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Tourniquets are a critical tool in the immediate response to life-threatening extremity hemorrhage, however, the optimal tourniquet type and effectiveness of non-commercial devices remain unclear. Our aim was to evaluate […]

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Current challenges in military trauma readiness: Insufficient relevant surgical case volumes in military treatment facilities.

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The management of battlefield trauma requires a specific skill set, which is optimized by regular trauma experience. As military casualties from the prolonged conflicts in the Middle East decrease, challenges […]

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Impact of uric acid on liver injury and intestinal permeability following resuscitated hemorrhagic shock in rats.

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Multiorgan failure is a consequence of severe ischemia-reperfusion injury after traumatic hemorrhagic shock (HS), a major cause of mortality in trauma patients. Circulating uric acid (UA), released from cell lysis, […]

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Downstream hospital system effects of a comprehensive trauma recovery services program.

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Trauma patients are often noted to have poor compliance but high recidivism and readmission rates. Participation in a trauma recovery services (TRS) program, which provides peer support and other psychosocial […]

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Evaluating the Association between AAST Emergency General Surgery Anatomic Severity Grades and Clinical Outcomes Using National Claims Data.

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Emergency General Surgery (EGS) encompasses a heterogenous population of acutely ill patients, and standardized methods for determining disease severity are essential for comparative effectiveness research and quality improvement initiatives. The […]

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DISTINCT IMMUNOLOGIC ENDOTYPES ARE ASSOCIATED WITH CLINICAL TRAJECTORY AFTER SEVERE BLUNT TRAUMA AND HEMORRHAGIC SHOCK.

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The genomic/cytokine “storm” after severe trauma is well described. However, the differing composition, magnitude and resolution of this response, and its relationship to clinical outcomes remains unclear.This is a secondary […]

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The cases not seen: Patterns of emergency department visits and procedures in the era of COVID-19.

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Prior data suggest Emergency Department (ED) visits for many emergency conditions decreased during the initial COVID-19 surge. However, the pandemic’s impact on the wide range of conditions seen in EDs, […]

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Effect of Implementing the Out-of-Hospital Traumatic Brain Injury Treatment Guidelines: The Excellence in Prehospital Injury Care for Children Study (EPIC4Kids).

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We evaluate the effect of implementing the out-of-hospital pediatric traumatic brain injury guidelines on outcomes in children with major traumatic brain injury.The Excellence in Prehospital Injury Care for Children study […]

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UK healthcare staff experiences and perceptions of a mass casualty terrorist incident response: a mixed-methods study.

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System learning from major incidents is a crucial element of improving preparedness for response to any future incidents. Sharing good practice and limitations stimulates further actions to improve preparedness and […]

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Hybrid emergency room shows maximum effect on trauma resuscitation when used in patients with higher severity.

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The Hybrid emergency room (ER) system is a novel trauma workflow that uses angio-computed tomography (CT) equipment in a trauma resuscitation room. Although the Hybrid ER system decreases time to […]

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Prothrombin Time ratio can predict mortality in severe pediatric trauma: Study in a French trauma center level 1.

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Injury results in more deaths in children than all other causes combined, but there is little data regarding the association of early coagulopathy on outcomes in pediatric patients with traumatic […]

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Correlation of history and physical examination with imaging in traumatic near-shore aquatic head and spinal injury.

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It remains unclear whether clinicians can rely on specific symptoms and signs to detect or exclude serious head and spinal injury sustained during near-shore aquatic activities. Our study investigated patients’ […]

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Comparative efficacy of therapeutics for traumatic musculoskeletal pain in the emergency setting: A network meta-analysis.

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Musculoskeletal pain control is essential in the management of trauma patients in the emergency department (ED). Here, we performed a network meta-analysis of the use of analgesics to manage traumatic […]

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Feasibility and usefulness of rapid 2-channel-EEG-monitoring (point-of-care EEG) for acute CNS disorders in the paediatric emergency department: an observational study.

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The aim of this study was to determine the feasibility and clinical utility of point-of-care electroencephalogram (pocEEG) in the paediatric emergency department (ED) for children presenting with acute non-traumatic central […]

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Finding the Elusive Trauma Denominator: Feasibility of Combining Data Sets to Quantify the True Burden of Firearm Trauma.

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Evidence guiding firearm injury prevention is limited by current data collection infrastructure. Trauma registries (TR) omit pre-hospital deaths and underestimate the burden of injury. In contrast, the National Violent Death […]

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Early Dynamic Orchestration of Immunologic Mediators Identifies Multiply Injured Patients who are Tolerant or Sensitive to Hemorrhage.

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Multiply injured patients are at risk of complications including infections, acute and prolonged organ dysfunction. The immunologic response to injury has been shown to affect outcomes. Recent advances in computational […]

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ANTITHROMBIN-III AMELIORATES POST-TBI CEREBRAL LEUKOCYTE MOBILIZATION ENHANCING RECOVERY OF BLOOD BRAIN BARRIER INTEGRITY.

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Acute traumatic coagulopathy often accompanies traumatic brain injury (TBI) and may impair cognitive recovery. Antithrombin III (AT-III) reduces the hypercoagulability of TBI. AT-III and heparinoids such as enoxaparin (ENX) demonstrate […]

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Outcome after surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures and moderate to severe traumatic brain injury (CWIS-TBI).

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Outcomes after surgical stabilization of rib fractures (SSRF) have not been studied in patients with multiple rib fractures and traumatic brain injury (TBI). We hypothesized that SSRF, as compared to […]

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The swine as a vehicle for research in trauma induced coagulopathy: introducing Principal Component Analysis for viscoelastic coagulation tests.

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Uncontrolled bleeding is the leading cause of potentially preventable deaths among trauma patients. Tissue injury and shock result in trauma-induced coagulopathy (TIC). There are still uncertainties regarding detection methods and […]

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Do patients with minimal blunt thoracic aortic injury (BTAI) require TEVAR?

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The optimal management of “minimal” blunt thoracic aortic injuries (BTAI) remains controversial, with experienced centers employing therapy ranging from medical management (MM) to thoracic endovascular repair (TEVAR).The Aortic Trauma Foundation […]

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