High value of Mid-regional proAdrenomedullin in COVID-19: a marker of widespread endothelial damage, disease severity and mortality.

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The widespread endothelial damage due to severe acute respiratory syndrome Coronavirus 2 (SARS-CoV2) may lead to a disruption of the adrenomedullin (ADM) system responsible for vascular leakage, increased inflammatory status, […]

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Psychological characteristics of parents in a Paediatric Outpatient during the SARS-CoV-2 Epidemic.

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With the outbreak and spread of the novel coronavirus (SARS-CoV-2), there has been a significant increase in the number of children infected, and some severe infection cases and neonatal cases […]

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Study design and operational framework for a community-based Malaria Elimination Demonstration Project (MEDP) in 1233 villages of district Mandla, Madhya Pradesh.

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In the past decade substantial reduction in malaria morbidity and mortality has been observed through well-implemented case management and vector control strategies. India has also achieved a significant reduction in […]

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Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals.

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Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1-3 and individuals with COVID-19 have symptoms that can be asymptomatic, mild, moderate or severe4,5. […]

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The Prolonged Use of VV ECMO Support in COVID-19: A Case Report.

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COVID-19 has resulted in unprecedented global health and economic challenges. The reported mortality in patients with COVID-19 requiring mechanical ventilation is high. VV ECMO may serve as a lifesaving rescue […]

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Neuroprognostication of Consciousness Recovery in a Patient with COVID-19 Related Encephalitis: Preliminary Findings from a Multimodal Approach.

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Predicting the functional recovery of patients with severe neurological condition due to coronavirus disease 2019 (COVID-19) is a challenging task. Only limited outcome data are available, the pathophysiology is poorly […]

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Chest CT in the Emergency Department for Diagnosis of COVID-19 Pneumonia: Dutch Experience.

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Background Clinicians need rapid and reliable diagnosis of coronavirus disease 2019 (COVID-19) for proper risk stratification, isolation strategies, and treatment decisions. Purpose To assess the real-life performance of radiologist emergency […]

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Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis.

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Coronavirus disease 2019 (COVID-19), a highly infectious disease, has been rapidly spreading all over the world and remains a great threat to global public health. Patients diagnosed with severe or […]

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[Proinflammatory cytokines and cardio-vascular risk: From myocardial infarction tocytokine storm of COVID-19].

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The mechanisms of inflammatory diseases involve the key inflammatory cytokines IL-1, TNF, IL-6, and IL-17 which are now therapeutic targets with biotherapies. They contribute to the local manifestations of clinically […]

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Right Heart Thrombus in an Adult COVID-19 Patient: A Case Report.

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Right heart thrombus (RiHTh) can be considered a rare and severe condition associated with thromboembolic phenomena. A case is described of a COVID-19 patient presenting with an isolated thrombus in […]

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Tocilizumab in hospitalized patients with COVID-19: Clinical outcomes, inflammatory marker kinetics, and safety.

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Coronavirus disease 2019 (COVID-19) due to infection with SARS-CoV-2 causes substantial morbidity. Tocilizumab, an interleukin-6 receptor antagonist, might improve outcomes by mitigating inflammation.We conducted a retrospective study of patients admitted […]

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A Giant Right-Heart Thrombus-in-Transit in a Patient with COVID-19 Pneumonia.

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BACKGROUND Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to more than 200 countries across the world. Studies have shown that patients with […]

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[Analysis of pathogenesis, syndrome differentiation and treatment of asymptomatic infectors of coronavirus disease 2019 based on the theory of “pathogen hiding in the pleurodiaphragmatic interspace”].

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Among coronavirus disease 2019 (COVID-19) patients who infected with 2019 novel coronavirus (2019-nCoV), compared with the symptomatic infection patients, 2019-nCoV carried by asymptomatic infection patients are more likely to be […]

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Coronary and cerebral thrombosis in a young patient after mild COVID-19 illness: a case report.

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COVID-19 has spread worldwide and has caused significant morbidity and mortality. Myocardial injury and thrombo-embolism are known complications for those with severe forms of disease. The incidence and risk factors […]

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Carbapenemase-producing Enterobacterales causing secondary infections during the COVID-19 crisis at a New York City hospital.

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Patients with COVID-19 may be at increased risk for secondary bacterial infections with MDR pathogens, including carbapenemase-producing Enterobacterales (CPE).We sought to rapidly investigate the clinical characteristics, population structure and mechanisms […]

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[Clinical characteristics of coronavirus disease 2019 patients complicated with pneumothorax: analysis of 7 cases].

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To analyze the clinical characteristics and prognosis of coronavirus disease 2019 (COVID-19) patients complicated with pneumothorax.The clinical data of 7 COVID-19 patients complicated with pneumothorax admitted to Huanggang Central Hospital […]

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Status of the Current COVID-19 Vaccine Candidates: Implications in the Saudi Population.

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The purpose of this review is to discuss the current status of local and international efforts undergoing clinical trials aiming at developing a Coronavirus Disease-2019 (COVID-19) vaccine, and to highlight […]

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Second Wave of COVID-19 Global Pandemic and Athletes’ Confinement: Recommendations to Better Manage and Optimize the Modified Lifestyle.

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Coronavirus 2019 (COVID-19) is an infectious viral disease that has spread globally, resulting in the ongoing pandemic. Currently, there is no vaccine or specific treatment for COVID-19. Preventive measures to […]

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Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data.

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The severity of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly heterogenous. Studies have reported that males and some ethnic groups are […]

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Racial and Ethnic Differences in Presentation and Outcomes for Patients Hospitalized with COVID-19: Findings from the American Heart Association’s COVID-19 Cardiovascular Disease Registry.

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Background: The COVID-19 pandemic has exposed longstanding racial/ethnic inequities in health risks and outcomes in the U.S.. We sought to identify racial/ethnic differences in presentation and outcomes for patients hospitalized […]

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Mechanical Ventilation Supply and Options for the COVID-19 Pandemic: Leveraging All Available Resources for a Limited Resource in a Crisis.

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The novel Coronavirus disease (COVID-19) has exposed critical supply shortages both in the United States and worldwide including those in ICU and hospital bed supply, hospital staff, and mechanical ventilators. […]

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[Diagnosis and treatment of community-acquired pneumonia in elderly patients combined with coronavirus disease 2019: analysis of 1 case].

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To explore the pathological characteristics and outcomes of elderly patients with community acquired pneumonia (CAP) accompanied by coronavirus disease 2019 (COVID-19).The diagnosis and treatment process of one elderly patient with […]

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The potential antiviral effect of major royal jelly protein2 and its isoform X1 against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Insight on their sialidase activity and molecular docking.

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Severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 is a newly emerging type of CoV. We evaluated the predicted anti-SARS-CoV-2 effect of major royal jelly protein (MRJP)2 and MRJP2 isoform X1, which recently […]

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A Multi-Pronged Approach Targeting SARS-CoV-2 Proteins Using Ultra-Large Virtual Screening.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019 novel coronavirus (2019-nCoV), has spread rapidly across the globe, creating an unparalleled global health burden and spurring a deepening […]

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