Bile formation and Secretion: An update.

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Bile formation is a fundamental physiological process that is vital to the survival of all vertebrates. However little was known about the mechanisms of this secretion until after WWII. Initial studies involved classic physiologic studies in animal models and man but progressed to include studies in isolated cells and membrane vesicles until the advent of molecular biology which led to the identification of specific transport systems that are the determinants of this secretion. Progress in this field was reviewed in the American Physiologic Society’s series on “Comprehensive Physiology” in 2013. Here we provide an in-depth update of progress since that time.

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Authors: James Lorenzen Boyer, Carol Jean Soroka