Biocompatibility and mechanical properties evaluation of chitosan films containing an N-acylhydrazonic derivative.

Please login or register to bookmark this article
Bookmark this %label%

The N-acylhydrazone subunit is considered a privileged structure in medicinal chemistry for its importance in pharmaceutical research. Also, alternative methods to deliver these molecules have a great pharmaceutical interest. Therefore, the objective of this work was to encapsulate JR19, an N-acyl hydrazone subunit, into chitosan films and evaluate several properties relevant for transdermal delivery, including biocompatibility using in vitro tests. CHI + JR19 film demonstrates greater strength, flexibility, water absorption capacity, low contact angle and higher surface roughness when compared to CHI. Agar diffusion and 3-(4,5-dimethyl)-2,5-diphenyl tetrazolium bromide (MTT) assay show the absence of cytotoxicity and the higher cell viability for CHI + JR19 films. Therefore, the addition of JR19 in the system positively influenced mechanical properties and granted better compatibility with biological environments, showing the potential to treat skin inflammation.

Get PDF with LibKey
View the article @ European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (sign-in may be required)