Latest articles

Signposting the latest clinical articles from the leading medical journals.

The wider, wiser view.

Cardiology

Novel Anatomic Predictors of New Persistent Left Bundle Branch Block After Evolut Transcatheter Aortic Valve Implantation.
New persistent left bundle branch block (NP-LBBB) has been associated with adverse …
Pet Ownership and Cardiovascular Health in the US General Population.
The 2013 American Heart Association Scientific Statement on pet ownership and cardiovascular …
Presentation, Treatment, and Outcome of Survivors of In-Hospital Versus Out-of-Hospital Sudden Cardiac Arrest.
We examined the baseline characteristics, rates of implantable cardioverter defibrillator implantation, and …

Dermatology

Urothelial carcinoma initially presenting as vulvodynia.
Click here to read the full article @ Clinical and experimental dermatology …
Molecular basis and inheritance patterns of amyloidosis cutis dyschromica.
Click here to read the full article @ Clinical and experimental dermatology …
Integrated Safety Analysis: Frequency of Urinary Tract Infections in Patients with Psoriasis Treated with Ixekizumab.
Click here to read the full article @ Journal of the American …

Emergency Medicine

Hemodynamic response of restoring sinus rhythm in critically ill patients with atrial fibrillation.
Electrical cardioversion (ECV) is the recommended treatment for atrial fibrillation (AFib) in …
Electrical cardioversion for atrial fibrillation in the emergency department: A large single-center experience.
Electrical cardioversion of ED patients is a well-described treatment strategy for certain …
The impact of helicopter emergency medical service on acute ischemic stroke patients: A systematic review.
Helicopter emergency medical services (HEMS) is commonly elected transport for acute ischemic …
QTc, Tp-e interval and Tp-e/QTc ratio in patients with nontraumatic subarachnoid hemorrhage.
Click here to read the full article @ The American journal of …

Endocrinology

A randomized controlled trial of a lifestyle intervention with longitudinal follow up on ovarian dysmorphology in women with polycystic ovary syndrome.
Effects of lifestyle modification on reproductive function in polycystic ovary syndrome (PCOS) …
Low signal intensities of MRI T1 mapping predict refractory diplopia in Graves’ ophthalmopathy.
In Graves' ophthalmopathy (GO), fibrosis in extraocular muscles (EOMs) may be related …
Effect of maternal smoking during pregnancy on childhood type 1 diabetes: a whole-of-population study.
Evidence of an association between maternal smoking during pregnancy (prenatal smoking) and …
Vasomotor symptoms and accelerated epigenetic aging in the Women’s Health Initiative (WHI).
The hallmark menopausal symptom, vasomotor symptoms (VMS), has been linked to adverse …

Gastroenterology & Hepatology

Hepatic manifestations of cystic fibrosis.
Liver disease in cystic fibrosis (CF) usually develops before puberty, is often …
The utility of liver biopsy in 2020.
Over the past decade, imaging modalities and serological tests have emerged as …
Tyrosine Kinase Inhibitor-induced Colitis as A Rare Cause of Bloody Diarrhea.
Click here to read the full article @ Clinical gastroenterology and hepatology …
Effects of Colesevelam on Bowel Symptoms, Biomarkers, and Colonic Mucosal Gene Expression in Patients with Bile Acid Diarrhea in a Randomized Trial.
Approximately one-third of patients with IBS-diarrhea (IBS-D) have increased bile acid (BA) …

Haematology

Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for Acute Myeloid Leukemia cell proliferation.
Non-coding RNAs including small nucleolar RNAs (snoRNAs) play important roles in leukemogenesis …
Prognostic factors for VTE and Bleeding in Hospitalized Medical Patients: a systematic review and meta-analysis.
Many predictors for venous thromboembolism (VTE) and bleeding in hospitalized medical patients …
Iron deficiency induced thrombocytosis increases thrombotic tendency in rats.
Iron deficiency (ID) is globally prevalent, and apart from anemia is associated …

Neurology

Challenges to stroke care 5 years after endovascular therapy became the standard.
Click here to read the full article @ The Lancet. Neurology
Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial.
S44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of …
Brain iron deposition is linked with cognitive severity in Parkinson’s disease.
Dementia is common in Parkinson's disease (PD) but measures that track cognitive …
Differential response to pallidal deep brain stimulation among monogenic dystonias: systematic review and meta-analysis.
Genetic subtypes of dystonia may respond differentially to deep brain stimulation of …

Obstetrics & Gynaecology

Is there any move to use metformin for endometrial hyperplasia in routine clinical practice?
One-week after the study by Bing-yi Yang and colleagues from the University …
Enhanced Recovery After Surgery Outcomes in Minimally Invasive Non-Hysterectomy Gynecologic Procedures.
Improved patient outcomes and satisfaction associated with enhanced recovery after surgery protocols …
Evaluation of an external fetal electrocardiogram monitoring system: A randomized controlled trial.
To compare interpretability of two intrapartum abdominal fetal heart rate monitoring strategies. …
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Click here to read the full article @ Obstetrics and gynecology

Oncology

Phase Ib/II Clinical Trial of Pembrolizumab With Bevacizumab for Metastatic Renal Cell Carcinoma: BTCRC-GU14-003.
We hypothesized that bevacizumab will potentiate activity of pembrolizumab. We conducted a …
Lurbinectedin as second- or third-line palliative therapy in malignant pleural mesothelioma: an international, multi-centre, single-arm, phase II trial (SAKK 17/16).
Systemic second- and third-line therapies for malignant pleural mesothelioma (MPM) result in …

Paediatrics

Oximetry-detected pulsus paradoxus predicts for severity in paediatric asthma.
To evaluate if qualitative visual detection of pulsus paradoxus (PP) on the …
Screening for infection in unaccompanied asylum-seeking children and young people.
We aimed to evaluate a screening programme for infection in unaccompanied asylum …
Distribution characteristics of cow’s milk-sIgE components in children with respiratory allergic diseases in southern China.
Cow's milk (CM) is the main food allergen for toddlers and infants. …
Maternal Alcohol-Use Disorder and Child Outcomes.
Investigate the relationship between maternal alcohol-use disorder and multiple biological and social …

Psychiatry

Psychotherapy Patients of Psychiatry Residents: A Descriptive Study.
Psychiatry residents learn psychodynamic psychotherapy for generalizable skills and as a transdiagnostic, …
Associations between life-course-persistent antisocial behaviour and brain structure in a population-representative longitudinal birth cohort.
Studies with behavioural and neuropsychological tests have supported the developmental taxonomy theory …
The ubiquitin proteasome system and schizophrenia.
The ubiquitin-proteasome system is a master regulator of neural development and the …
Depressive symptoms and objectively measured physical activity and sedentary behaviour throughout adolescence: a prospective cohort study.
Identifying modifiable risk factors is essential to reduce the prevalence adolescent depression. …

Respiratory

Prospective community programme versus parent-drive care to prevent respiratory morbidity in children following hospitalisation with severe bronchiolitis or pneumonia.
Hospitalisation with severe lower respiratory tract infection (LRTI) in early childhood is …
Diagnosis of EVALI: General Approach and the Role of Bronchoscopy.
A 23 year-old man arrives at the emergency department with a three …
‘HIGH RISK’ CLINICAL AND INFLAMMATORY CLUSTERS IN COPD OF CHINESE DESCENT.
COPD is a heterogeneous disease demonstrating inter-individual variation. A high COPD prevalence …
The Association between Air Pollution and Hospitalization of Patients with Idiopathic Pulmonary Fibrosis in Chile: A daily time series analysis.
Idiopathic pulmonary fibrosis (IPF) causes progressive dyspnea, hypoxemia and death within a …

Rheumatology

Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling.
Syndecan-4 (sdc4) is a cell-anchored proteoglycan that consists of a transmembrane core …
Is treat-to-target really working in rheumatoid arthritis? a longitudinal analysis of a cohort of patients treated in daily practice (RA BIODAM).
To investigate whether following a treat-to-target (T2T)-strategy in daily clinical practice leads …
Predictors of presenteeism, absenteeism and job loss in patients commencing methotrexate or biologic therapy for rheumatoid arthritis.
Work is an important health outcome. This study aimed to identify predictors …

Urology

Testosterone Breakthrough Rates during Androgen Deprivation Therapy for Castration Sensitive Prostate Cancer.
Androgen deprivation therapy (ADT) is an established therapy for castration-sensitive prostate cancer …
Women’s Perceptions of Public Restrooms and the Relationships with Toileting Behaviors and Bladder Symptoms: A Cross-Sectional Study.
Because current knowledge about public restroom use and bladder health is limited, …
Proximal Hypospadias: Isolated Genital Condition or Marker of More?
The prevalence of endocrine/genetic anomalies among boys with proximal hypospadias is unknown. …