Potential Mechanisms of Sodium-Glucose Co-Transporter 2 Inhibitor-Related Cardiovascular Benefits.
The findings of recent clinical trials have shown that sodium-glucose co-transporter 2 …
Characteristics and Outcomes of Patients Treated With Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors (The Mayo Clinic Experience).
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors represent a novel addition to …
Meta-analysis Comparing Combined Use of Eicosapentaenoic Acid and Statin to Statin Alone.
Role of omega-3-Fatty acids, especially eicosapentaenoic acid (EPA), in reducing cardiovascular events …
Relation of Change of Body Mass Index to Long-Term Mortality After Cardiac Catheterization.
Body-mass index (BMI) is a risk marker and therapeutic target in cardiovascular …
Shaping specialist treatment of Stevens-Johnson syndrome/toxic epidermal necrolysis.
Click here to read the full article @ The British journal of …
Differences between acral and nonacral melanoma genomes.
Click here to read the full article @ The British journal of …
Good practice in dermatological patient-reported outcome measure development: an example from localized scleroderma.
Click here to read the full article @ The British journal of …
Development and preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL): a disease-specific measure of quality of life in adolescents with psoriasis.
No age-appropriate and disease-specific instrument currently exists to measure health-related quality of …
Atomized intranasal vs intravenous fentanyl in severe renal colic pain management: A randomized single-blinded clinical trial.
Renal colic is one of the most common painful disorders in patients …
Pseudo-pulseless electrical activity in the emergency department, an evidence based approach.
A great deal of the literature has focused specifically on true pulseless …
Barriers to breastfeeding for emergency medicine physicians in the emergency department.
Click here to read the full article @ The American journal of …
Treating Opioid Withdrawal With Buprenorphine in a Community Hospital Emergency Department: An Outreach Program.
We assess the feasibility of using our community hospital emergency department (ED) …
Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes.
Diabetic peripheral neuropathy (DPN) is one of the major complications of diabetes, …
Diagnostic testing for Graves’ or non-Graves’ hyperthyroidism: a comparison of two thyrotropin receptor antibody immunoassays with thyroid scintigraphy and ultrasonography.
Graves' disease (GD) is the most common cause of hyperthyroidism. In many …
Outcomes of patients with Nelson’s syndrome after primary treatment: a multicenter study from 13 UK Pituitary centers.
Long-term outcomes of patients with Nelson's syndrome (NS) have been poorly explored, …
Dynamic pituitary-adrenal interactions in the critically ill after cardiac surgery.
Patients with critical illness are thought to be at risk of adrenal …
Complete Endoscopic Healing Associated With Better Outcomes Than Partial Endoscopic Healing in Patients With Crohn’s Disease.
Mucosal healing (MH) has been associated with a good outcomes of patients …
A schistosome miRNA promotes host hepatic fibrosis by targeting transforming growth factor beta receptor III.
MiRNAs derived from pathogens, and even plants have been detected in body …
Alcohol Use is Associated with Hepatic Steatosis Among Persons with Presumed Non-alcoholic Fatty Liver Disease.
Many individuals presumed to have non-alcoholic fatty liver disease (NAFLD) consume moderate …
Educate, Test and Treat Model towards elimination of hepatitis C infection in Egypt: Feasibility and effectiveness in 73 villages.
Egypt has one of the highest burdens of HCV infection worldwide, and …
Chronic Myelomonocytic Leukemia: 2020 Update on Diagnosis, Risk Stratification and Management.
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder with …
Randomized Multicenter Trial of Sirolimus vs. Prednisone as Initial Therapy for Standard Risk Acute GVHD: BMT CTN 1501.
Clinical- and biomarker-based tools may identify a lower risk acute graft-versus-host disease …
Gain-of-function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway.
Dehydrated hereditary stomatocytosis (DHS), or xerocytosis, is an autosomal dominant hemolytic anemia. …
IRF4-rearranged Large B-cell lymphoma (LBCL) has a genomic profile distinct to other LBCL in children and young adults.
Pediatric large B-cell lymphomas (LBCL) share morphological and phenotypic features with adult …
Cerebrospinal fluid total protein in Guillain-Barré syndrome variants: correlations with clinical category, severity, and electrophysiology.
The discriminative value of CSF total protein (CSF-TP) in subtypes of Guillain-Barré …
Sensitivity and specificity of single-fibre EMG in the diagnosis of ocular myasthenia varies accordingly to clinical presentation.
Single-fibre electromyography (SF-EMG) is considered as the most sensitive test for the …
Cenobamate: new hope for treatment-resistant epilepsy.
Abstract empty Click here to read the full article @ The Lancet. …
Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.
More than a third of patients with epilepsy are treatment resistant, and …
Training medical students in communication; A shared responsibility.
In the UK, Medical Schools are required by the General Medical Council …
Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2.
Decidualization defects in the endometrium have been demonstrated at the time of …
Analgesic use at ovulation and implantation and human fertility.
Studies investigating the effects of pain-relieving medication use on conceiving a pregnancy …
THE COMPETING RISK APPROACH FOR PREDICTION OF PREECLAMPSIA.
The established method of assessing the risk for development of preeclampsia (PE) …
TRK inhibitors in TRK fusion-positive cancers.
TRK fusions are oncogenic drivers of various adult and paediatric cancers. The …
Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study.
Precision medicine trials in glioblastoma (GBM) are often conducted at tumor recurrence. …
Identifying patients with NTRK fusion cancer.
Due to the efficacy of tropomyosin receptor kinase (TRK) inhibitor therapy and …
Rapid, complete and sustained tumour response to the TRK inhibitor larotrectinib in an infant with recurrent, chemotherapy-refractory infantile fibrosarcoma carrying the characteristic ETV6-NTRK3 gene fusion.
The ETV6-NTRK3 gene fusion is present in the majority of cases of …
Nutrient intakes and sources of fiber among children with low and high dietary fiber intake: the 2016 feeding infants and toddlers study (FITS), a cross-sectional survey.
Increasing dietary fiber intake in children may improve overall diet quality. The …
Safety of the 9-Valent Human Papillomavirus Vaccine.
The 9-valent human papillomavirus vaccine (9vHPV) was approved for females and males …
Randomised controlled trial of an intervention to improve parental knowledge and management practices of fever.
We know that parents require resources which can assist them to improve …
From Peyton Rous to the HPV Vaccine: A Journey of Discovery and Progress.
Click here to read the full article @ Pediatrics
Unsystematic review shows neither that early intervention in psychosis is cost-effective nor cost-minimising.
Click here to read the full article @ The British journal of …
School-based interventions to prevent anxiety and depression in children and young people: a systematic review and network meta-analysis.
Rates of anxiety and depression are increasing among children and young people. …
Prevention versus intervention in school mental health.
Abstract empty Click here to read the full article @ The lancet. …
Functional cognitive disorders: a systematic review.
Cognitive symptoms are common, and yet many who seek help for cognitive …
American Thoracic Society calls for more research into military deployment respiratory exposures.
Click here to read the full article @ The Lancet. Respiratory medicine
Results of an Expert Consensus Survey on the Treatment of Pulmonary Arterial Hypertension with Oral Prostacyclin Pathway Agents.
Treatment of pulmonary arterial hypertension (PAH) has evolved substantially over the past …
US States confront oil and gas drilling health hazards.
Click here to read the full article @ The Lancet. Respiratory medicine
Acute ventilatory support during whole-body hybrid rowing in patients with high-level spinal cord injury: a randomized controlled cross-over trial.
High-level spinal cord injury (SCI) results in profound spinal and supraspinal deficits, …
Novel associations between cytokines and pulmonary involvement in juvenile dermatomyositis – a cross-sectional study of long-term disease.
To examine associations between cytokines and pulmonary involvement in patients with medium- …
Association between depression and rheumatoid arthritis: two longitudinal follow-up studies using a national sample cohort.
To investigate the bidirectional relation between RA and depression.Data from the Korean …
The clinical and economic burden of systemic sclerosis related interstitial lung disease.
To quantify the burden of interstitial lung disease (ILD) in SSc.Clinical data …
Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study.
To investigate potential subgroups of primary care-diagnosed patients with PMR based on …
Long-term Oncological Outcomes from an Early Phase Randomised Controlled Three-arm Trial of Open, Robotic, and Laparoscopic Radical Cystectomy (CORAL).
The long-term oncological outcomes of laparoscopic (LRC) and robotic-assisted radical cystectomy (RARC) …
Transcriptome Analysis to Identify Human Spermatogonial Cells from Sertoli Cell Only Testes.
To determine whether gene products from spermatogenic cells can be detected in …
Cost Effectiveness of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: Results of the ROSETTA Randomized Trial.
Sacral neuromodulation and intradetrusor injection of onabotulinumtoxinA are therapies for refractory urgency-urinary …
A Randomized, Double-Blinded, Control Trial Shows that Onabotulinum Toxin a (Botox®) Nerve Blocks Do Not Provide Improved Pain Control for Men with Chronic Scrotal Pain.
The use of Onabotulinum Toxin A (BTX) to chemically denervate the testis …
