Association between self-reported functional capacity and major adverse cardiac events in patients at elevated risk undergoing noncardiac surgery: a prospective diagnostic cohort study.

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Perioperative cardiovascular guidelines endorse functional capacity estimation, based on ‘cut-off’ daily activities for risk assessment and climbing two flights of stairs to approximate 4 metabolic equivalents. We assessed the association […]

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The effect of COVID-19 on general anaesthesia rates for caesarean section. A cross sectional analysis of six hospitals in the north-west of England.

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At the onset of the global pandemic of COVID-19 (SARS-CoV-2), guidelines recommended using regional anaesthesia for caesarean section in preference to general anaesthesia. National figures from the UK suggest that […]

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An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients.

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This international multidisciplinary consensus statement was developed to provide balanced guidance on the safe peri-operative use of opioids in adults. An international panel of healthcare professionals evaluated the literature relating […]

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Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial.

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Intravenous tranexamic acid (TXA) reduces bleeding deaths after injury and childbirth. It is most effective when given early. In many countries, pre-hospital care is provided by people who cannot give […]

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Safety and 30-day outcomes of tracheostomy for COVID-19: a prospective observational cohort study.

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The role of tracheostomy in coronavirus disease 2019 (COVID-19) is unclear, with several consensus guidelines advising against this practice. We developed both a dedicated airway team and coordinated education programme […]

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General anaesthetic and airway management practice for obstetric surgery in England: a prospective, multicentre observational study.

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There are no current descriptions of general anaesthesia characteristics for obstetric surgery, despite recent changes to patient baseline characteristics and airway management guidelines. This analysis of data from the direct […]

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Lactate versus acetate buffered intravenous crystalloid solutions: a scoping review.

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Buffered crystalloid solutions are increasingly recommended as first-line intravenous resuscitation fluids. However, guidelines do not distinguish between the different types of buffered solutions. The aim of this scoping review was […]

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Utility of changes in end-tidal carbon dioxide after volume expansion to assess fluid responsiveness in the operating room: a prospective observational study.

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From a physiological viewpoint, changes in end-tidal carbon dioxide (EtCO2) could be a simple, noninvasive, and inexpensive way to monitor changes in cardiac index. This study aimed to assess the […]

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A multi-dimensional analysis of genotype-phenotype discordance in malignant hyperthermia susceptibility.

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Malignant hyperthermia (MH) susceptibility is an inherited condition, diagnosed either by the presence of a pathogenic genetic variant or by in vitro caffeine-halothane contracture testing. Through a multi-dimensional approach, we describe […]

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A Case Report of Slowly Evolving Epidural Hematoma After Lumbar Drain Removal Following Initiation of Clopidogrel Therapy.

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Guidelines on the management of lumbar drain in patients receiving antithrombotic therapy are lacking, with American Society of Regional Anesthesia and Pain Medicine (ASRA) anticoagulation guidelines for regional anesthesia providing […]

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Guideline on anaesthesia and sedation in breastfeeding women 2020: Guideline from the Association of Anaesthetists.

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Breastfeeding has many health benefits for the mother and infant. Women who are breastfeeding may require anaesthesia or sedation. Concerns regarding the passage of drugs into breast milk may lead […]

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Association of intraoperative anaesthesia handovers with patient morbidity and mortality: a systematic review and meta-analysis.

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Handover of anaesthesia patient care during surgery is common; however, its association with patient outcome is unclear. This systematic review aimed to assess the impact of anaesthesia handover during surgery […]

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A European consensus statement on the use of four-factor prothrombin complex concentrate for cardiac and non-cardiac surgical patients.

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Modern four-factor prothrombin complex concentrate was designed originally for rapid targeted replacement of the coagulation factors II, VII, IX and X. Dosing strategies for the approved indication of vitamin K […]

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Analysis of practices to promote reproducibility and transparency in anaesthesiology research.

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Reliable, high-quality research is essential to the field of anaesthesiology. Reproducibility and transparency have been investigated in the biomedical domain and in the social sciences, with both lacking to provide […]

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Availability of dantrolene for the management of malignant hyperthermia crises: European Malignant Hyperthermia Group guidelines.

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Faced with a malignant hyperthermia crisis, the immediate access to sufficient dantrolene is essential to achieve the best possible outcome for the patient. However, malignant hyperthermia crises are rare, and […]

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Guidelines: Anaesthesia in the context of COVID-19 pandemic.

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The world is currently facing an unprecedented healthcare crisis caused by COVID-19 pandemic. The objective of these guidelines is to produce a framework to facilitate the partial and gradual resumption […]

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Pain after External and Endonasal Septorhinoplasty-A Propensity Score Matching Analysis.

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Guidelines for pain management following septorhinoplasty are lacking, leading to a wide range of therapy regimes even including opioid medication. Thus, the presented study strived to investigate and compare postoperative […]

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Early nephrectomy in neonates with symptomatic autosomal recessive polycystic kidney disease.

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Autosomal recessive polycystic kidney disease (ARPKD) is a rare cause of renal failure with a highly variable clinical course. Patients who are symptomatic early in life frequently require early nephrectomy […]

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A systematic review of pain outcomes reported by randomised trials of hip and knee arthroplasty.

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It is difficult to pool results from randomised clinical trials that report different outcomes. We want to develop a core set of pain-related outcomes after total hip or knee arthroplasty, […]

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Impact of a risk-stratified thromboprophylaxis protocol on the incidence of postoperative venous thromboembolism and bleeding.

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Efforts to reduce postoperative venous thromboembolism are challenging due to heterogeneity in thromboprophylaxis practice. As a result, a ‘one-size-fits-all’ approach that accounts for surgery-specific risk, but fails to account for […]

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Efficacy and acceptability of pharmacological and non-pharmacological interventions for non-specific chronic low back pain: a protocol for a systematic review and network meta-analysis.

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Despite the enormous financial and humanistic burden of chronic low back pain (CLBP), there is little consensus on what constitutes the best treatment options from a multitude of competing interventions. […]

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Laparoscopic-Guided Transversus Abdominis Plane Block for Postoperative Pain Management in Minimally Invasive Surgery: Systematic Review and Meta-Analysis.

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Optimal postoperative pain therapy for patients undergoing minimally invasive surgery remains controversial. The aim of this meta-analysis was to compare the efficacy and safety of the novel laparoscopic-guided transversus abdominis […]

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Airway management in the operating room and interventional suites in known or suspected COVID-19 adult patients: a practical review.

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Current evidence suggests that Coronavirus Disease 2019 (COVID-19) spread occurs via respiratory droplets (particles >5 µm), and possibly through aerosol. The rate of transmission remains high during airway management. This […]

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Infection control of operating room and anesthesia for cesarean section during pandemic Coronavirus disease-19 (COVID-19) outbreak in Daegu, the republic of Korea – 8 cases report.

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Since the Coronavirus diseases-19 (COVID-19) was reported in Wuhan, China, Korea has also been exposed to the virus. In Korea, COVID-19 screening guidelines have been established in each hospital, trying […]

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Impact of a perioperative oral opioid substitution protocol during the nationwide intravenous opioid shortage: A single center, interrupted time series with segmented regression analysis.

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To mitigate the recent nationwide shortage of intravenous opioids, we developed a standardized perioperative oral opioid guideline anchored with appropriate use of nonopioid analgesia, neuraxial and loco-regional techniques. We hypothesize […]

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