Long non-coding RNA MALAT1 suppresses miR-211 to confer protection from UV-mediated DNA damage in vitiligo epidermis by upregulating SIRT1.

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The absence of melanocytes poses a challenge for long-term tissue homeostasis in vitiligo. Surprisingly, while individuals with Fitzpatrick phototypes I-II (low melanin content) have a higher incidence of melanoma and […]

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Gamma knife radiosurgery for uveal melanomas and metastases: a systematic review and meta-analysis.

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Gamma knife radiosurgery is regarded as the gold-standard stereotactic radiosurgery modality for the treatment of intracranial tumours, and its use has been expanded for the treatment of intraocular malignancies. The […]

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Response to “Reduction in skin cancer diagnosis, and overall cancer referrals, during the COVID-19 pandemic”.

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we noted with interest the recent letter by Earnshaw and colleagues documenting decreased skin cancer referrals to their dermatology department and report a similar phenomenon seen in Ireland on a […]

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Intermittent schedules of the oral RAF-MEK inhibitor CH5126766/VS-6766 in patients with RAS/RAF-mutant solid tumours and multiple myeloma: a single-centre, open-label, phase 1 dose-escalation and basket dose-expansion study.

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CH5126766 (also known as VS-6766, and previously named RO5126766), a novel MEK-pan-RAF inhibitor, has shown antitumour activity across various solid tumours; however, its initial development was limited by toxicity. We […]

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Incomplete surgical excision of keratinocyte skin cancers: a systematic review and meta-analysis.

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Keratinocyte or non-melanoma skin cancer (NMSC) is the commonest malignancy worldwide. Usual treatment is surgical excision. Current guidelines underestimate incomplete excision rates.We aimed to determine the risk of incomplete excision […]

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Nivolumab and Ipilimumab in Metastatic Uveal Melanoma: Results From a Single-Arm Phase II Study.

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Metastatic uveal melanoma has poor overall survival (OS) and no approved systemic therapy options. Studies of single-agent immunotherapy regimens have shown minimal benefit. There is the potential for improved responses […]

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“Fake news” in dermatology. Results from an observational, cross-sectional study.

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Social networks have become a means for disseminating information on health-related matters.Describe the characteristics and analyze the accuracy of the dermatology content that is most often shared on the most […]

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Amelanotic melanoma of the head and neck: analysis of tumor characteristics from the National Cancer Database.

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Amelanotic melanoma is an extremely rare subtype of cutaneous melanoma. The tumor characteristics are still not well understood, especially for those located in the head and neck.Tumor characteristics of patients […]

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Occupation and cutaneous melanoma: a 45-year historical cohort study of 14·9 million people in five Nordic countries.

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The age-adjusted incidence of cutaneous melanoma (CM) in the Nordic countries has increased during the last 60 years. Few prospective population-based studies have estimated the occupational variation in CM risk over […]

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Cutaneous toxicities in melanoma patients receiving checkpoint inhibitor therapy, a retrospective review: The experience of a single large specialist institution.

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CPI was approved by the European Medicines Agency (EMA) in 2012 for advanced melanoma and extended to include adjuvant melanoma treatment in 2018. Expectation for survival in advanced melanoma now […]

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Five-Year Outcomes With Nivolumab in Patients With Wild-Type BRAF Advanced Melanoma.

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The CheckMate 066 trial investigated nivolumab monotherapy as first-line treatment for patients with previously untreated BRAF wild-type advanced melanoma. Five-year results are presented herein.In this multicenter, double-blind, phase III study, […]

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Children of the Sun: a historical look at how pediatric light therapy shaped attitudes and behaviors toward sunbathing.

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Today, parents are warned to protect their children from the sun’s ultraviolet (UV) rays, the most preventable and leading cause of skin cancer. Yet, during the first half of the […]

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Adjuvant nivolumab versus ipilimumab in resected stage IIIB-C and stage IV melanoma (CheckMate 238): 4-year results from a multicentre, double-blind, randomised, controlled, phase 3 trial.

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Previously, findings from CheckMate 238, a double-blind, phase 3 adjuvant trial in patients with resected stage IIIB-C or stage IV melanoma, showed significant improvements in recurrence-free survival and distant metastasis-free […]

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Longer Follow-Up Confirms Recurrence-Free Survival Benefit of Adjuvant Pembrolizumab in High-Risk Stage III Melanoma: Updated Results From the EORTC 1325-MG/KEYNOTE-054 Trial.

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We conducted the phase III double-blind European Organisation for Research and Treatment of Cancer (EORTC) 1325/KEYNOTE-054 trial to evaluate pembrolizumab versus placebo in patients with resected high-risk stage III melanoma. […]

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Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient.

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Conventional wisdom has rendered patients with brain metastases ineligible for clinical trials for fear that poor survival could mask the benefit of otherwise promising treatments. Our group previously published the […]

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The Epidemiology of Malignant Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma in the United Kingdom from 2004-2014: A Population-Based Cohort Analysis using the Clinical Practice Research Datalink.

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Skin cancers, including malignant melanoma and keratinocyte skin cancers, are the most common malignancy in the United Kingdom (UK), and global incidence is increasing rapidly1 . While malignant melanoma (MM) […]

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The Epidemiology of Malignant Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma in the United Kingdom from 2004-2014: A Population-Based Cohort Analysis using the Clinical Practice Research Datalink.

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Skin cancers, including malignant melanoma and keratinocyte skin cancers, are the most common malignancy in the United Kingdom (UK), and global incidence is increasing rapidly1 . While malignant melanoma (MM) […]

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Review of smartphone mobile applications for skin cancer detection: what are the changes in availability, functionality, and costs to users over time?

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Smartphone applications (apps) are available to consumers for skin cancer prevention and early detection. This study aims to review changes over time in the skin cancer apps available to consumers […]

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Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma.

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In the previously reported primary analysis of this phase 3 trial, 12 months of adjuvant dabrafenib plus trametinib resulted in significantly longer relapse-free survival than placebo in patients with resected […]

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The ongoing racial disparities in melanoma: an analysis of the Surveillance, Epidemiology, and End Results database (SEER) database (1975-2016).

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Although the majority of cutaneous melanoma patients are non-Hispanic white (NHW), minorities consistently suffer worse melanoma specific survival (MSS). Much of the literature comes from analyses of registries from the […]

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Reproductive factors, hormone use and melanoma risk: an Australian prospective cohort study.

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Despite many epidemiologic studies in the past two decades investigating whether hormonal and reproductive factors increase risk of melanoma, the issue remains unresolved.1 Findings appear to differ according to study […]

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Reproductive factors, hormone use and melanoma risk: an Australian prospective cohort study.

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Despite many epidemiologic studies in the past two decades investigating whether hormonal and reproductive factors increase risk of melanoma, the issue remains unresolved.1 Findings appear to differ according to study […]

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Validation of a Clinicopathological and Gene Expression Profile (CP-GEP) model for sentinel lymph node metastasis in primary cutaneous melanoma.

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The Clinicopathological and Gene Expression Profile (CP-GEP) model was developed to accurately identify patients with T1-T3 primary cutaneous melanoma at low risk for nodal metastasis.To validate the CP-GEP model in […]

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In vivo imaging characterization of basal cell carcinoma cutaneous response to high dose ionizing radiation therapy: A prospective study of reflectance confocal microscopy, dermoscopy, and ultrasound.

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Radiation therapy (RT) is a treatment option for selected skin cancers. The histologic effects of RT on normal skin or skin cancers are not well-characterized. Dermoscopy, high frequency ultrasonography (HFUS), […]

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