Noninflammatory comedones have greater diversity in microbiome and are more prone to biofilm formation than inflammatory lesions of acne vulgaris.

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The ability of Cutibacterium acnes strains to form biofilms has been correlated with their virulence.This study examined biofilm and skin microbiota in acne patients in order to understand their role […]

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Trends in the management of hidradenitis suppurativa in the Middle East region: a systematic review.

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Hidradenitis suppurativa (HS) is a chronic, painful, and severely debilitating inflammatory disease that affects apocrine gland-bearing skin. There is no universal consensus on the management of hidradenitis suppurativa (HS). Current […]

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Immunohistochemical analysis of the expression of selected cell lineage markers (CD4, CD8, CD68, c-Kit, Foxp3, CD56, CD20) in cutaneous variant of lichen planus.

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Lichen planus (LP) is considered to be an immune-mediated disease of a not fully understood etiology. There are scarce data on the immune cells forming the band-like infiltration in cutaneous […]

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Medical imaging examination in psoriasis and early psoriatic arthritis patients: an updated systematic review and meta-analysis.

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Psoriatic arthritis appears in one in four skin psoriasis patients. Early detection of the presence of joint involvement and early interception of its developments may minimize long-term functional disability, and the […]

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Metformin is associated with decreased risk of basal cell carcinoma: A whole-population case-control study from Iceland.

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Metformin has anti-carcinogenic properties and is also known to inhibit the Sonic hedgehog pathway, but no population-based studies exist analyzing the potential protective effect for basal cell carcinoma (BCC) and […]

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Phenotypes and therapeutic responses in cutaneous-predominant sarcoidosis

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Sarcoidosis is a chronic, multi-system disease characterized by non-necrotizing epithelioid granulomatous inflammation. Organ systems affected include the skin, respiratory tract, ocular, hepatobiliary, renal, cardiac, endocrine, neurological and musculoskeletal tissues [1, […]

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Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group.

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Case-control studies report a dose-dependent increased risk of skin cancer in users of hydrochlorothiazide (HCTZ) vs non-users. The degree to which other thiazides and thiazide-like diuretics (TZs) are associated with […]

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The status and outcomes of registered clinical trials for JAK inhibitors in alopecia areata: are non-published trials being overlooked?

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Recent meta-analyses of Janus kinase (JAK) inhibitors in alopecia areata (AA) have excluded trial registries and may thus be subject to publication bias. This study assessed the potential for evidence […]

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Risk of liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis receiving methotrexate: a population-based study.

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Patients with psoriatic disease may be more susceptible to methotrexate hepatotoxicity than those with rheumatoid arthritis (RA) but direct evidence is lacking.To compare liver disease risk among patients with psoriasis […]

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Baricitinib in patients with moderate-to-severe atopic dermatitis: Results from a randomized monotherapy Phase 3 trial in the United States and Canada (BREEZE-AD5).

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Baricitinib, an oral, selective Janus kinase (JAK)1/JAK2 inhibitor, is being studied for moderate-to-severe atopic dermatitis (AD) in adults.To evaluate the efficacy and safety of baricitinib monotherapy in a North American […]

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Hidradenitis suppurativa and chromosomal abnormalities: a case report and systematic review of the literature.

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Hidradenitis suppurativa (HS) is a chronic inflammatory follicular disorder that involves painful nodules, abscesses, and tunnels of intertriginous sites. Although the etiology has not been fully elucidated, recent studies have […]

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Hydroxychloroquine-induced acute generalized exanthematous pustulosis: a series of seven patients and review of the literature.

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Hydroxychloroquine (HCQ)-induced acute generalized exanthematous pustulosis (AGEP) is poorly described in the literature. The aim of our study was to characterize the clinical, laboratory, allergological, and genetic features of HCQ-induced […]

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The differential expression of EPHB4 and ephrin B2 in cutaneous squamous cell carcinoma according to the grade of tumor differentiation: a clinicopathological study.

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EPHB4 and its ligand, ephrin B2, which are receptor tyrosine kinases of the erythropoietin-producing hepatocellular (EPH) family, are known to be linked to several human cancers. The aim of this […]

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Phacomatosis spilosebacea: A new name for a distinctive binary genodermatosis.

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Phacomatosis pigmentokeratotica (PPK) is defined by the association of papular nevus spilus arranged in a flag-like pattern and sebaceous nevus following Blaschko’s lines. A systematic search of the worldwide literature retrieved […]

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Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib: a clinical validation study.

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Melanoma lacks validated blood-based biomarkers for monitoring and predicting treatment efficacy. Cell-free circulating tumour DNA (ctDNA) is a promising biomarker; however, various detection methods have been used, and, to date, […]

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Investigating the presence of neutrophil extracellular traps in septal and lobular cutaneous panniculitides.

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Panniculitides are a heterogeneous group of inflammatory dermatoses involving the subcutaneous fatty tissue. Histologically, they are classified into septal and lobular panniculitis, according to the predominant localization of the inflammatory […]

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Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016.

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Preservatives are often necessary components of commercial products. Large-scale North American studies on preservative allergy are limited.To evaluate demographics, positive patch test reactions (PPTRs), clinical relevance, and trends for preservatives tested […]

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British Association of Dermatologists (BAD) National Clinical Audit on the Management of Hidradenitis Suppurativa (HS) in the UK.

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The first UK guidelines for the management of hidradenitis suppurativa (HS) were published by the British Association of Dermatologists (BAD) in 2018. The guidelines contained a set of audit criteria.To […]

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Socio-economic status and skin cancer incidence: a population-based, cohort study in the province of Ferrara, northern Italy.

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To assess the weight of socio-economic status (SES) on the occurrence of skin cancer in the population living in the province of Ferrara, Italy, a retrospective cohort of patients, provided […]

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The “coloring wipes” phenomenon: a peculiar skin pigmentation induced by ascorbic acid observed during lockdown.

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During the SARS-CoV-2 pandemic, an outbreak of children with yellow-to-brown pigmentation on the skin was observed. Because of the restrictions on movements promulgated during the lockdown, most consultancies were performed […]

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Diagnosis of latent tuberculosis infection among pediatric household contacts of Iranian tuberculosis cases using tuberculin skin test, IFN- γ release assay and IFN-γ-induced protein-10.

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Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB […]

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The stratum corneum water content and natural moisturization factor composition evolve with age and depend on body site.

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The study objective was to examine if age and chronic environmental exposure affect the water content and the composition of the natural moisturizing factors (NMFs) of the stratum corneum (SC).Forty […]

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