A Portable Wireless Urine Detection System with Power-Efficient Electrochemical Readout ASIC and ABTS-CNT Biosensor for UACR Detection.

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This work presents a portable wireless urine detection system which consists of an electrochemical readout application specific integrated circuit (ASIC) and a biosensor composed of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and carbon nanotube (ABTS-CNT) for the detection of urine albumin-to-creatinine ratio (UACR). The ASIC includes a potentiostat, a digital circuitry and a power management circuit which can perform electrochemistry techniques with a dual-channel screen-printing carbon electrode (SPCE). Electrochemical experiments on the proposed biosensor (SPCE|ABTS-CNT|Nafion) have revealed promising sensing characteristics for creatinine and human serum albumin detection. Practical urine tests has demonstrated the capability of the proposed urine detection system for UACR detection with both the power-efficient readout ASIC and the ABTS-CNT biosensor. A user-friendly prototype has also been designed which can be useful for either personal health administration or homecare.

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Authors: Shuenn-Yuh Lee, Hao-Yun Lee, Ding-Siang Ciou, Zhan-Xian Liao, Peng-Wei Huang, Yi-Ting Hsieh, Yi-Chieh Wei, Chia-Yu Lin, Meng-Dar Shieh, Ju-Yi Chen