Latest articles

Signposting the latest clinical articles from the leading medical journals.

The wider, wiser view.

Cardiology

Physical activity and atrial fibrillation risk: it’s complicated; and sex is critical.
Click here to read the full article @ European heart journal
The paclitaxel story in cardiovascular medicine.
Click here to read the full article @ European heart journal
Comparison of Long-Term Outcomes of Patients Having Surgical Aortic Valve Replacement With Versus Without Simultaneous Coronary Artery Bypass Grafting.
Coronary artery disease is a common co-morbidity of aortic stenosis. When needed, …
Advanced imaging for risk stratification of sudden death in hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac condition, which typically manifests …

Dermatology


Emergency Medicine

History of appendectomy? An atypical case of recurrent abdominal pain.
Acute appendicitis is a common condition emergency physician encounter during pediatric emergency …
Clinical factors associated with intubation in the high flow nasal cannula era.
Bronchiolitis is the most common cause for hospitalization in infants. While the …
Evaluation of the Ottawa 3DY as a screening tool for cognitive impairment in older emergency department patients.
This study sought to evaluate the implementation of the Ottawa 3DY Tool, …
Decision fatigue in the Emergency Department: How does emergency physician decision making change over an eight-hour shift?
We examined emergency physician disposition decisions and computed tomography (CT) ordering as …

Endocrinology

Gestational diabetes risk in migrants. A nation-wide register-based study of all births in Denmark 2004-2015.
Much remains to be understood about socio-economic position and body mass index …
Revisiting classical 3β-hydroxysteroid dehydrogenase 2 deficiency: lessons from 31 pediatric cases.
The clinical effects of classical 3β-hydroxysteroid dehydrogenase 2 (3βHSD2) deficiency are insufficiently …

Gastroenterology & Hepatology

Contained Aortic Rupture With Hematoma and Gastrointestinal Bleeding.
Click here to read the full article @ Clinical gastroenterology and hepatology …
First- and Second-line Pharmacotherapies for Patients with Moderate to Severely Active Ulcerative Colitis: An Updated Network Meta-Analysis.
We compared the efficacy and safety of different first-line (biologic-naïve) and second-line …
DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.
Intestinal metaplasia (IM) is a premalignant stage that poses a greater risk …

Haematology

HLA-DRB1*11 is a strong risk factor for acquired thrombotic thrombocytopenic purpura in children.
Click here to read the full article @ Haematologica
Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis.
Allogeneic hematopoietic stem cell transplantation is the treatment of choice for autosomal …
Acetylsalicylic acid (ASA) inhibits intravascular coagulation during S. aureus-induced sepsis in mice.
Anti-platelet therapies have been proposed for the treatment of sepsis, a syndrome …

Neurology

White matter and cerebellar involvement in alternating hemiplegia of childhood.
To determine whether brain volumetric and white matter microstructural changes are present …
Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage.
After aneurysmal subarachnoid haemorrhage (aSAH), extracellular haemoglobin (Hb) in the subarachnoid space …
Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes.
Amyotrophic lateral sclerosis (ALS) is a complex disease with numerous pathological mechanisms …
Hyper-reflexia in Guillain-Barré syndrome: systematic review.
Areflexia or hyporeflexia is a mandatory clinical criterion for the diagnosis of …

Obstetrics & Gynaecology

Experience with same-day placement of the 52mg levonorgestrel-releasing intrauterine system.
Prescribing information for the levonorgestrel-releasing intrauterine system allows placement when the clinician …
A couple-focused, integrated unplanned pregnancy and HIV prevention program in urban and rural Zambia.
Zambia's total fertility rate (5 births per woman) and adult HIV prevalence …
Between Scylla and Charybdis: Delivery in the setting of obstructed labour.
In the article by Ngongo et al in this issue of BJOG …
A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants.
High-dose erythropoietin has been shown to have a neuroprotective effect in preclinical …

Oncology


Paediatrics

The Cinderella van: runaways, street youth and public health in 1970s Boston.
Click here to read the full article @ Archives of disease in …
Intimate partner violence and childhood illnesses in Cambodia: a cross-sectional study.
Around a quarter of Cambodian women reported being victim to intimate partner …
Cleidocranial dysplasia with growth hormone deficiency: a case report.
Cleidocranial dysplasia (CCD) is a rare skeletal disorder with autosomal dominant inheritance …

Psychiatry

Evidence for efficacy of psychosocial interventions in LMICs.
Click here to read the full article @ The lancet. Psychiatry
Efficacy of psychosocial interventions for mental health outcomes in low-income and middle-income countries: an umbrella review.
Mental health conditions are leading causes of disability worldwide. Psychosocial interventions for …
Direction of the relationship between methamphetamine use and positive psychotic symptoms in regular methamphetamine users: evidence from a prospective cohort study.
Methamphetamine has been consistently associated with positive psychotic symptoms, but little is …
Commentary on “Bosch-Boonstra-Schaaf Optic Atrophy Syndrome Presenting as New-Onset Psychosis in a 32-Year-Old Man: A Case Report and Literature Review”.
Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) is a recently described autosomal dominant disorder …

Respiratory

Transcriptional biomarkers for predicting development of TB: progress and clinical considerations.
Achieving the ambitious targets for global tuberculosis (TB) control, will require an …
Clinical utility of fractional exhaled nitric oxide (FeNO) in severe asthma management.
Asthma is a chronic inflammatory disease of the airways, affecting over 350 …
Culture of Pulmonary Arterial Endothelial Cells from Pulmonary Artery Catheter Balloon Tips: Considerations for Use in Pulmonary Vascular Disease.
Endothelial dysfunction is a hallmark of pulmonary arterial hypertension (PAH) but there …
Gefapixant in two randomised dose-escalation studies in chronic cough.
Gefapixant has previously demonstrated efficacy in the treatment refractory chronic cough at …

Rheumatology

A reverse translational study on the effect of rituximab, rituximab plus belimumab, or bortezomib on the humoral autoimmune response in SLE.
SLE is a severe autoimmune disease characterized by autoreactive B cells and IC …
Long-term efficacy and safety of tocilizumab in refractory Takayasu arteritis: final results of the randomized controlled phase 3 TAKT study.
To investigate the long-term efficacy and safety of the IL-6 receptor antibody …
IL-17A and IL-17F expression and functional responses in rheumatoid arthritis and peripheral spondyloarthritis.
Targeting the IL-17-axis is efficacious in psoriasis (PsO) and spondyloarthritis (SpA) but …
A multicentre study of 244 pregnancies in undifferentiated connective tissue disease: maternal/fetal outcomes and disease evolution.
To investigate fetal/perinatal and maternal outcomes from a large multicentre cohort of …

Urology

Outcomes and Risk Factors of Revision and Replacement Artificial Urinary Sphincter Implantation in Radiated and Non-radiated Patients.
Risk factors for complications after artificial urinary sphincter surgery include a history …
Additional Surgeries after Bladder Augmentation in Patients with Spina Bifida in the 21st Century.
To determine long-term risks of additional surgery after augmentation in a modern …
Telemedicine for Pediatric Urologic Postoperative Care is Safe, Convenient and Economical.
We sought to compare virtual visits, remote patient encounters via a live …
Effect of a Behavioral Intervention to Increase Vegetable Consumption on Cancer Progression Among Men With Early-Stage Prostate Cancer: The MEAL Randomized Clinical Trial.
Guidelines endorsing vegetable-enriched diets to improve outcomes for prostate cancer survivors are …