Immediate post-procedural functional assessment of percutaneous coronary intervention: current evidence and future directions.

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Percutaneous coronary intervention (PCI) guided by coronary physiology provides symptomatic benefit and improves patient outcomes. Nevertheless, over one-fourth of patients still experience recurrent angina or major adverse cardiac events following […]

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Intensive low-density lipoprotein cholesterol lowering in cardiovascular disease prevention: opportunities and challenges.

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Elevated levels of low-density lipoprotein cholesterol (LDL-C) are associated with increased risk of coronary heart disease and stroke. Guidelines for the management of dyslipidaemia from the European Society of Cardiology […]

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Exercise Performance in Adolescents with Fontan Physiology (From the Pediatric Heart Network Fontan Public Data Set).

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In the pediatric population, exercise capacity differs between females and males and the gap widens through adolescence. However, specific age- and sex-based changes in adolescents with congenital heart disease and […]

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The Burden of Radiation Exposure During Transcatheter Closure of Atrial Septal Defect.

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Radiation reduction in the pediatric cardiac catheterization laboratory is well-suited for targeted quality improvement (QI) interventions. Transcatheter atrial septal defect (ASD) closure was chosen for this QI project based on […]

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P2Y12 inhibitor monotherapy after coronary stenting according to type of P2Y12 inhibitor.

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To compare P2Y12 inhibitor monotherapy after 3-month dual antiplatelet therapy (DAPT) with 12-month DAPT according to the type of P2Y12 inhibitor in patients undergoing percutaneous coronary intervention (PCI).The Smart Angioplasty […]

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Long-Term Prognostic Value of the Society of Thoracic Surgery Risk Score in Patients Undergoing Transcatheter Aortic Valve Implantation (From the OCEAN-TAVI Registry).

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The Society of Thoracic Surgeons (STS) risk model, designed to predict operative mortality after cardiac surgery, is often used for the risk assessment of patients considered for transcatheter aortic valve […]

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Pre-Diabetic Patient Outcomes 8-15 Years after Drug-Eluting Coronary Stenting.

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Guidelines suggest differential management of diabetics and non-diabetics with coronary artery disease (CAD) referred for revascularization, but pre-diabetics, who now comprise up to 20-30% of CAD patients, have been excluded […]

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Ten-year Mortality in Patients with ST-Elevation Myocardial Infarction.

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Knowledge of the long-term prognosis (>10 years) and mortality predictors of ST-elevation myocardial infarction (STEMI) patients who have undergone primary percutaneous coronary intervention (p-PCI) is scarce. Therefore, this study evaluated […]

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Association between prophylactic angiotensin-converting enzyme inhibitors and overall survival in Duchenne muscular dystrophy-analysis of registry data.

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To estimate the effect of prophylactic angiotensin-converting enzyme inhibitors (ACEi) on survival in Duchenne muscular dystrophy (DMD).We analysed the data from the French multicentre DMD Heart Registry (ClinicalTrials.gov: NCT03443115). We […]

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Prasugrel versus ticagrelor in patients with myocardial infarction undergoing percutaneous coronary intervention.

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The comparative efficacy and safety of prasugrel and ticagrelor in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI) remain unclear. We aimed to investigate the association of […]

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Role and Timing of Aspirin Therapy Following PCI in Patients With Atrial Fibrillation.

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In patients with atrial fibrillation who undergo percutaneous coronary intervention (PCI), both anticoagulation and dual antiplatelet therapy (aspirin plus a P2Y12 inhibitor) are indicated. However, this “triple” antithrombotic therapy is […]

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Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA.

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The post-discharge outcomes of patients with cancer who undergo PCI are not well understood. This study evaluates the rates of readmissions within 90 days for acute myocardial infarction (AMI) and bleeding […]

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Comparison of Long-Term Outcomes After Percutaneous Coronary Intervention in Patients With Insulin-Treated vs. Non-Insulin Treated Diabetes Mellitus.

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There are conflicting data on whether patients with insulin-treated diabetes mellitus (ITDM) have poorer outcomes compared to non-insulin treated diabetic (non-ITDM) patients following percutaneous coronary intervention (PCI). We therefore compared […]

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Outcomes of Individuals With and Without Heart Failure Presenting With Acute Coronary Syndrome.

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Major adverse cardiac event (MACE) and bleeding risks following percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS) are not well defined in individuals with heart failure (HF). We followed […]

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Reasons for Screen Failure for Transcatheter Mitral Valve Repair and Replacement.

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Despite an expanding armamentarium of devices, many patients with mitral regurgitation referred for transcatheter mitral valve repair (TMVr) or replacement (TMVR) do not meet strict clinical trial inclusion and exclusion […]

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Relation of Institutional Mitral Valve Surgical Volume to Surgical and Transcatheter Outcomes in Medicare Patients.

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There are limited data to support proposed increases to the minimum institutional mitral valve (MV) surgery volume required to begin a transcatheter mitral valve repair (TMVr) program. The current study […]

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Impact of Ventricular Stroke Work Indices on Mortality in Heart Failure Patients after Percutaneous Mitral Valve Repair.

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Optimal patient selection for transcatheter mitral valve repair (TMVR) remains challenging. The aim of the study was to assess the impact of left and right ventricular stroke work index (LVSWi, […]

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Meta-Analysis of Sex Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction.

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Sex disparities in ST-segment elevation myocardial infarction (STEMI) outcomes continue to be reported worldwide; however, the magnitude of this gap remains unknown. To evaluate gender-based discrepancies in clinical outcomes and […]

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Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo.

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The rapid endothelialization of bare metal stents (BMS) is counterbalanced by inflammation-induced neointimal growth. Drug-eluting stents (DES) prevent leukocyte activation but impair endothelialization, delaying effective device integration into arterial walls. […]

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Socioeconomic disparities in prehospital factors and survival after out-of-hospital cardiac arrest.

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It remains unknown whether patient socioeconomic factors affect interventions and survival after out-of-hospital cardiac arrest (OHCA), and whether a socioeconomic effect on bystander interventions affects survival. Therefore, this study examined […]

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The neutrophil-lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials.

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The neutrophil-lymphocyte ratio (NLR) is a readily available inflammatory biomarker that may associate with atherosclerosis and predict cardiovascular (CV) events. The aims of this study are to determine whether the […]

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Comparison of the Efficacy and Safety of Sacubitril/Valsartan versus Ramipril in Patients with ST-Segment Elevation Myocardial Infarction.

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The role of sacubitril/valsartan in patient with heart failure (HF) is established. Whether sacubitril/valsartan plays a role in improving outcomes in patients after ST-segment elevation myocardial infarction (STEMI) is unknown. […]

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Comparison of Outcomes Among Patients with Cardiogenic Shock Admitted on Weekends versus Weekdays.

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Cardiogenic shock (CS) is associated with high mortality and often requires involvement of a multidisciplinary provider team to deliver timely care. Care coordination is more difficult on weekends, which may […]

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Improvement in left ventricular mechanics following medical treatment of constrictive pericarditis.

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Patients with constrictive pericarditis (CP) with active inflammation may show resolution with anti-inflammatory therapy. We aimed to investigate the impact of anti-inflammatory medications on constrictive pathophysiology using echocardiography in patients […]

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Incidence, Management, Immediate and Long-Term Outcome of Guidewire and Device Related Grade III Coronary Perforations (From G3CAP – Cardiogroup VI registry).

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Ellis grade III coronary artery perforations (G3-CAP) remain a life-threatening complication of PCI, with high morbidity and mortality and lack of consensus regarding optimal treatment strategies. We reviewed all PCIs […]

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