Nociception-monitor-guided opioid administration in radical retropubic prostatectomy: a randomised controlled trial.

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This RCT investigated the effect of opioid titration by three different nociception monitoring devices or clinical signs during general anaesthesia.Ninety-six patients undergoing radical retropubic prostatectomy with propofol/remifentanil anaesthesia were randomised […]

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Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study.

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Postoperative delirium is associated with increases in the neuronal injury biomarker, neurofilament light (NfL). Here we tested whether two other biomarkers, glial fibrillary acidic protein (GFAP) and tau, are associated […]

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Non-invasive haemoglobin measurement as an index test to detect pre-operative anaemia in elective surgery patients – a prospective study.

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Non-invasive haemoglobin measurement using absolute values lacks the precision to be the sole basis for the treatment of pre-operative anaemia. However, it can possibly serve as a screening test, indexing […]

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Intraoperative opioids are associated with improved recurrence-free survival in triple-negative breast cancer.

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Opioid-induced immunomodulation may be of particular importance in triple-negative breast cancer (TNBC) where an immune response is associated with improved outcome and response to immunotherapy. We evaluated the association between […]

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Socioeconomic deprivation and long-term outcomes after elective surgery: analysis of prospective data from two observational studies.

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Socioeconomic deprivation is associated with health inequalities. We explored relationships between socioeconomic group and outcomes after elective surgery in the UK National Health Service (NHS).We combined data from two observational […]

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Temporal trends in the incidence of post-dural puncture headache following labor neuraxial analgesia in the United States, 2006 to 2015.

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Labor neuraxial analgesia utilization has increased in the United States (U.S.) but its impact on maternal safety is unknown. This study analyzed the temporal trends in the incidence of post-dural […]

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A systematic review of the association between postpartum depression and neuraxial labor analgesia.

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Postpartum depression (PPD) is the most common complication after childbirth, affecting 10-15% of women. It is associated with serious long-term consequences for the mother and family. Whether or not neuraxial […]

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Epidural analgesia, intrapartum hyperthermia, and neonatal brain injury: a systematic review and meta-analysis.

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Epidural analgesia is associated with intrapartum hyperthermia, and chorioamnionitis is associated with neonatal brain injury. However, it is not known if epidural hyperthermia is associated with neonatal brain injury. This […]

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Minimising exposure to droplet and aerosolised pathogens: a computational fluid dynamics study.

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Hazardous pathogens are spread in either droplets or aerosols produced during aerosol-generating procedures (AGP). Adjuncts minimising exposure of healthcare workers to hazardous pathogens released during AGP may be beneficial. We […]

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Intelligent checklists improve checklist compliance in the intensive care unit: a prospective before-and-after mixed-method study.

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We examined whether a context and process-sensitive ‘intelligent’ checklist increases compliance with best practice compared with a paper checklist during intensive care ward rounds.We conducted a single-centre prospective before-and-after mixed-method […]

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The Haemostasis Traffic Light, a user-centred coagulation management tool for acute bleeding situations: a simulation-based randomised dual-centre trial.

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The Haemostasis Traffic Light is a cognitive aid with a user-centred design to enhance and simplify situation awareness and decision-making during peri-operative bleeding. Its structure helps to prioritise therapeutic interventions […]

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PROSPECT guideline for tonsillectomy: systematic review and procedure-specific postoperative pain management recommendations.

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Tonsillectomy is one of the most frequently performed surgical procedures; however, pain management remains challenging. Procedure-specific efficacy as well as specific risks of treatment options should guide selection of pain […]

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Subcutaneous fentanyl for labour analgesia: a retrospective case note review.

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In 2017, a South Australia Perinatal Practice Guideline was introduced state-wide for the use of subcutaneous fentanyl for labour analgesia as a replacement for intramuscular pethidine. We retrospectively reviewed the […]

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Obstructive sleep apnea is associated with adverse maternal outcomes using a United States multistate database cohort, 2007-2014.

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Obstructive sleep apnea affects approximately 11% of women of reproductive age, although it is often undetected and untreated. Previous studies suggest an association between obstructive sleep apnea and adverse maternal […]

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Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates.

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Clinical studies show that children exposed to anaesthetics for short times at young age perform normally on intelligence tests, but display altered social behaviours. In non-human primates (NHPs), infant anaesthesia […]

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Association between cerebrospinal fluid biomarkers of neuronal injury or amyloidosis and cognitive decline after major surgery.

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Postoperative neurocognitive decline is a frequent complication in adult patients undergoing major surgery with increased risk for morbidity and mortality. The mechanisms behind cognitive decline after anaesthesia and surgery are […]

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Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: an abridged Cochrane network meta-analysis‡§.

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Postoperative nausea and vomiting is a common adverse effect of anaesthesia. Although dozens of different anti-emetics are available for clinical practice, there is currently no comparative ranking of efficacy and […]

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Desflurane and sevoflurane differentially affect activity of the subthalamic nucleus in Parkinson’s disease.

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Desflurane and sevoflurane are commonly used during inhalational anaesthesia, but few studies have investigated their effects on deep cerebral neuronal activity. In addition, the association between subthalamic nucleus (STN) neurophysiology […]

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Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study.

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Myocardial and neuronal injury occur commonly after noncardiac surgery. We examined whether patients who had perioperative myocardial injury (PMI) also incurred neuronal injury, and whether myocardial and neuronal injury were […]

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Prone positioning for patients intubated for severe acute respiratory distress syndrome (ARDS) secondary to COVID-19: a retrospective observational cohort study.

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The role of repeated prone positioning in intubated subjects with acute respiratory distress syndrome caused by COVID-19 remains unclear.We conducted a retrospective observational cohort study of critically ill intubated patients […]

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Apparent Reversal of a Successful Peripheral Neural Blockade With Intravenous Lipid Emulsion After Treatment for Local Anesthetic Systemic Toxicity: A Case Report.

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The use of local anesthetics for improved pain management is well established. However, significant morbidity may be caused by local anesthetic systemic toxicity (LAST) from inadvertent intravascular injection or excessive […]

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