Allergic Rhinitis and Obstructive Sleep Apnea in Children Residing at High-Altitude.
Obstructive sleep apnea (OSA) affects 2-4 % of the pediatric population; allergic rhinitis (AR) has been identified as a risk factor in sleep-disordered-breathing, but no studies evaluating such association have been conducted in high altitude environments. We aimed to assess whether the severity of AR is associated with the severity of OSA in children undergoing polysomnography (PSG) in the high-altitude city of Bogota, Colombia.A cross-sectional observational study of children with AR was conducted. AR severity was evaluated with ESPRINT-15 questionnaire and ARIA classification. Diagnosis and severity of OSA were established using PSG. Potential associations between AR severity and OSA severity were assessed using binary logistic regression and the Spearman correlation coefficient (?).A total of 99 children, mean age 7.9 years, 45% female, and 53% had OSA. An ESPRINT-15 score was associated with severe OSA (OR 2.0; 95%CI: 1.12-6.04; P= 0.01). Patients with moderate/severe persistent rhinitis according to ARIA exhibited a 10.1-fold greater risk of severe OSA (OR 10.15; CI 1.15 – 89.0). Furthermore, the apnea-hypopnea index was associated with the ESPRINT-15 score (? = 0.215; P=0.03) and with ARIA severity scale (? = 0.203; P=0.04).In AR symptomatic children residing at high altitude, increasing severity of AR is associated with more severe OSA.