Latest articles

Signposting the latest clinical articles from the leading medical journals.

The wider, wiser view.

Cardiology

Development and validation of a cardiovascular risk score for patients in the community after acute coronary syndrome.
Following acute coronary syndrome (ACS), patients are managed long-term in the community, …
Inline perfusion mapping provides insights into the disease mechanism in hypertrophic cardiomyopathy.
In patients with hypertrophic cardiomyopathy (HCM), the role of small vessel disease …
Sickle cell disease: at the crossroads of pulmonary hypertension and diastolic heart failure.
Sickle cell disease (SCD) is caused by a single point mutation in …
Valve regurgitation in patients surviving endocarditis and the subsequent risk of heart failure.
Significant valve regurgitation is common in patients surviving native valve infective endocarditis …

Dermatology

Disposable syringe punching: An aseptic alternative to a comedone extractor.
Click here to read the full article @ Journal of the American …
Surgical marking pen improving nail pitting visualization.
Click here to read the full article @ Journal of the American …
Interdigital injection of botulinum toxin for patients with Raynaud’s phenomenon.
Click here to read the full article @ Journal of the American …
Regulations, Liability, Safety, and Economics Related to Compounding.
Extemporaneous compounding is a means to tailor a medication to an individual …

Emergency Medicine

Primary Care Screening for Abdominal Aortic Aneurysm: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Ruptured abdominal aortic aneurysms (AAAs) have mortality estimated at 81%.To systematically review …
“Robo-tripping”: Dextromethorphan toxicity and abuse.
Click here to read the full article @ The American journal of …
In-Situ simulation for enhancing teamwork in the emergency department.
Click here to read the full article @ The American journal of …

Endocrinology

Low high-density lipoprotein cholesterol to monitor long-term average increased triglycerides.
Increased triglyceride-rich remnants represent a causal risk factor for ischemic cardiovascular disease.We …
P450 oxidoreductase deficiency: A systematic review and meta-analysis of genotypes, phenotypes and their relationships.
P450 oxidoreductase deficiency (PORD) is a rare genetic disorder that is associated …

Gastroenterology & Hepatology

USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis.
Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). …
Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.
To provide an understanding of the role of common genetic variations in …

Haematology

Impact of NPM1/FLT3-ITD genotypes defined by the2017 European LeukemiaNet in patients with acute myeloid leukemia.
Patients with AML harboring FLT3 internal tandem duplications (ITD) have poor outcomes, …
Is There an Optimal Conditioning for Older Patients with AML Receiving Allogeneic Hematopoietic Cell Transplantation?
The optimal conditioning regimen for older patients with AML remains unclear. Here …
Lack of the multidrug transporter MRP4/ABCC4 defines the PEL-negative blood group and impairs platelet aggregation.
The rare PEL-negative phenotype is one of the last blood groups with …
Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.
Vitamin D deficiency is a common, potentially reversible contributor to morbidity and …

Neurology

Pelvic plexiform neurofibromatosis presenting with genital numbness.
Click here to read the full article @ Practical neurology
New routes of dopaminergic drug delivery in patients with Parkinson’s disease.
Click here to read the full article @ The Lancet. Neurology
Apomorphine sublingual film for off episodes in Parkinson’s disease: a randomised, double-blind, placebo-controlled phase 3 study.
Many patients with Parkinson's disease have potentially disabling off episodes that are …
Cerebrospinal fluid-based metabolomics to characterize different types of brain tumors.
Brain tumors cause significant morbidity and mortality due to rapid progression and …

Obstetrics & Gynaecology

Cervicovaginal microbial communities deficient in Lactobacillus species are associated with second trimester short cervix.
The cervix functions as a barrier to ascending pathogens in pregnancy. Short …
NON- OPIOID VERSUS OPIOID ANALGESIA AFTER HOSPITAL DISCHARGE FOLLOWING CESAREAN DELIVERY: A RANDOMIZED EQUIVALENCE TRIAL.
To determine whether pain score after cesarean delivery is equivalent among women …
Considering Changes in the Recommended Human Chorionic Gonadotropin Monitoring After Molar Evacuation.
Click here to read the full article @ Obstetrics and gynecology
Postpartum Readmissions Among Women With Diabetes.
To estimate whether women with diabetes are at risk for 60-day postpartum …

Oncology

Osimertinib for Patients With Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Multicenter, Open-Label, Phase II Trial (KCSG-LU15-09).
Approximately 10% of patients with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell …
Outcome in Children With Standard-Risk B-Cell Acute Lymphoblastic Leukemia: Results of Children’s Oncology Group Trial AALL0331.
Children's Oncology Group (COG) AALL0331 tested whether intensified postinduction therapy that improves …
Overall Survival with Ribociclib plus Fulvestrant in Advanced Breast Cancer.
In an earlier analysis of this phase 3 trial, ribociclib plus fulvestrant …
Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer.
Patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer …

Paediatrics

Handwriting in children with Attention Deficient Hyperactive Disorder: role of graphology.
Handwriting difficulties are common in children with attention deficient hyperactive disorder (ADHD). …
Global Health Experience and Interest: Results From the AAP Periodic Survey.
Interest and participation in global health (GH) experiences have increased over the …
Analysis of factors related to recurrence of paediatric hepatoblastoma – a single Centre retrospective study.
This study was performed to identify risk factors associated with recurrence of …
Sudden Unexplained Infant Deaths and Day of Life.
Click here to read the full article @ Pediatrics

Psychiatry

Motives for Illicit Drug Use Among Individuals With Body Dysmorphic Disorder.
Drug use disorders (DUDs) are highly prevalent in body dysmorphic disorder (BDD), …
Categorizing Cannabis and Alcohol Use Patterns of Emerging Adults in Psychiatric Partial Hospitalization Treatment.
Emerging adulthood is a common and problematic time for alcohol and cannabis …
Psychological Function, Iyengar Yoga, and Coherent Breathing: A Randomized Controlled Dosing Study.
Evidence suggests that yoga may be an effective treatment for major depressive …

Respiratory

County-Level Variations in Receipt of Surgery for Early-Stage Non-small Cell Lung Cancer in the United States.
Although counties are the smallest geographic level for comprehensive health-care delivery analysis, …
A 38-Year-Old Man With An Ataxic Gait, Night Sweats, and Weight Loss.
A 38-year-old Jamaican man with no medical history presented with worsening right-sided …
A 60-Year-Old Man With Right Lung Mass Presents With Cough.
A 60-year-old Chinese man was admitted to our hospital with chronic cough …
A 65-Year-Old Man with Pulmonary Opacities and Worsening Cough.
A 65-year-old man was referred for evaluation of several years of chest …

Rheumatology

A case of fatal, relapsing GCA following one year of tocilizumab.
Click here to read the full article @ Rheumatology (Oxford, England)
Ossification of the ligamentum flavum.
Click here to read the full article @ Rheumatology (Oxford, England)
Against the dryness-an innovative 3D acini model to test new drugs in primary Sjögren’s syndrome.
Click here to read the full article @ Rheumatology (Oxford, England)
Response to: ‘NCF1-339 polymorphism and systemic lupus erythematosus’ by Joob and Wiwanitkit.
Click here to read the full article @ Annals of the rheumatic …

Urology

The Balance Between Open and Robotic Training Among Graduating Urology Residents: Does Surgical Technique Need Monitoring?
A minimum number of index procedures are required for graduation. Without thresholds …
The MRI in Active Surveillance “MRIAS” Trial: Use of Baseline mpMRI and Saturation Biopsy to Reduce the Frequency of Surveillance Prostate Biopsies.
Prospective studies are lacking in assessing: (i) The diagnostic utility of serial …
Clinicopathological and Survival Analysis of Clinically Advanced Papillary and Chromophobe Renal Cell Carcinoma.
Click here to read the full article @ The Journal of Urology