Neoadjuvant dabrafenib combined with trametinib for resectable, stage IIIB-C, BRAFV600 mutation-positive melanoma (NeoCombi): a single-arm, open-label, single-centre, phase 2 trial.

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Abstract: Adjuvant dabrafenib plus trametinib therapy improves relapse-free survival in patients with resected stage III melanoma. We aimed to ascertain the proportion of patients who would have a pathological response […]

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Insomnia and other sleep complaints in inflammatory versus noninflammatory skin disorders: An observational case-control study.

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Abstract: Sleep problems are common in patients with dermatologic disorders. However, it is unknown whether inflammatory skin disorders are associated with more sleep problems than noninflammatory skin disorders.To determine whether […]

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Factors Associated with Time to Surgery in Melanoma: An Analysis of the National Cancer Database.

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Abstract: Timely treatment for melanoma may affect survival and characterizing predictors of delay may inform intervention strategies.To determine characteristics associated with surgical interval in melanoma.The National Cancer Database was used […]

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Diagnostic accuracy of imaging studies for initial staging of T2b-T4b melanoma patients. A cross-sectional study.

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Abstract: There is no consensus on the imaging tests that should be performed at the initial staging of melanoma patients.Evaluate the diagnostic accuracy of four imaging studies for the initial […]

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Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial.

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Abstract: The outcome of patients with macroscopic stage III melanoma is poor. Neoadjuvant treatment with ipilimumab plus nivolumab at the standard dosing schedule induced pathological responses in a high proportion […]

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Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma.

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Abstract: Patients who have unresectable or metastatic melanoma with a BRAF V600E or V600K mutation have prolonged progression-free survival and overall survival when receiving treatment with BRAF inhibitors plus MEK […]

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Use of antiepileptic drugs and risk of skin cancer: A nationwide case-control study.

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Abstract: Several antiepileptic drugs are photosensitizing; however, it is not known whether this confers an increased risk of skin cancer.To examine the association between common antiepileptic drugs and basal cell […]

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Meta-Analysis in Metastatic Uveal Melanoma to Determine Progression-Free and Overall Survival Benchmarks: an International Rare Cancers Initiative (IRCI) Ocular Melanoma study.

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Abstract: Despite the completion of numerous phase II studies, a standard of care treatment has yet to be defined for metastatic uveal melanoma (mUM). To determine benchmarks of progression free […]

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Talimogene laherparepvec (T-VEC) in advanced melanoma: complete response in a heart and kidney transplant patient. A case report.

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Talimogene laherparepvec (T-VEC) is a intralesional oncolytic virotherapy, licensed in the European Union for locoregional advanced melanoma of American Joint Committee on Cancer stages IIIB, IIIC and IVM1a. Organ transplant […]

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Talimogene laherparepvec (T-VEC) in advanced melanoma: complete response in a heart and kidney transplant patient. A case report.

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Talimogene laherparepvec (T-VEC) is a intralesional oncolytic virotherapy, licensed in the European Union for locoregional advanced melanoma of American Joint Committee on Cancer stages IIIB, IIIC and IVM1a. Organ transplant […]

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Micrographic controlled surgery of basal cell carcinomas – Rapid Lump Examination (RLE) in comparison to H&E-stained paraffin sections.

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The most common skin cancer is basal cell carcinoma (BCC). As the incidence of BCC is increasing, it is of major interest to optimize diagnostic and therapeutic options. The most […]

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