Measurement properties of the Rajka-Langeland severity score in children and adults with atopic dermatitis.

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Multiple atopic dermatitis (AD) severity scales exist, with no gold-standard for use in clinical practice.Determine the measurement properties of the Rajka-Langeland score and compare with other clinician-reported outcomes in adults […]

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Drug reaction with eosinophilia and systemic symptoms (DRESS) in the pediatric population: A systematic review of the literature.

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Drug reaction with eosinophilia and systemic symptoms (DRESS) is a drug-induced hypersensitivity reaction that can have fatal complications. While substantial data exists regarding DRESS in adults, a systematic review of […]

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No Evidence of Increased Cancer Incidence in Children Using Topical Tacrolimus for Atopic Dermatitis.

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Long-term safety of topical calcineurin inhibitors is not well understood. APPLES™ (A Prospective Pediatric Longitudinal Evaluation to Assess the Long-Term Safety of Tacrolimus Ointment for the Treatment of Atopic Dermatitis […]

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The prevalence and odds of anxiety and depression in children and adults with hidradenitis suppurativa: systematic review and meta-analyses.

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder. Previous studies have yielded divergent results on the prevalence of depression and anxiety in HS patients.The aim of this meta-analysis was […]

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Ustekinumab for the treatment of moderate-to-severe plaque psoriasis in pediatric patients (≥6 to <12 years of age): efficacy, safety, pharmacokinetic, and biomarker results from the open-label CADMUS Jr study.

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Limited options are available for treatment of pediatric psoriasis.To evaluate the efficacy and safety of ustekinumab in pediatric psoriasis patients (≥6 to <12 years of age).CADMUS Junior (Jr), a phase […]

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Serious infection risk in children with psoriasis on systemic treatment: a propensity score matched population-based study.

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Psoriasis (PsO) is increasingly treated with systemic medications, yet their safety is not well characterized in children.We sought to estimate the 6-month risk of serious infections in children with PsO […]

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Quality of Life, Emotion Dysregulation, Attention Deficit and Psychiatric Comorbidity in Children and Adolescent with Vitiligo.

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Vitiligo is an acquired pigmentation disorder. The aim of this study is to evaluate the quality of life and psychiatric comorbidity in pediatric patients with vitiligo.Thirty patients aged 8-18 years […]

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Association of metabolic syndrome with pediatric psoriasis: a case-control study in Kabul, Afghanistan.

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Limited studies have assessed the risk of metabolic syndrome in pediatric psoriasis. This study was aimed to investigate the association of obesity and metabolic syndrome with pediatric psoriasis in Afghanistan.A […]

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Topical calcineurin inhibitors for pediatric periorificial dermatitis.

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Data regarding the treatment of periorificial dermatitis (POD) with topical calcineurin inhibitors (TCI) in the pediatric population are limited.To assess the clinical utility of TCI in pediatric patients with POD.A […]

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Prenatal, infantile, and childhood tobacco exposure and risk of pediatric psoriasis in the Danish National Birth Cohort offspring.

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Tobacco smoking is implicated in psoriasis among adults.To determine whether prenatal, infantile, and childhood tobacco exposure increase risk of pediatric psoriasis.Data from Danish National Birth Cohort participants were collected at […]

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Product of Investigator Global Assessment and body surface area (IGAxBSA): a practice-friendly alternative to the Eczema Area and Severity Index (EASI) to assess atopic dermatitis severity in children.

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Accurately documenting pediatric atopic dermatitis (AD) severity is important, but research tools, such as Eczema Area and Severity Index (EASI), are too time-consuming for clinical settings. Product of the Physician […]

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Exploring the impact of paediatric localized scleroderma on health-related quality of life: Focus groups with youth and caregivers.

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Paediatric localized scleroderma (LS) can negatively impact health-related quality of life (HRQoL) by causing skin fibrosis, abnormal limb development, disfigurement, and side effects from immunosuppressive treatment. Studies to date have […]

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Dermoscopy of idiopathic facial aseptic granuloma: report of 2 cases.

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Idiopathic facial aseptic granuloma (IFAG) is an uncommon childhood condition, characterized by one or more asymptomatic erythematous-violaceous nodules, usually located on the cheeks and eyelid [1]. IFAG heals spontaneously usually […]

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Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.

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Pembrolizumab is approved for the treatment of advanced cancer in adults; however, no information is available on safety and efficacy in paediatric patients. We aimed to establish the recommended phase […]

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Early Life Exposure to Air Pollution and Incidence of Childhood Asthma, Allergic Rhinitis and Eczema.

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There is growing evidence that air pollution may contribute to the development of childhood asthma and other allergic diseases. In this follow-up of the Toronto Child Health Evaluation Questionnaire (T-CHEQ) […]

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Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP).

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Eczema control has been identified as an important outcome by key stakeholders in eczema research (including patients, carers, healthcare professionals, and researchers) but no validated instruments for the domain have […]

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Symptomatic mucosal involvement in pachyonychia congenita: the challenges in infants and young children.

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Pachyonychia congenita (PC) is a rare autosomal dominant genodermatosis caused by a mutation in any one of 5 keratin genes (KRT6A, KRT6B, KRT6C, KRT16 or KRT17) featuring painful palmoplantar keratoderma, […]

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