Dupilumab in adolescents with uncontrolled moderate-to-severe atopic dermatitis: results from a phase IIa open-label trial and subsequent phase III open-label extension.

Abstract: Dupilumab (monoclonal antibody inhibiting IL-4/IL-13 signalling) is approved for use in adolescents aged ? 12 years with inadequately controlled moderate-to-severe atopic dermatitis (AD). Dupilumab significantly improved AD signs/symptoms in […]

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TREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for a European safety study of dupilumab and other systemic therapies in patients with atopic eczema.

Abstract: A long-term prospective observational safety study is essential to fully characterize the safety profile of systemic immunomodulating therapies for patients with atopic eczema. The TREatment of ATopic eczema (TREAT) […]

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Allergic Diseases and Long Term Risk of Autoimmune Disorders: longitudinal cohort study and cluster analysis.

Abstract: The association between allergic diseases (ADs) and autoimmune disorders (AIDs) is not well established.To determine incidence rates of AIDs in allergic rhinitis/conjunctivitis (ARC), atopic eczema (AE) and asthma, and […]

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Influence of prenatal and early-life exposures on food allergy and eczema in infancy: a birth cohort study.

Few prospective birth cohort studies are available on the effects of prenatal and early-life exposures on food allergy and eczema among Chinese children. The aim of this study was to evaluate the influence of prenatal and early-life exposures on food allergy and eczema during the first year of life in a prospective birth cohort study.This study was based on a prospective, observational birth cohort of 976 mother-child pairs in three Streets in Changsha, China from January to December 2015. Data on prenatal, early-life exposures and allergic outcomes were obtained from questionnaires collected at birth, and 1, 3, 6, 8, and 12?months of age. Multivariate logistic regression models were performed to estimate the effects of prenatal and early-life exposures on food allergy and eczema.Common risk factors for food allergy and eczema in infancy were parental history of allergy, while moderate eggs consumption (3-4 times/week) during pregnancy was protective for both of them compared with low consumption (? 2 times/week). Factors only associated with food allergy were maternal aquatic products consumption during pregnancy, number of older siblings and age of solid food introduction, whereas factors only associated with eczema were maternal milk or milk products consumption during pregnancy, maternal antibiotic exposure during pregnancy, season of birth and antibiotic exposure through medication during the first year of life.Our study suggests that factors associated with food allergy and eczema are multifaceted, which involving hereditary, environmental and nutritional exposures. Furthermore, differential factors influence the development of food allergy and eczema in infants.

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Natural Language Processing of Reddit Data to Evaluate Dermatology Patient Experiences and Therapeutics.

There is a lack of research studying patient-generated data on Reddit, one of the world’s most popular forums with active users interested in dermatology. Techniques within natural language processing, a field of artificial intelligence, can analyze large amounts of text information and extract insights.To apply natural language processing to Reddit comments about dermatology topics to assess for feasibility and potential for insights and engagement.A software pipeline preprocessed Reddit comments from 2005 to 2017 from seven popular dermatology-related subforums on Reddit, applied Latent Dirichlet allocation (LDA), and used spectral clustering to establish cohesive themes and the frequency of word representation and grouped terms within these topics.We created a corpus of 176K comments and identified trends in patient engagement in spaces such as eczema, acne, etc., with a focus on homeopathic treatments and Accutane.LDA is an unsupervised model, meaning there is no ground truth to which the model output can be compared. However, as these forums are anonymous, there seems little incentive for patients to be dishonest.Reddit data has viability and utility for dermatologic research and engagement with the public, especially for common dermatology topics such as tanning, acne, and psoriasis.

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