Mathematical modeling and cellular automata simulation of infectious disease dynamics: Applications to the understanding of herd immunity.

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The complexity associated with an epidemic defies any quantitatively reliable predictive theoretical scheme. Here, we pursue a generalized mathematical model and cellular automata simulations to study the dynamics of infectious […]

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Acute Hypertriglyceridaemia Caused by Tocilizumab in a Patient with Severe COVID-19.

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Treatment with tocilizumab (TCZ) to block interleukin-6 (IL-6) signalling is predicted to mitigate cytokine release syndrome (CRS) caused by coronavirus disease 2019 (COVID-19). However, the adverse effects of TCZ on […]

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Computer-Aided Analysis of Multiple SARS-CoV-2 Therapeutic Targets: Identification of Potent Molecules from African Medicinal Plants.

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The COVID-19 pandemic, which started in Wuhan, China, has spread rapidly over the world with no known antiviral therapy or vaccine. Interestingly, traditional Chinese medicine helped in flattening the pandemic […]

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Regional extracorporeal membrane oxygenation retrieval service during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic: an interdisciplinary team approach to maintain service provision despite increased demand.

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Coronavirus disease 2019 is a new contagious disease that has spread rapidly across the world. It is associated with high mortality in those who develop respiratory complications and require admission […]

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Investigation of the frequency of COVID-19 in patients treated with intravesical BCG.

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In this retrospective study, we aimed to investigate the frequency of COVID-19 in patients with and without BCG application due to bladder tumors.The presence of COVID-19 was investigated in 167 […]

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Possible effect of epinephrine in minimizing COVID-19 severity: a review.

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Coronavirus disease 2019 (COVID-19) shows a wide range of severity, ranging from an asymptomatic presentation to a severe illness requiring intensive care unit admission. Identification of a strategy to manage […]

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Pancreatitis in a Patient with Severe Coronavirus Disease Pneumonia treated with Veno-venous Extracorporeal Membrane Oxygenation.

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Severe coronavirus disease (COVID-19) can induce serious complications, including acute respiratory distress syndrome, septic shock, and acute kidney injury. However, few reports have associated COVID-19 with pancreatitis. We herein report […]

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In Vitro Virucidal Effect of Intranasally Delivered Chlorpheniramine Maleate Compound Against Severe Acute Respiratory Syndrome Coronavirus 2.

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Background The initial global outbreak of the novel coronavirus disease 2019 (COVID-2019) pandemic, which is responsible for the severe acute respiratory syndrome 2 (SARS-CoV-2), shares similarities with the severe acute […]

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Venous thromboembolism in critically ill patients affected by ARDS related to COVID-19 in Northern-West Italy.

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Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. An association between increased venous thromboembolism in patients with […]

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Ethical dilemmas in COVID-19 times: how to decide who lives and who dies?

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The respiratory disease caused by the coronavirus SARS-CoV-2 (COVID-19) is a pandemic that produces a large number of simultaneous patients with severe symptoms and in need of special hospital care, […]

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N-terminally truncated nucleocapsid protein of SARS-CoV-2 as a better serological marker than whole nucleocapsid protein in evaluating the immunogenicity of inactive SARS-CoV-2.

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The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) had led to a serious public health crisis, and no specific treatments or vaccines are available yet. […]

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A Study on the Predictors of Disease Severity of COVID-19.

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BACKGROUND Early and rapid identification of severe coronavirus disease 2019 (COVID-19) cases is important. The present study aimed to investigate the predictors of disease severity and thus determine the trends […]

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Qt interval measurement with portable device during covid-19 outbreak.

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Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available. Overcrowded and under-resourced healthcare centres have had to design different strategies to treat these patients, what […]

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Imbalance between procoagulant factors and natural coagulation inhibitors contributes to hypercoagulability in the critically ill COVID-19 patient: clinical implications.

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Coronavirus Disease-2019 (COVID-19) predisposes patients to thrombosis which underlying mechanisms are still incompletely understood. We sought to investigate the balance between procoagulant factors and natural coagulation inhibitors in the critically […]

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Clinical and socioeconomic characteristics of older adults with COVID-19: A protocol for a rapid systematic review.

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The aim of this rapid systematic review is to analyze the prevalence of clinical, socioeconomic, and demographic characteristics, laboratory and imaging findings, diagnostic tests, and treatment information of older adults […]

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Convalescent Plasma for the Treatment of Patients with Severe Coronavirus Disease 2019; a Preliminary Report.

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The role of convalescent plasma therapy for patients with Coronavirus Disease 2019 (COVID-19) is unclear.We retrospectively compared outcomes in a cohort of critical COVID-19 patients who received standard care (SC […]

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Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2.

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The article highlights an up-to-date progress in studies of structure and the remedial aspects of novel coronavirus 2019-nCoV, renamed as SARS-CoV-2, leading to the disease COVID-19, a pandemic. In general, […]

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A Severe COVID-19 Case Complicated by Right Atrium Thrombus.

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BACKGROUND Recent studies demonstrated evidence of coagulation dysfunction in hospitalized patients with severe coronavirus disease 2019 (COVID-19) due to excessive inflammation, hypoxia, platelet activation, endothelial dysfunction, and stasis. Effective anticoagulation […]

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SARS-CoV-2 infection: NLRP3 inflammasome as plausible target to prevent cardiopulmonary complications?

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NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome has recently become an intriguing target of several chronic and viral diseases. Here, we argue that targeting NLRP3 inflammasome could be […]

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SARS-CoV-2 and the possible connection to ERs, ACE2, and RAGE: Focus on susceptibility factors.

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has provoked major stresses on the health-care systems of several countries, and caused the death of more than a quarter of […]

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The Role of Tocilizumab in Cytokine Storm and Improving Outcomes in COVID-19.

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To date, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of individuals around the world. This virus causes coronavirus disease 2019 (COVID-19) and has led to numerous deaths […]

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Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2.

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The outbreaks of severe acute respiratory syndrome (SARS) and Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV and SARS-CoV-2, respectively, have posed severe threats to global public health and the economy. […]

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