ADMINISTRATION OF VALPROIC ACID IN CLINICALLY APPROVED DOSE IMPROVES NEUROLOGIC RECOVERY AND DECREASES BRAIN LESION SIZE IN SWINE SUBJECTED TO HEMORRHAGIC SHOCK AND TRAUMATIC BRAIN INJURY.

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Traumatic brain injury (TBI) and hemorrhage remain the leading causes of death after trauma. We have previously shown that a dose of Valproic Acid (VPA) at (150 mg/kg) can decrease […]

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EVALUATION OF THE EFFICACY OF COMMERCIAL AND NON-COMMERCIAL TOURNIQUETS FOR EXTREMITY HEMORRHAGE CONTROL IN A PERFUSED CADAVER MODEL.

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Tourniquets are a critical tool in the immediate response to life-threatening extremity hemorrhage, however, the optimal tourniquet type and effectiveness of non-commercial devices remain unclear. Our aim was to evaluate […]

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Current challenges in military trauma readiness: Insufficient relevant surgical case volumes in military treatment facilities.

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The management of battlefield trauma requires a specific skill set, which is optimized by regular trauma experience. As military casualties from the prolonged conflicts in the Middle East decrease, challenges […]

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Impact of uric acid on liver injury and intestinal permeability following resuscitated hemorrhagic shock in rats.

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Multiorgan failure is a consequence of severe ischemia-reperfusion injury after traumatic hemorrhagic shock (HS), a major cause of mortality in trauma patients. Circulating uric acid (UA), released from cell lysis, […]

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Downstream hospital system effects of a comprehensive trauma recovery services program.

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Trauma patients are often noted to have poor compliance but high recidivism and readmission rates. Participation in a trauma recovery services (TRS) program, which provides peer support and other psychosocial […]

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Duration of symptoms is the only predictor of testicular salvage following testicular torsion in children: A case-control study.

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Testicular torsion (TT) is an emergency requiring a prompt diagnosis and surgery to avoid irreversible changes and a complete loss of testis. The present study aimed to identify potential factors […]

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Bacteriology of pediatric breast abscesses beyond the neonatal period.

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Limited data exist regarding the presentation and bacteriology of nonneonatal pediatric breast abscess.To determine the bacteriology and characteristic presentation of pediatric breast abscesses in a tertiary care center.Cross-sectional study of […]

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Evaluating the Association between AAST Emergency General Surgery Anatomic Severity Grades and Clinical Outcomes Using National Claims Data.

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Emergency General Surgery (EGS) encompasses a heterogenous population of acutely ill patients, and standardized methods for determining disease severity are essential for comparative effectiveness research and quality improvement initiatives. The […]

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DISTINCT IMMUNOLOGIC ENDOTYPES ARE ASSOCIATED WITH CLINICAL TRAJECTORY AFTER SEVERE BLUNT TRAUMA AND HEMORRHAGIC SHOCK.

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The genomic/cytokine “storm” after severe trauma is well described. However, the differing composition, magnitude and resolution of this response, and its relationship to clinical outcomes remains unclear.This is a secondary […]

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Development and verification of a predictive nomogram to evaluate the risk of complicating ventricular tachyarrhythmia after acute myocardial infarction during hospitalization: A retrospective analysis.

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The purpose of this study was to establish a nomogram to predict the risk of complicating ventricular tachyarrhythmia (VTA) in patients with acute myocardial infarction (AMI) during hospitalization and to […]

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Therapeutical plasma exchange for thrombotic thrombocytopenic purpura in the emergency department: A single center experience.

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Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening and easily misdiagnosed thrombotic microangiopathy disease. Few studies have reported the use of therapeutic plasma exchange (TPE) for TTP in emergency departments […]

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Supporting children and adolescents following parental bereavement: guidance for health-care professionals.

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Death of a parent in childhood and adolescence is a distressing life event. Childhood grief reactions are distinct from those in adults, and are affected by developmental and contextual factors […]

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Characteristics of frequent paediatric users of emergency departments in England: an observational study using routine national data.

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Frequent attendances of the same users in emergency departments (ED) can intensify workload pressures and are common among children, yet little is known about the characteristics of paediatric frequent users […]

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Effect of an Emergency Department Care Bundle on 30-Day Hospital Discharge and Survival Among Elderly Patients With Acute Heart Failure: The ELISABETH Randomized Clinical Trial.

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Clinical guidelines for the early management of acute heart failure in the emergency department (ED) setting are based on only moderate levels of evidence, with subsequent low adherence to these […]

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Improving Quality of Care Through a Mandatory Provincial Audit Program: Ontario’s Emergency Department Return Visit Quality Program.

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The Emergency Department Return Visit Quality Program was launched in Ontario, Canada, to promote a culture of quality. It mandates the province’s largest-volume emergency departments (EDs) to audit charts of […]

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Is the COVID-19 pandemic even darker for some? Examining dark personality and affective, cognitive, and behavioral responses to the COVID-19 pandemic.

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As the COVID-19 pandemic and interventions intended to minimize its spread continue to impact daily life, personality research may help to address the different ways in which people respond to […]

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Encephalopathy in COVID-19 Presenting With Acute Aphasia Mimicking Stroke.

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Introduction: Neurological manifestations are emerging as relatively frequent complications of corona virus disease 2019 (COVID-19), including stroke and encephalopathy. Clinical characteristics of the latter are heterogeneous and not yet fully […]

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Therapeutic experience of an 89-year-old high-risk patient with incarcerated cholecystolithiasis: A case report and literature review.

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The global pandemic of coronavirus disease 2019 pneumonia poses a particular challenge to the emergency surgical treatment of elderly patients with high-risk acute abdominal diseases. Elderly patients are a high-risk […]

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A look at the global impact of SARS CoV-2 on orthopedic services.

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The COVID-19 pandemic profoundly impacted healthcare institutions worldwide. Particularly, orthopedic departments had to adapt their operational models.This review aimed to quantify the reduction in surgical and outpatient caseloads, identify other […]

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Immunoinformatic Analysis of SARS-CoV-2 Nucleocapsid Protein and Identification of COVID-19 Vaccine Targets.

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COVID-19 is a worldwide emergency; therefore, there is a critical need for foundational knowledge about B and T cell responses to SARS-CoV-2 essential for vaccine development. However, little information is […]

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Difficult intravenous access in the emergency department: Performance and impact of ultrasound-guided IV insertion performed by nurses.

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Difficult intravenous access (DIVA) is a common problem in Emergency Departments (EDs), yet the prevalence and clinical impact of this condition is poorly understood. Ultrasound-guided peripheral intravenous catheter (USGPIV) insertion […]

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Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial.

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Among patients with out-of-hospital cardiac arrest (OHCA) and ventricular fibrillation, more than half present with refractory ventricular fibrillation unresponsive to initial standard advanced cardiac life support (ACLS) treatment. We did […]

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A Systematic Review and Provisional Metanalysis on Psychopathologic Burden on Health Care Workers of Coronavirus Outbreaks.

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The new coronavirus (SARS-CoV-2) shows several similarities with previous outbreaks of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Aim of this systematic review and meta-analysis is […]

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The Emergency Response Capacity of Plant-Based Biopharmaceutical Manufacturing-What It Is and What It Could Be.

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Several epidemic and pandemic diseases have emerged over the last 20 years with increasing reach and severity. The current COVID-19 pandemic has affected most of the world’s population, causing millions […]

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Association of air temperature with pediatric intussusception in northeastern China: A 10-year retrospective study.

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The aim of this study was to determine whether an association existed between intussusception and air temperature.A retrospective study was performed between March 2006 and February 2016 to determine the […]

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The Effect of Cognitive Behavioral Therapy on Depression, Anxiety, and Stress in Patients With COVID-19: A Randomized Controlled Trial.

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Background: As a public health emergency of international concern, the COVID-19 outbreak has had a tremendous impact on patients’ psychological health. However, studies on psychological interventions in patients with COVID-19 […]

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