Association between trace levels of lithium in drinking water and COVID-19-associated mortality.

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Lithium, widely used in treating bipolar disorder, also exhibits antiviral activity.1 Lithium’s antiviral effects may extend to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-19), which causes coronavirus disease 2019 (COVID-19). […]

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Real Asymptomatic SARS-CoV-2 Infection Might Be Rare: Importance of Careful Interviews and Follow-up.

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There is limited information on the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) who are asymptomatic or have mild symptoms.We performed a retrospective case series of patients with […]

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Coronavirus disease-19 and cardiovascular disease: A risk factor or a risk marker?

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Severe acute respiratory syndrome coronavirus-2 causes the clinical syndrome of coronavirus disease of 2019 (COVID-19) which has become a global pandemic resulting in significant morbidity and mortality. While the virus […]

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Thrombo-inflammatory features predicting mortality in patients with COVID-19: The FAD-85 score.

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The roles of inflammation and hypercoagulation in predicting outcomes of coronavirus disease 2019 (COVID-19) are unclear.Adult patients diagnosed with COVID-19 from 28 January 2020 to 4 March 2020 in Tongji […]

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Ethnic differences in alpha-1 antitrypsin deficiency allele frequencies may partially explain national differences in COVID-19 fatality rates.

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Infection rates, severity, and fatalities due to COVID-19, the pandemic mediated by SARS-CoV-2, vary greatly between countries. With few exceptions, these are lower in East and Southeast Asian and Sub-Saharan […]

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Assessment of the efficacy and safety of Ribavirin in treatment of coronavirus-related pneumonia (SARS, MERS and COVID-19): A protocol for systematic review and meta-analysis.

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The new coronavirus-related pneumonia is causing a global pandemic without specific antiviral drug. Ribavirin has activity against extensive RNA and DNA viruses. We plan to systematically review the use of […]

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Patterns of COVID-19 testing and mortality by race and ethnicity among United States veterans: A nationwide cohort study.

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There is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease […]

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COVID19-world: a shiny application to perform comprehensive country-specific data visualization for SARS-CoV-2 epidemic.

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Data analysis and visualization is an essential tool for exploring and communicating findings in medical research, especially in epidemiological surveillance.Data on COVID-19 diagnosed cases and mortality, from January 1st, 2020, […]

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Does Universal Testing for COVID-19 Work for Everyone?

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The Coronavirus disease 2019 (COVID-19) pandemic has been especially devastating among nursing home residents, with both the health circumstances of individual residents as well as communal living settings contributing to […]

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COVID-19 hits a trial: Arguments against hastily deviating from the plan.

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The COVID-19 pandemic has substantially impacted the conduct of clinical trials. While initially preparing for a period of time, where it would likely be impossible to supervise trials in the […]

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Data monitoring committees for clinical trials evaluating treatments of COVID-19.

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The first cases of coronavirus disease 2019 (COVID-19) were reported in December 2019 and the outbreak of SARS-CoV-2 was declared a pandemic in March 2020 by the World Health Organization. […]

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Perspective on fibrinolytic therapy in COVID-19: the potential of inhalation therapy against suppressed-fibrinolytic-type DIC.

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A high rate of thrombotic complications, such as pulmonary embolism, has been linked to mortality in COVID-19, and appropriate treatment of thrombosis is important for lifesaving. Although heparin is frequently […]

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Do free radical NETwork and oxidative stress disparities in African Americans enhance their vulnerability to SARS-CoV-2 infection and COVID-19 severity?

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This review focuses on the hypothetical mechanisms for enhanced vulnerability of African Americans to SARS-CoV-2 infection, COVID-19 severity, and increased deaths. A disproportionately higher number of African Americans are afflicted […]

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Does Asthma Increase the Mortality of Patients with COVID-19?: A Systematic Review and Meta-Analysis.

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The purpose of this systematic review and meta-analysis was to explore the literature and collate data comparing the mortality of coronavirus disease 2019 (COVID-19) patients with and without asthma. The […]

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[Most important vaccinations in patients with rheumatological diseases and why].

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For a long time, most of the infectious diseases seemed to have become under control. In particular, vaccinations have contributed to this development. In recent years newly occurring bacterial infections caused […]

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Core Elements of a National COVID-19 Strategy: Lessons Learned from the US National HIV/AIDS Strategy.

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COVID-19 has caused devastating health consequences and social inequities globally and in the United States. Unfortunately, the US has not developed a comprehensive National COVID-19 Strategy. In this editorial, we […]

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Pregnancy and COVID-19: Pharmacologic Considerations.

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The Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV2) pandemic has sparked controversy regarding the use of certain routine and investigational pharmacologic interventions during pregnancy and the postpartum period. In this review, […]

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Carbohydrate-Binding Agents: Potential of Repurposing for COVID-19 Therapy.

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With the emergence of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the whole world is suffering from atypical pneumonia which resulted in more than 559,047 deaths worldwide. In this […]

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Maternal deaths in Brazil from severe COVID-19 respiratory disease: Time for a global commitment to ending health disparities.

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In this issue, Takemoto M. et al. report on 124 maternal deaths among individuals with SARS-CoV-2 attributable acute respiratory distress syndrome (ARDS) in Brazil leveraging an ARDS surveillance system established […]

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Characteristics of a Diverse Cohort of Stroke Patients with SARS-CoV-2 and Outcome by Sex.

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is associated with stroke. The role of sex on stroke outcome has not been investigated. To objective of this paper is to […]

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Cellular senescence as a potential mediator of COVID-19 severity in the elderly.

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SARS-CoV-2 is a novel betacoronavirus which infects the lower respiratory tract and can cause coronavirus disease 2019 (COVID-19), a complex respiratory distress syndrome. Epidemiological data show that COVID-19 has a rising […]

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