Longer Follow-Up Confirms Recurrence-Free Survival Benefit of Adjuvant Pembrolizumab in High-Risk Stage III Melanoma: Updated Results From the EORTC 1325-MG/KEYNOTE-054 Trial.

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We conducted the phase III double-blind European Organisation for Research and Treatment of Cancer (EORTC) 1325/KEYNOTE-054 trial to evaluate pembrolizumab versus placebo in patients with resected high-risk stage III melanoma. […]

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Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient.

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Conventional wisdom has rendered patients with brain metastases ineligible for clinical trials for fear that poor survival could mask the benefit of otherwise promising treatments. Our group previously published the […]

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The Epidemiology of Malignant Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma in the United Kingdom from 2004-2014: A Population-Based Cohort Analysis using the Clinical Practice Research Datalink.

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Skin cancers, including malignant melanoma and keratinocyte skin cancers, are the most common malignancy in the United Kingdom (UK), and global incidence is increasing rapidly1 . While malignant melanoma (MM) […]

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The Epidemiology of Malignant Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma in the United Kingdom from 2004-2014: A Population-Based Cohort Analysis using the Clinical Practice Research Datalink.

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Skin cancers, including malignant melanoma and keratinocyte skin cancers, are the most common malignancy in the United Kingdom (UK), and global incidence is increasing rapidly1 . While malignant melanoma (MM) […]

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Review of smartphone mobile applications for skin cancer detection: what are the changes in availability, functionality, and costs to users over time?

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Smartphone applications (apps) are available to consumers for skin cancer prevention and early detection. This study aims to review changes over time in the skin cancer apps available to consumers […]

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The ongoing racial disparities in melanoma: an analysis of the Surveillance, Epidemiology, and End Results database (SEER) database (1975-2016).

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Although the majority of cutaneous melanoma patients are non-Hispanic white (NHW), minorities consistently suffer worse melanoma specific survival (MSS). Much of the literature comes from analyses of registries from the […]

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Reproductive factors, hormone use and melanoma risk: an Australian prospective cohort study.

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Despite many epidemiologic studies in the past two decades investigating whether hormonal and reproductive factors increase risk of melanoma, the issue remains unresolved.1 Findings appear to differ according to study […]

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Reproductive factors, hormone use and melanoma risk: an Australian prospective cohort study.

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Despite many epidemiologic studies in the past two decades investigating whether hormonal and reproductive factors increase risk of melanoma, the issue remains unresolved.1 Findings appear to differ according to study […]

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Validation of a Clinicopathological and Gene Expression Profile (CP-GEP) model for sentinel lymph node metastasis in primary cutaneous melanoma.

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The Clinicopathological and Gene Expression Profile (CP-GEP) model was developed to accurately identify patients with T1-T3 primary cutaneous melanoma at low risk for nodal metastasis.To validate the CP-GEP model in […]

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In vivo imaging characterization of basal cell carcinoma cutaneous response to high dose ionizing radiation therapy: A prospective study of reflectance confocal microscopy, dermoscopy, and ultrasound.

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Radiation therapy (RT) is a treatment option for selected skin cancers. The histologic effects of RT on normal skin or skin cancers are not well-characterized. Dermoscopy, high frequency ultrasonography (HFUS), […]

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Cutaneous T-cell lymphoma is associated with increased risk of lymphoma, melanoma, lung cancer, and bladder cancer: a systematic review and meta-analysis.

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Patients with cutaneous T-cell lymphoma (CTCL) are at a higher risk of developing second malignancies. However, rates of incidence vary significantly across studies.A systematic review and meta-analysis of manuscripts published […]

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The Impact of Demographics, Socioeconomics, and Healthcare Access on Melanoma Outcomes.

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Disparities in melanoma care exist in the United States. Disparities in provider type, patient demographics, place of residence, insurance status, socioeconomic status (SES), race/ethnicity and age impact melanoma outcomes. Melanomas […]

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Long-term outcomes of Mohs micrographic surgery for invasive melanoma of the trunk and proximal extremities.

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Microscopic evaluation of the entire surgical margin during excision of cutaneous malignancies results in the highest rates of complete excision and lowest rates of true local scar recurrence. Few studies […]

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β3 integrin immunohistochemistry as a method to predict sentinel lymph node status in patients with primary cutaneous melanoma.

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Integrins are heterodimeric proteins composed of noncovalently linked ɑ and β subunits which are essential for a wide range of normal physiology and also play prominent roles in cancer. Here […]

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Dabrafenib and Trametinib in Patients With Tumors With BRAFV600E Mutations: Results of the NCI-MATCH Trial Subprotocol H.

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BRAFV600 mutations are commonly found in melanoma and thyroid cancers and to a lesser degree in other tumor types. Subprotocol H (EAY131-H) of the NCI-MATCH platform trial sought to investigate […]

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Histopathological features of complete pathological response predict recurrence-free survival following neoadjuvant targeted therapy for metastatic melanoma.

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Recent clinical trials demonstrated safety and efficacy of neoadjuvant dabrafenib and trametinib (DT) among patients with surgically resectable clinical stage III BRAFV600E/K mutant melanoma. Although patients achieving a complete pathological […]

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Dark pigmented lesions: diagnostic accuracy of dermatoscopy and reflectance confocal microscopy in a tertiary referral center for skin cancer diagnosis.

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There is lack of studies on the diagnostic accuracy of dermatoscopy and reflectance confocal microscopy (RCM) for dark pigmented lesions.To assess the diagnostic accuracy of dermatoscopy plus confocal microscopy for […]

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Clinicopathological and dermoscopic features of amelanotic and hypomelanotic melanoma: a retrospective multicentric study.

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Amelanotic and hypomelanotic melanoma (AHM) has a higher risk of delayed diagnosis and a significant lower 5-year melanoma-specific survival compared to pigmented melanoma. Our aim was the evaluation of the […]

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Clinicoprognostic characteristics of cutaneous metastatic melanoma: a retrospective comparative study between acral and nonacral melanoma.

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Although cutaneous melanoma has been widely evaluated, data elucidating the clinical features and prognostic factors of cutaneous metastatic melanoma are limited.To determine and compare the clinicoprognostic features of cutaneous metastasis […]

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Dermatological and epidemiological profile of patients with albinism in Togo in 2019: results of two consultation campaigns.

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People with albinism (PWA) are targets of prejudice and social exclusion and have limited access to specialized medical care and resources. Our study aimed to describe the epidemiological and dermatological […]

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Clinical Benefit of Baseline Imaging in Merkel Cell Carcinoma: Analysis of 584 Patients.

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Merkel cell carcinoma (MCC) guidelines derive from melanoma and do not recommend baseline cross-sectional imaging for most patients. However, MCC is more likely to have metastasized at diagnosis than melanoma.To […]

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Delineation of clinical and biological factors associated with cutaneous squamous cell carcinoma amongst chronic lymphocytic leukemia patients.

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The incidence of cutaneous squamous cell carcinoma (SCC) in chronic lymphocytic leukemia (CLL) patients is significantly higher compared to age- and sex- matched controls.To evaluate the association of factors associated […]

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Significance of SOX18 expression in nonmelanoma skin cancers for prediction of high-risk patients: a preliminary study.

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SOX18 is an integral transcription factor that is involved in endothelial cells differentiation during both angiogenesis and lymphangiogenesis. Therefore, it has been implicated in tumor progression and metastasis.To study SOX18 […]

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Reporting regression in primary cutaneous melanoma. Part 2: prognosis, evaluation and management.

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The effect of histological regression on patient prognosis for primary cutaneous melanoma is controversial. Some authors hypothesize that regression indicates a robust systemic immune response and may decrease risk of […]

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Melanoma diagnosed on digital dermoscopy monitoring: a side-by-side image comparison is needed to improve early detection.

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Digital dermoscopy monitoring (DDM) helps to recognize melanomas lacking specific dermoscopic features at baseline, but the number of melanomas eventually developing specific features is still unknown.To assess how many melanomas […]

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Targeted and immunotherapies in BRAF mutant melanoma – where we are standing and what to expect.

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The therapeutic landscape for melanoma evolved drastically in the past decade. Currently, immune checkpoint inhibitors and small molecule inhibitors targeting the MAPK pathway are the two mainstay therapies for BRAF […]

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