Latest Clinical Articles

A selection of the latest clinical articles from leading peer-reviewed medical journals. You can tailor the feed by selecting your specialty / sub-specialty in the menu above.

• A prolonged course of COVID-19 in a person with dementia.20th October 2020
  The course of COVID-19 may be particularly long-lasting in elderly patients. Caring for patients with dementia suffering from COVID-19 is challenging due to unclear symptom presentation, delirium, and maintaining isolation procedures.A man in his sixties with […]
• Galectin-1 Production is Elevated in Hypertrophic Scar.19th October 2020
  Upon healing, burn wounds often leave hypertrophic scars (HTSs) marked by excess collagen deposition, dermal and epidermal thickening, hypervascularity, and an increased density of fibroblasts. The Galectins, a family of lectins with a conserved carbohydrate […]
• Analyzing Factors Affecting Quality of Life in Patients Hospitalized with Chronic Wound.19th October 2020
  Studies have reported associations between health-related quality of life(HRQOL), social support, and mental stress of patients with chronic wound, while the causal relationship is unclear and little is known about the HRQOL of hospitalized them. […]
• Preoperative Planning for EndoAnchor Use During Thoracic Endovascular Aortic Repair in the Distal Aortic Arch.19th October 2020
  To describe steps related to intraoperative C-arm orientations that can be taken during preoperative planning of thoracic stent-graft repair to facilitate the deployment of EndoAnchors in the distal aortic arch.Previous experience from transcatheter aortic valve […]
• Relationship Between Serum Eicosapentaenoic Acid to Arachidonic Acid Ratio and Atherosclerotic Risk Factors in Patients With Peripheral Artery Disease.19th October 2020
  Background: The eicosapentaenoic acid to arachidonic acid ratio (EPA/AA) is attracting attention as a risk factor for peripheral artery disease (PAD). However, there have been few studies investigating the relationship between the EPA/AA ratio and […]
• Association between coronary artery bypass graft center volume and year-to-year outcome variability: New York and California statewide analysis.19th October 2020
  We evaluated whether volume-based, rather than time-based, annual reporting of center outcomes for coronary artery bypass grafting may improve inference of quality, assuming that large center-level year-to-year outcome variability is related to statistical noise.We analyzed […]
• The impact of HLA-DR mismatch status on retransplant-free survival and bronchiolitis obliterans syndrome‒free survival among sensitized lung transplant recipients.19th October 2020
  Donor‒recipient HLA-DR locus matching may be protective against bronchiolitis obliterans syndrome (BOS) in lung transplant recipients. It is unknown whether this benefit is more significant among sensitized (calculated panel reactive antibodies (CPRAs) of >0%) and […]
• Prophylactic vaccination with a live-attenuated herpes zoster vaccine in lung transplant candidates.19th October 2020
  Herpes zoster (HZ) is caused by the reactivation of varicella-zoster virus (VZV). Patients with lung transplants are at high risk for HZ owing to their immunocompromised status and the need for lifelong immunosuppression. In this […]
• Effects of Short-Duration Ethanol Dehydration on Mechanical Properties of Porcine Pericardium.19th October 2020
  Autologous pericardium is an ideal material for cardiovascular reconstruction including pulmonary artery plasty. Despite the fact that dehydration by ethanol has been used to improve its surgical handling, the effects of the ethanol on mechanical […]
• Resection of Pulmonary Metastases 12 Years after Initial Surgery for a Benign Pheochromocytoma.19th October 2020
  We describe a rare case of newly discovered pulmonary metastases and surgical confirmation 12 years after initial surgery for a pheochromocytoma. A 61-year-old asymptomatic man was referred because of an abnormal shadow in the right […]
• Evidence-based diagnostic accuracy measurement in urine cytology using likelihood ratios.19th October 2020
  Recent cytology classification systems have become more evidence-based and advocate for the use of risk of malignancy (ROM) as a measure of test performance. From the statistical viewpoint, ROM represents the post-test probability of malignancy, […]
• Building regional anesthesia capacity in limited-resource settings: a pilot study evaluating a 4-week curriculum.19th October 2020
  Aim: To pilot a 4-week regional anesthesia curriculum for limited-resource settings. Intervention: A baseline needs assessment and knowledge test were deployed. The curriculum included lectures and hands-on teaching, followed by knowledge attainment tests. Results: Scores […]
• Ultrasound-guided anterior and posterior quadratus lumborum block for analgesia after laparoscopic hysterectomy.19th October 2020
  Aim: Laparoscopic procedures are now preferred over open surgeries, and total laparoscopic hysterectomy is becoming increasingly popular. Quadratus lumborum (QL) block is an evolving technique for abdominal surgeries that blocks T5-L1 nerve branches. Methods: We […]
• Chronic non-cancer pain and its association with healthcare use and costs among individuals with obstructive sleep apnea.19th October 2020
  Aim: To evaluate the impact of chronic non-cancer pain (CNCP) on healthcare use and costs among individuals diagnosed with obstructive sleep apnea (OSA). Materials & methods: Using the IQVIA PharMetrics® Plus database, we identified individuals (18-64 years old) during […]
• Botulinum toxin injections for shoulder and upper limb pain: a narrative review.19th October 2020
  Botulinum toxin (BoNT) has been widely employed to treat poststroke spasticity, cervical dystonia and muscle hyperactivity. Recently, BoNT injections are increasingly used in treating musculoskeletal pain. The mechanism of BoNT in pain relief comprises relaxation […]
• Effects of physical exercise on low back pain and cortisol levels: a systematic review with meta-analysis of randomized controlled trials.19th October 2020
  Aim: To verify the effects of physical exercise on low back pain (LBP) and serum cortisol levels in individuals with chronic LBP. Materials & methods: Randomized controlled trials evaluating the effects of exercise on LBP perception […]
• Evaluation of facial electromyographic pain responses in healthy participants.19th October 2020
  Aim: Assessing pain perception through self-reports may not be possible in some patients, for example, sedated. Our group considered if facial electromyography (fEMG) could provide a useful alternative, by testing on healthy participants subjected to […]
• Outcomes of Venous End-to-Side Microvascular Anastomoses of the Head and Neck.19th October 2020
  The literature on outcomes of end-to-side (ETS) anastomoses for microvascular reconstruction of the head and neck is limited. This series reviews ETS in free tissue transfer (FTT) across multiple institutions to better understand their usage […]
• Physiologically variable ventilation in a rabbit model of asthma exacerbation.19th October 2020
  Mechanical ventilation during status asthmaticus is challenging and increases the risk of severe complications. We recently reported the value of physiologically variable ventilation (PVV) in healthy and acutely injured lungs. We investigated whether PVV provides […]
• Sources of information in times of health crisis: evidence from Turkey during COVID-19.19th October 2020
  Media as a source of information can shape public opinion regarding the COVID-19 response. Identifying how and where people seek information during the COVID-19 outbreak is vital to convey the most effective message about managing […]
• Early Treatment of COVID-19 Disease: A Missed Opportunity.19th October 2020
  Antivirals have demonstrated efficacy in treating other infectious diseases in early stages of disease, reducing morbidity, mortality, and the likelihood of onward transmission. At the time of writing, more than 1900 clinical trials are registered […]
• Minor covid-19 association with crime in Sweden.19th October 2020
  The covid-19 disease has a large impact on life across the globe, and this could potentially include impacts on crime. The present study describes how crime has changed in Sweden during ten weeks after the […]
• Blockchain for COVID-19: Review, Opportunities, and a Trusted Tracking System.19th October 2020
  The sudden development of the COVID-19 pandemic has exposed the limitations in modern healthcare systems to handle public health emergencies. It is evident that adopting innovative technologies such as blockchain can help in effective planning […]
• Role of Mass Media and Public Health Communications in the COVID-19 Pandemic.19th October 2020
  In Dec 2019, a novel pathogen emerged, and within weeks, led to the emergence of the biggest global health crises seen to date. The virus called ‘SARS-CoV-2’, causes coronavirus disease which was named ‘COVID-19’ by […]
• COVID-19 Modeling in Saudi Arabia Using the Modified Susceptible-Exposed-Infectious-Recovered (SEIR) Model.19th October 2020
  The coronavirus disease 2019 (COVID-19) pandemic has created unprecedented healthcare emergencies across the globe. The World Health Organization (WHO) has proposed social distancing (SD) as a prudent measure to contain the pandemic and, hence, governments […]
• Spontaneous Intraparenchymal Hepatic Hemorrhage as a Sequela of COVID-19.19th October 2020
  Patients with coronavirus disease 2019 (COVID-19) have been presenting with varying signs and symptoms. The medical community is being updated with new knowledge about this disease daily. We present a case of intrahepatic hemorrhage in […]
• Bowel Ischemia in a Patient With SARS CoV-2-Like Illness and Negative Real-Time Reverse Transcription Polymerase Chain Reaction Test Results During the Peak of the Pandemic.19th October 2020
  An 83-year-old man presented to the emergency department (ED) during the peak of the first wave of the SARS CoV-2 (COVID-19) pandemic with severe abdominal pain, mimicking a severe abdominal pathology. He was found to have […]
• Reducing False Negative PCR Test for COVID-19.19th October 2020
  As the SARS-CoV-2 (COVID-19) pandemic spreads rapidly, there is need for a diagnostic test with high accuracy to detect infected individuals especially those without symptoms. Real-time polymerase chain reaction (RT-PCR) is a common molecular test […]
• How to perform and interpret the lung ultrasound by the obstetricians in pregnant women during the SARS-CoV-2 pandemic.19th October 2020
  Evidence for the use of lung ultrasound scan (LUS) examinations in coronavirus 2019 pneumonia is rapidly growing. The safe and non-ionizing nature of LUS drew attention, particularly for pregnant women. This study aimed to contribute […]
• Anxiety levels and obsessive compulsion symptoms of pregnant women during the COVID-19 pandemic.19th October 2020
  Reliable data regarding maternal mental well-being during the Severe Acute Respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic are scarce. This study aimed to assess the state/trait anxiety and obsessive-compulsive symptoms of pregnant women and compare those with […]
• Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances.19th October 2020
  To investigate pregnancy outcomes and compare the clinical characteristics of coronavirus 2019 (COVID-19) disease in pregnant and agematched non-pregnant women.Hospital records of four tertiary care centers were reviewed retrospectively. The subjects comprised 188 pregnant patients […]
• The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications.19th October 2020
  The current pandemic of novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) poses a significant global public health threat. While urgent regulatory measures in control of the rapid spread of this virus are essential, scientists around […]
• Impact of novel coronavirus disease (COVID-19) on Egyptian dentists’ fear and dental practice (a cross-sectional survey).19th October 2020
  This study aimed to evaluate the fear of infection among Egyptian dentists practicing during the current coronavirus disease 2019 (COVID-19) pandemic and to explore the dentist’s knowledge about guidelines to fight the virus and to […]
• Spatiotemporal analysis and hotspots detection of COVID-19 using geographic information system (March and April, 2020).19th October 2020
  Understanding the spatial distribution of coronavirus disease 2019 (COVID-19) cases can provide valuable information to anticipate the world outbreaks and in turn improve public health policies. In this study, the cumulative incidence rate (CIR) and […]
• Knowledge, attitude, practice and psychological response toward COVID-19 among nurses during the COVID-19 outbreak in Northern Ethiopia, 2020.19th October 2020
  Coronavirus disease in 2019 (COVID-19) is not only a deadly outbreak disease but also affects the mental status of the population, including nurses. Nurses play a vital role in dealing with COVID-19 victims. Nurses’ infection […]
• Development of a novel platform of virus-like particle (VLP) based vaccine against coronavirus 2019 (SARS-CoV-2) by exposing of epitopes: an immunoinformatics approach.19th October 2020
  The emergence of a rapidly spreading and highly infectious COVID-19 outbreak by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has caused a global pandemic with unprecedented, social and economic dimensions. Therefore, the […]
• COVID-19 with spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema.19th October 2020
  •Complications such as pneumomediastinum and/or pneumothorax during the course of COVID-19 remain rare and their mechanism is poorly described.•We present a case of COVID-19 pneumonia associated with spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema in an […]
• Report of four pregnant women getting COVID-19 in Ilam, Iran: Case Series.19th October 2020
  Today, COVID-19 has become the most important health burdenall over the world.Pregnant women are determined as one of the high-risk groups. COVID-19 infection in this group may result in huge damages. This study aimed to […]
• Role of micronutrients in the management of COVID-19.19th October 2020
  Micronutrients play an important role in enhancing the immune system, therefore, proper nutritional support of micronutrients could have a positive impact on COVID-19 outcome. View the full article @ New Microbes and New Infections Get […]
• Kinetics and isotype assessment of antibodies targeting the spike protein receptor-binding domain of severe acute respiratory syndrome-coronavirus-2 in COVID-19 patients as a function of age, biological sex and disease severity.19th October 2020
  There is an incomplete understanding of the host humoral immune response to severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2, which underlies COVID-19, during acute infection. Host factors such as age and sex as well as the […]
• Covid-19 pandemic: Economic burden on patients with musculoskeletal injuries in a tertiary care hospital of LMIC; retrospective cross sectional study.19th October 2020
  Covid-19 has adversely impacted the health care organizations by over burdening with Covid patients and suspending the elective surgeries and clinics. Hospitalization during pandemic may increase health cost of patients for elective and emergency procedure […]
• The plight of COVID-19 pandemic on medical students and residency applicants.19th October 2020
  In this pandemic situation, medical students find them in a state of apprehension. With medical institutions closed and switch to online teaching and telehealth, many aspects of medical learning are still compromised, including core clinical […]
• Public health prevention and emergency preparedness funding in the United States: Are we ready for the next pandemic?19th October 2020
  •The CDC’s cumulative funding for Public Health, Prevention, and Emergency Preparedness decreased over the course of 2011-2020, however, NIH funding dedicated to Prevention displayed an overall increase from 2008 to 2019.•The Hospital Preparedness Program (HPP) […]
• COVID-19 in pastoral contexts in the greater Horn of Africa: Implications and recommendations.19th October 2020
  COVID-19 is a global pandemic that continues to spread around the world, including to Africa where cases are steadily increasing. The African Centres for Disease Control and Prevention is leading the pandemic response in Africa, […]
• Enhancing innate immunity against virus in times of COVID-19: trying to untangle facts from fictions.19th October 2020
  In the light of the current COVID-19 pandemic, during which the world is confronted with a new, highly contagious virus that suppresses innate immunity as one of its initial virulence mechanisms, thus escaping from the […]
• Effect of COVID-19 outbreak on urban health and environment.19th October 2020
  The WHO announced coronavirus disease a Public Health Emergency on 30 January 2020, and it spreads across the whole planet. Aftermath of outbreak of this disease at the global level is more frightening and panicking […]
• Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike Protein.19th October 2020
  SARS-CoV-2 is a SARS-like novel coronavirus strain first identified in December 2019 in Wuhan, China. The virus has since spread globally, resulting in the current ongoing coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 spike protein is […]
• Mental Health Disorders During the COVID-19 Outbreak in Cyprus.19th October 2020
  Cyprus has been affected by COVID-19 since March 2019. With a case fatality rate of 2.6% (until June 2020) and the social isolation measures enforced on the population, the population’s mental health has been affected. […]
• MiR-146a rs2910164 G > C polymorphism modulates Notch-1/IL-6 signaling during infection: a possible risk factor for Crohn’s disease.19th October 2020
  MiR-146a, an effector mediator, targets Notch-1 and regulates the innate and adaptive immune systems response. Recently, we reported that Notch-1 signaling plays a key role in macrophage polarization and response during infection. We employed Mycobacterium […]
• Systematic Analyses on the Potential Immune and anti-inflammatory Mechanisms of Shufeng Jiedu Capsule against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-caused Pneumonia.19th October 2020
  The outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-caused pneumonia (Coronavirus disease -19, COVID-19), has resulted in a global health emergency. However, there is no vaccine or effective antiviral treatment against the newly emerged […]
• The practice of cytopathology during the era of COVID-19: challenges and changes.19th October 2020
  This paper reviews the challenges faced by cytology laboratories during the COVID-19 pandemic. Various safety guidelines regarding collection, handling, transport and sampling in cytology laboratory are presented. A brief literature overview of adapted changes regarding […]
• Physical activity moderates the association between parenting stress and quality of life in working mothers during the COVID-19 pandemic.19th October 2020
  Working mothers are a population experiencing heightened levels of parenting stress during the COVID-19 pandemic. The purpose of the current study was to evaluate the associations between parenting stress, quality of life, and physical activity […]
• Designing low-cost, accurate cervical screening strategies that take into account COVID-19: a role for self-sampled HPV typing2.19th October 2020
  We propose an economical cervical screening research and implementation strategy designed to take into account the typically slow natural history of cervical cancer and the severe but hopefully temporary impact of COVID-19. The commentary introduces […]
• Familial Mediterranean Fever and COVID-19: Friends or Foes?19th October 2020
  Familial Mediterranean Fever (FMF) and COVID-19 show a remarkable overlap of clinical symptoms and similar laboratory findings. Both are characterized by fever, abdominal/chest pain, elevation of C-reactive protein, and leukocytosis. In addition, colchicine and IL-1 […]
• Convalescent Plasma: The Relay Baton in the Race for Coronavirus Disease 2019 Treatment.19th October 2020
  Coronavirus disease 2019 (COVID-19) is a pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Most infected people have mild or moderate symptoms and recover without the need for extensive treatment. However, for seriously […]
• Immunopathogenesis of COVID-19: Summary and Possible Interventions.19th October 2020
  Since the onset of the COVID-19 pandemic in the fall of 2019 over 4 million people have been infected and over 280,000 have died (1). Information about the SARS-CoV2 virus is evolving rapidly. At this […]
• Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology.19th October 2020
  Emerging evidence indicates a potential role for monocytes in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, in COVID-19 patients, with the aim of characterizing their potential role in monocyte-macrophage […]
• COVID-19: In the Eye of the Cytokine Storm.19th October 2020
  The dysregulated release of cytokines has been identified as one of the key factors behind poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory and immune response, especially in the lungs, leading to […]
• Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors-The Current Status.19th October 2020
  Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) induced Coronavirus Disease – 19 (COVID-19) cases have been increasing at an alarming rate (7.4 million positive cases as on June 11 2020), causing high mortality (4,17,956 deaths as […]
• Probiotics in Medicine: A Long Debate.19th October 2020
  During the last years probiotics gained the attention of clinicians for their use in the prevention and treatment of multiple diseases. Probiotics main mechanisms of action include enhanced mucosal barrier function, direct antagonism with pathogens, […]

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