Heterogeneity in presentation of hyperglycaemia during COVID-19 pandemic: A proposed classification.

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Diabetes and hyperglycemia occurring during COVID-19 era have implications for COVID-19 related morbidity/mortality. In this brief review, we have attempted to categorise and classify such heterogenous hyperglycemic states. During COVID-19 […]

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Risk of adverse COVID-19 outcomes for people living with HIV: a rapid review and meta-analysis.

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To assess whether people living with HIV (PLWH) are at increased risk of COVID-19 mortality or adverse outcomes, and whether antiretroviral therapy (ART) influences this risk.Rapid review with meta-analysis and […]

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Clinical course of SARS-CoV-2 infection in patients with severe acquired brain injury and a disorder of consciousness: an observational study.

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Purpose: SARS-CoV-2 infection can cause the coronavirus disease (COVID), ranging from flu-like symptoms to interstitial pneumonia. Mortality is high in COVID pneumonia and it is the highest among the frailest. […]

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Effectiveness of glucocorticoids in patients hospitalized for severe SARS-CoV-2 pneumonia.

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Several studies have reported the beneficial effect of glucocorticoids in the treatment of cytokine storm that occurs in patients with severe COVID-19. Various glucocorticoids regimens have been proposed.Retrospective observational study […]

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Clinical outcomes of initially asymptomatic patients with COVID-19: a Korean nationwide cohort study.

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This study was performed to compare severe clinical outcome between initially asymptomatic and symptomatic infections and to identify risk factors associated with high patient mortality among initially asymptomatic patients.In this […]

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Investigating connections between COVID-19 pandemic, air pollution and community interventions for Pakistan employing geoinformation technologies.

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Several major cities that witnessed heavy air pollution by particulate matter (PM2.5) concentration and nitrogen dioxide (NO2) have contributed to high rate of infection and severity of the coronavirus disease […]

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Therapeutic opportunities of edible antiviral plants for COVID-19.

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The pandemic of Serious Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) that produces corona virus disease (COVID-19) has challenged the entire mankind by rapidly spreading globally in 210 countries affecting over […]

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Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study.

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Background: Convalescent plasma is a potential therapeutic option for critically ill patients with coronavirus disease 19 (COVID-19), yet its efficacy remains to be determined. The aim was to investigate the […]

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Thrombo-inflammatory Biomarkers in COVID-19: Systematic Review and Meta-analysis of 17,052 patients.

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To evaluate differences in thrombo-inflammatory biomarkers between patients with severe COVID-19 infection/death and mild infection.Medline, Cochrane Central Register of Controlled Trials, Embase, EBSCO, Web of Science, and CINAHL databases were […]

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Characterizing a two-pronged epidemic in Mexico of non-communicable diseases and SARS-Cov-2: factors associated with increased case-fatality rates.

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People with a previous diagnosis of non-communicable diseases (NCDs) are more likely to develop serious forms of COVID-19 or die. Mexico is the country with the fourth highest fatality rate […]

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Low thoracic skeletal muscle area is not associated with negative outcomes in patients with COVID-19.

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Sarcopenia has been related to negative outcomes in different clinical scenarios from critical illness to chronic conditions. The aim of this study was to verify if there was an association […]

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Thrombotic complications in 2928 patients with COVID-19 treated in intensive care: a systematic review.

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A prothrombotic state is reported with severe COVID-19 infection, which can manifest in venous and arterial thrombotic events. Coagulopathy is reflective of more severe disease and anticoagulant thromboprophylaxis is recommended […]

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Induced dysregulation of ACE2 by SARS-CoV-2 plays a key role in COVID-19 severity.

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of COVID-19, is reported to increase the rate of mortality worldwide. COVID-19 is associated with acute respiratory symptoms as well as blood […]

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Biological responses to COVID-19: Insights from physiological and blood biomarker profiles.

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Understanding the spectrum and course of biological responses to coronavirus disease 2019 (COVID-19) may have important therapeutic implications. We sought to characterise biological responses among patients hospitalised with severe COVID-19 […]

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Mortality Benefit of Remdesivir in COVID-19: A Systematic Review and Meta-Analysis.

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Importance/Background: During current public health emergency of COVID-19 pandemic, repurposing of existing antiviral drugs may be an efficient strategy since there is no proven effective treatment. Published literature shows Remdesivir […]

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Disease Severity, Fever, Age, and Sex Correlate With SARS-CoV-2 Neutralizing Antibody Responses.

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Clinical trials on the use of COVID-19 convalescent plasma remain inconclusive. While data on safety is increasingly available, evidence for efficacy is still sparse. Subgroup analyses hint to a dose-response […]

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Atrial fibrillation in patients with COVID-19. Usefulness of the CHA2DS2-VASc score: an analysis of the international HOPE COVID-19 registry.

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Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Atrial fibrillation (AF) is common in acute situations, where it is associated with more complications and higher […]

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Diarrhoea in adults with coronavirus disease-beyond incidence and mortality: a systematic review and meta-analysis.

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Diarrhoea is a relatively common manifestation of coronavirus disease (COVID-19), but there is no systematic review which comprehensively describes it beyond its incidence and impact on prognosis. This study aims […]

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Arrhythmias in patients with coronavirus disease 2019 (COVID-19) in Wuhan, China: Incidences and implications.

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Coronavirus disease 2019 (COVID-19) continues to impact populations around the globe. Information regarding the incidences and implications of arrhythmias in COVID-19 is limited.A total of 463 patients with COVID-19 and […]

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Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury.

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The cytokine storm or cytokine storm syndrome (CSS) is associated with high mortality in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), for example following sepsis […]

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3044 cases reveal important prognosis signatures of COVID-19 patients.

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Critical patients and intensive care unit (ICU) patients are the main population of COVID-19 deaths. Therefore, establishing a reliable method is necessary for COVID-19 patients to distinguish patients who may […]

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Neutrophil-to-Lymphocyte, Lymphocyte-to-Monocyte, and Platelet-to-Lymphocyte Ratios: Prognostic Significance in COVID-19.

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Background and objective Neutrophils are primarily responsible for activating the immune system, and systemic inflammation destroys CD4+ T lymphocytes and increases suppressor CD8+ T lymphocytes, thereby leading to an increased […]

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“Tocilizumab-an option for patients with COVID-19 associated cytokine release syndrome: A single center experience”, a retrospective study-original article.

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The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China in 2019. In the first half of 2020, this disease has already […]

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COVID-19: Imbalanced Immune Responses and Potential Immunotherapies.

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The ongoing pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading and has resulted in grievous morbidity and mortality worldwide. Despite the […]

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Global Quality Statements on Reliever Use in Asthma in Adults and Children Older than 5 Years of Age.

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Widespread misuse of short-acting beta-agonists (SABAs) may contribute to asthma-related morbidity and mortality. Recognizing this, the Global Initiative for Asthma neither recommends SABA monotherapy nor regards this formulation as a […]

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COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors.

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Most studies of severe/fatal COVID-19 risk have used routine/hospitalisation data without detailed pre-morbid characterisation. Using the community-based UK Biobank cohort, we investigate risk factors for COVID-19 mortality in comparison with […]

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COVID-19 Infection in Critically Ill Patients Carries a High Risk of Venous Thrombo-embolism.

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The coronavirus disease of 2019 (COVID-19) due to SARS-CoV-2 infection has been found to cause an increased risk of venous thrombo-embolism (VTE). The aims of the study were to determine […]

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Safety and efficacy of convalescent plasma in elderly COVID-19 patients: the RESCUE trial.

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To assess the safety and efficacy of convalescent plasma (CP) transfusion in elderly people with moderate to severe COVID-19 living in a long-term care facility (LTCF).Twenty-two consecutive elderly COVID-19 patients […]

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