Observational Study of Metformin and Risk of Mortality in Patients Hospitalized with Covid-19.

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Background Type 2 diabetes (T2DM) and obesity are significant risks for mortality in Covid19. Metformin has been hypothesized as a treatment for COVID19. Metformin has sex specific immunomodulatory effects which […]

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Response to ‘the association between D-dimer in COVID-19 patients and mortality remains beset of uncertainties’.

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We appreciate the opportunity to respond Dr. Gris and colleagues who still have doubts about the predictive of D-dimer in COVID-19[1, 2]. We totally understand the concerns from Dr. Gris […]

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Methylprednisolone added to tocilizumab reduces mortality in SARS-CoV-2 pneumonia: An observational study.

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Although there are few randomized controlled trials (RCTs) evaluating the efficacy of drugs to treat COVID-19, different molecules have been used empirically and with great interest in those intended to […]

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Impact of SARS-CoV-2 Viral Load on Risk of Intubation and Mortality Among Hospitalized Patients with Coronavirus Disease 2019.

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Patients hospitalized with coronavirus disease 2019 (COVID-19) frequently require mechanical ventilation and have high mortality rates, but the impact of viral burden on these outcomes is unknown.We conducted a retrospective […]

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Diarrhea and altered inflammatory cytokine pattern in severe COVID-19: impact on disease course and in-hospital mortality.

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Dynamic changes of immunocyte subsets and inflammatory profiles in coronavirus disease 2019(COVID-19) patients with gastrointestinal symptoms were undetermined.A single center retrospective analysis of 409 severe hospitalized COVID-19 patients from Jan […]

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Factors associated with increased all-cause mortality during the COVID-19 pandemic in Italy.

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The number of excess deaths in February-March 2020 in Italy, in comparison to the previous years, was considerably higher than recorded COVID19-related deaths. The present study is aimed at exploring […]

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In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19.

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Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing […]

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Effect of social distancing on COVID-19 incidence and mortality in the US.

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Social distancing policies were implemented in most US states as a containment strategy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effectiveness of these policy interventions on morbidity and […]

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You Don’t Have To Be Infected To Suffer: COVID-19 and Racial Disparities in Severe Maternal Morbidity and Mortality.

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Both coronavirus disease 2019 (COVID-19) and maternal mortality disproportionately affect minorities. However, direct viral infection is not the only way that the former can affect the latter. Most adverse maternal […]

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Diabetes increases the mortality of patients with COVID-19: a meta-analysis.

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Nowadays, the ongoing pandemic of COVID-19 caused by the novel coronavirus Syndrome-Coronavirus-2 (SARS-CoV-2) is an emerging, rapidly evolving situation. Complications such as hypertension, diabetes, COPD, cardiovascular disease, and cerebrovascular disease […]

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Air Pollution and Covid-19: The Role of Particulate Matter in the Spread and Increase of Covid-19’s Morbidity and Mortality.

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Sars-cov-2 virus (Covid-19) is a member of the coronavirus family and is responsible for the pandemic recently declared by the World Health Organization. A positive correlation has been observed between […]

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Sociodemographic, clinical and laboratory factors on admission associated with COVID-19 mortality in hospitalized patients: A retrospective observational study.

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To identify and quantify associations between baseline characteristics on hospital admission and mortality in patients with COVID-19 at a tertiary hospital in Spain.This retrospective case series included 238 patients hospitalized […]

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Epidemiology of CoViD-19 Pandemic: Recovery and mortality ratio around the globe.

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Coronavirus Disease 2019 (CoViD-19) is the third type of coronavirus disease after severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) that appears in human population from the […]

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Could Sex/Gender Differences in ACE2 Expression in the Lungs Contribute to the Large Gender Disparity in the Morbidity and Mortality of Patients Infected With the SARS-CoV-2 Virus?

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COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and mortality in men. SARS-CoV-2 enters the lungs through the ACE2 enzyme, a member of the renin-angiotensin system (RAS). […]

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A simplified math approach to predict ICU beds and mortality rate for hospital emergency planning under Covid-19 pandemic.

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The different stages of Covid-19 pandemic can be described by two key-variables: ICU patients and deaths in hospitals. We propose simple models that can be used by medical doctors and […]

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Is the use of ACE inb/ARBs associated with higher in-hospital mortality in Covid-19 pneumonia patients?

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The present research aimed to determine the relation between the use of angiotensin-converting enzyme inhibitors (ACE inh) and angiotensinogen receptor blockers (ARBs) and in-hospital mortality of hypertensive patients diagnosed with […]

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Black-White Risk Differentials in COVID-19 (SARS-COV2) Transmission, Mortality and Case Fatality in the United States: Translational Epidemiologic Perspective and Challenges.

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Social and health inequities predispose vulnerable populations to adverse morbidity and mortality outcomes of epidemics and pandemics. While racial disparities in cumulative incidence (CmI) and mortality from the influenza pandemics […]

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Pharmacovigilance in patients with diabetes: A data-driven analysis identifying specific RAS antagonists with adverse pulmonary safety profiles that have implications for COVID-19 morbidity and mortality.

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The current demographic information from China reports that 10%-19% of patients hospitalized with coronavirus disease (COVID-19) were diabetic. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are considered […]

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Why case fatality ratios can be misleading: individual- and population-based mortality estimates and factors influencing them.

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Different ways of calculating mortality during epidemics have yielded very different results, particularly during the current COVID-19 pandemic. For example, the “CFR” has been interchangeably called the case fatality ratio, […]

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Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality.

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It has been hypothesized that angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) may make patients more susceptible to coronavirus disease 2019 (COVID-19) and to worse outcomes through upregulation of the […]

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