Latest Clinical Articles

A selection of the latest clinical articles from leading peer-reviewed medical journals. You can tailor the feed by selecting your specialty / sub-specialty in the menu above.

• Advances in fluorescence microscopy techniques to study kidney function.20th September 2020
  Fluorescence microscopy, in particular immunofluorescence microscopy, has been used extensively for the assessment of kidney function and pathology for both research and diagnostic purposes. The development of confocal microscopy in the 1950s enabled imaging of […]
• A very rare case of possible actinomycosis of the mandible from the Middle Ages.19th September 2020
  Documented cases of actinomycosis in archaeological skeletons are very rare, especially from Central Europe. Our contribution will help facilitate the differential diagnosis of this disease for other paleopathologists.This paper describes a pathological finding of the […]
• Stafne’s bone defects from Spain: report of four cases and brief archaeological literature review.19th September 2020
  To present for the first time in the north-western Spanish osteological record prevalence data on Stafne’s bone defect, to compare the results with those reported by other studies, and to increase the dataset for future […]
• Differences in perspectives of pediatricians on advance care planning: a cross-sectional survey.19th September 2020
  The increase in the number of pediatric patients with complex health conditions necessitates the application of advance care planning for children. Earlier, withdrawal of life-sustaining treatment was taboo in the medical society in South Korea […]
• Cost-utility analysis of extensile lateral approach versus sinus tarsi approach in Sanders type II/III calcaneus fractures.19th September 2020
  Extensile lateral approach had been recognized as the gold standard technique for displaced intra-articular calcaneus fractures (DIACFs) while sinus tarsi approach had been increasingly valued by surgeons and comparative clinical outcome was shown in both […]
• The underlying mechanism of partial anterior cruciate ligament injuries to the meniscus degeneration of knee joint in rabbit models.19th September 2020
  The diagnosis, treatment, and efficacy evaluation of anterior cruciate ligament (ACL) partial rupture remains controversial. This research aims to investigate the underlying mechanism of partial ACL injuries to the meniscus degeneration in the rabbit knee.Sixty […]
• Ultraviolet irradiation improves the hydrophilicity and osteo-conduction of hydroxyapatite.19th September 2020
  Treating a titanium or titanium alloy implant with ultraviolet (UV) light is known to improve its associated cell growth and osseointegration. However, little is known about the effect of UV irradiation on hydroxyapatite (HA), which […]
• Incidence and risk factors associated with postoperative stroke in the elderly patients undergoing hip fracture surgery.19th September 2020
  Stroke is one of the rare but devastating complications after hip fracture in the elderly. By far, there is still scarce data on postoperative stroke in elderly patients with hip fractures.This was a retrospective study […]
• Acceleration of bone union by in situ-formed hydrogel containing bone morphogenetic protein-2 in a mouse refractory fracture model.19th September 2020
  An enzymatic crosslinking strategy using hydrogen peroxide and horseradish peroxidase is receiving increasing attention for application with in situ-formed hydrogels (IFHs). Several studies have reported the application of IFHs in cell delivery and tissue engineering. […]
• Promoting functions of microRNA-29a/199B in neurological recovery in rats with spinal cord injury through inhibition of the RGMA/STAT3 axis.19th September 2020
  The prognostic and therapeutic potential of microRNAs (miRNAs) in spinal cord injury (SCI) has aroused increasing concerns. This study aims to research the functions of miR-29a/199B in the neurological function recovery after SCI and the […]
• Resveratrol alleviates the interleukin-1β-induced chondrocytes injury through the NF-κB signaling pathway.19th September 2020
  Osteoarthritis (OA) is a regular age-related disease that affects millions of people. Resveratrol (RSV) is a flavonoid with a stilbene structure with different pharmacological effects. The purpose of the experiment was to evaluate the protective […]
• Microdroplet and spatter contamination during phacoemulsification cataract surgery in the era of COVID-19.19th September 2020
  Determine phacoemulsification cataract surgery risk in a Covid-19 era.SARS-CoV-2 (Covid-19) transmission via microdroplet and aerosol generating procedures present a risk to medical professionals. As the most common elective surgical procedure performed globally; determining contamination risk […]
• Sociodemographic, behavioral, and medical risk factors associated with visual impairment among older adults: a community-based pilot survey in Southern District of Hong Kong.19th September 2020
  The last visual survey of older adults in Hong Kong was a district-level study in 2002, with no assessment of behavioral and medical risk factors for visual impairment (VI). Our objectives were to determine the […]
• Initial responsiveness to darbepoetin alfa and its contributing factors in non-dialysis chronic kidney disease patients in Japan.19th September 2020
  Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) is associated with cardiovascular events and poor renal outcome in patients with chronic kidney disease (CKD). This study aimed to investigate the initial responsiveness to darbepoetin alfa (DA) and its […]
• Intraperitoneal ampicillin treatment for peritoneal dialysis- related peritonitis with Listeria monocytogenes – a case report.19th September 2020
  Peritoneal dialysis (PD)-related peritonitis is a rare but serious complication and is associated with increased morbidity and mortality rates. It is most commonly caused by Staphylococcus aureus or Staphylococcus epidermidis, but infection with Listeria monocytogenes […]
• Protective effects of DPP-4 inhibitor on podocyte injury in glomerular diseases.19th September 2020
  Dipeptidyl peptidase-4 (DPP-4) is a serine protease that inhibits the degradation of glucagon-like peptide 1. DPP-4 inhibitors are used worldwide to treat type 2 diabetes mellitus and were recently shown to have pleiotropic effects such […]
• Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians.19th September 2020
  Calciphylaxis is a rare condition usually seen in patients with end-stage renal disease. Pain is a hallmark of this condition and can be extremely difficult to control. Anecdotal data suggests that pain management in calciphylaxis […]
• Membranous nephropathy in patients with HIV: a report of 11 cases.19th September 2020
  Membranous nephropathy (MN) has been recognized to occur in patients with human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. The prevalence of phospholipase A2 receptor (PLA2R)-associated MN in this group has […]
• Acute Kidney Injury and Risk of CKD and Hypertension after Pediatric Cardiac Surgery.19th September 2020
  The association of AKI after pediatric cardiac surgery with long-term CKD and hypertension development is unclear. The study objectives were to determine whether AKI after pediatric cardiac surgery is associated with incident CKD and hypertension.This […]
• Effect of Endoscope Sinus Surgery on Pulmonary Function in Cystic Fibrosis Patients: A Meta-Analysis.19th September 2020
  The objective of this study was to quantify the effect of endoscopic sinus surgery on pulmonary function in patients with cystic fibrosis and chronic rhinosinusitis.The PubMed, MEDLINE, Cochrane Library, and Embase databases were searched for […]
• Hey Siri: How Effective are Common Voice Recognition Systems at Recognizing Dysphonic Voices?19th September 2020
  Interaction with voice recognition systems, such as Siri™ and Alexa™, is an increasingly important part of everyday life. Patients with voice disorders may have difficulty with this technology, leading to frustration and reduction in quality […]
• Knowledge of sepsis risk and management among dental professionals in Wales: a service evaluation.19th September 2020
  Aims Sepsis is a significant medical condition. This service evaluation aimed to investigate the current level of knowledge, confidence and educational requirements regarding sepsis among dental professionals in Wales.Design A convenience-sampled, self-administered electronic questionnaire.Setting All […]
• Combined inferior alveolar nerve block anaesthesia and local infiltration anaesthesia in extraction of impacted mandibular third molars: a randomised controlled trial.19th September 2020
  Aim To compare the anaesthetic effect of combination of inferior alveolar nerve block anaesthesia and local infiltration anaesthesia with nerve block anaesthesia techniques in the extraction of mandibular third molars.Materials and methods One hundred and […]
• A risk score for postoperative nausea and/or vomiting in women undergoing cesarean delivery with intrathecal morphine.19th September 2020
  Postoperative nausea/vomiting affects up to 80% of parturients undergoing cesarean delivery, but there is a lack of obstetric-specific risk-prediction models. We performed this study to identify postoperative nausea/vomiting risk factors in parturients undergoing cesarean delivery, […]
• Hospital attendance and admission trends for cardiac diseases during the COVID-19 outbreak and lockdown in Greece.19th September 2020
  The coronavirus disease 2019 (COVID-19) outbreak, along with implementation of lockdown and strict public movement restrictions, in Greece has affected hospital visits and admissions. We aimed to investigate trends of cardiac disease admissions during the […]
• Dental care management during the COVID-19 outbreak.19th September 2020
  The level of preparedness of the healthcare system plays an important role in management of coronavirus disease 2019 (COVID-19). This study attempted to devise a comprehensive protocol regarding dental care during the COVID-19 outbreak.Embase, PubMed, […]
• Impact of interleukin-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and antibody responses in patients with COVID-19: A prospective cohort study.19th September 2020
  The virological and immunological effects of the immunomodulatory drugs used for COVID-19 remain unknown. We evaluated the impact of interleukin (IL)-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and the antibody response in patients with […]
• Continuous electroencephalography characteristics and acute symptomatic seizures in COVID-19 patients.19th September 2020
  As concerns regarding neurological manifestations in COVID-19 (coronavirus disease 2019) patients increase, limited data exists on continuous electroencephalography (cEEG) findings in these patients. We present a retrospective cohort study of cEEG monitoring in COVID-19 patients […]
• Incidence of anxiety in epilepsy during coronavirus disease (COVID-19) pandemic.19th September 2020
  The coronavirus disease 2019 (COVID-19) pandemic has affected people globally, and people with chronic diseases are suffering more in maintaining their mental and physical health.This cross-sectional, case-control study assessed the anxiety level in people with […]
• Network pharmacology analysis of the therapeutic mechanisms of the traditional Chinese herbal formula Lian Hua Qing Wen in Corona virus disease 2019 (COVID-19), gives fundamental support to the clinical use of LHQW.19th September 2020
  The traditional Chinese Medicine (TCM) herbal formula Lian Hua Qing Wen (LHQW) improves the results of COVID-19 treatment. Three very recent studies analyzed with network pharmacology some working mechanisms of LHQW. However, we used more […]
• Qualitative study of the psychological experience of COVID-19 patients during hospitalization.19th September 2020
  Coronavirus disease 2019 (COVID-19) continues to spread across the globe, but patient experiences are rarely documented.To explore the psychology of COVID-19 patients during hospitalization.A phenomenological and robust sampling approach was employed. Sixteen patients admitted to […]
• Neurosurgical services in the Northern Zone of Sarawak in Malaysia: The way forward amid COVID-19 pandemic.19th September 2020
  The novel coronavirus disease 2019 (COVID-19) pandemic has set a huge challenge to the delivery of neurosurgical services including the transfer of patients. We aimed to share our strategy in handling neurosurgical emergencies at a […]
• Coronavirus Disease 2019 Population-based Prevalence, Risk Factors, Hospitalization, and Fatality Rates in Southern Brazil.19th September 2020
  To assess population-based prevalence, risk factors, hospitalization, and infection fatality rates (IFR) associated with COVID-19.We conducted two household surveys among the non-institutionalized adult population from May 30 to June 17, 2020, in Lajeado, an 84,000-inhabitants […]
• COVID-19 Infection Among Healthcare Workers in a National Healthcare System: the Qatar Experience.19th September 2020
  Our aim was to determine the prevalence of COVID-19 infection in healthcare workers (HCW) in a national healthcare system and to understand the risk factors for infection.The study was conducted at Hamad Medical Corporation in […]
• Delay in diagnosis of pulmonary tuberculosis in The Gambia, West Africa: a cross-sectional study.19th September 2020
  To investigate the pattern of tuberculosis (TB) care initiation and risk factors for TB diagnostic delay in The Gambia.In this cross-sectional study, adult patients diagnosed with pulmonary TB (pTB) in public facilities in the Greater […]
• Viable SARS-CoV-2 in the air of a hospital room with COVID-19 patients.19th September 2020
  Because detection of SARS-CoV-2 RNA in aerosols but failure to isolate viable (infectious) virus are commonly reported, there is substantial controversy whether SARS-CoV-2 can be transmitted through aerosols. This conundrum occurs because common air samplers […]
• Preparedness of African palliative care services to respond to the COVID-19 pandemic: A rapid assessment.19th September 2020
  Palliative care is an essential component of the COVID-19 pandemic response, but is overlooked in national and international preparedness plans. The preparedness and capacity of African palliative care services to respond to COVID-19 is unknown.To […]
• Cardiopulmonary Resuscitation in patients with suspected or confirmed Covid-19. A Consensus of the Working group of the Cardiopulmonary Resuscitation of the Hellenic Society of Cardiology.19th September 2020
  The unprecedented for modern medicine pandemic caused by the SARS-COV-2 virus (“coronavirus”, Covid-19) creates in turn new data on the survival of cardiac arrest victims, but mainly on the safety of Cardiopulmonary Resuscitation (CPR) providers. […]
• In-flight transmission of COVID-19 on flights to Greece: an epidemiological analysis.19th September 2020
  The emergence in China in late 2019 and subsequent progression of a pandemic of a respiratory disease named coronavirus disease 2019 (COVID-19) was highly facilitated by international travel. We present 5 cases of probable in-flight […]
• Value of swab types and collection time on SARS-COV-2 detection using RT-PCR assay.19th September 2020
  Low viral load from patients infected with SARS-CoV-2 during infection late stage easily lead to false negative nucleic acid testing results, thus having great challenges to the prevention and control of the current pandemic. In […]
• Disinfection of gloved hands during the Coronavirus outbreak (COVID-2019).19th September 2020
  In the current pandemic situation, glove disinfection is a process that can be used to care for the same patient or when removing personal protective equipment. For this reason, it is necessary to check compatibility […]
• The conundrum of human immune system “senescence”.19th September 2020
  There is a great deal of debate on the question of whether or not we know what ageing is (Ref. Cohen et al). Here, we consider what we believe to be the especially confused and […]
• Association of Body mass index (BMI) with Critical COVID-19 and in-hospital Mortality: a dose-response meta-analysis.19th September 2020
  The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented health crisis to the entire world. As reported, the body mass index (BMI) may play an important role in COVID-19; however, this still remains unclear. The […]
• Hypercytokinemia in COVID-19: Tear cytokine profile in hospitalized COVID-19 patients.19th September 2020
  The aim of this study is to analyze the concentrations of cytokines in tear of hospitalized COVID-19 patients compared to healthy controls. Tear samples were obtained from 41 healthy controls and 62 COVID-19 patients. Twenty-seven […]
• Nailfold capillaroscopy findings in patients with coronavirus disease 19: Broadening the spectrum of covid-19 microvascular involvement.19th September 2020
  Increasing evidence points to endothelial dysfunction as a key pathophysiological factor in coronavirus disease-2019 (COVID-19). No specific methods have been identified to predict, detect and quantify the microvascular alterations during COVID-19. Our aim was to […]
• Taming the cytokine storm: repurposing montelukast for the attenuation and prophylaxis of severe COVID-19 symptoms.19th September 2020
  As a result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, a clinical complication can arise that is characterized by a hyperinflammatory cytokine profile, often termed a ‘cytokine storm’. A protein complex (nuclear factor […]
• Management of pernio-like cutaneous manifestations in children during the outbreak of covid-19.19th September 2020
  During the outbreak of COVID-19 many pernio-like lesions have been increasingly reported. The aim of the study is to describe our management of these skin manifestations and to evaluate a possible correlation to SARS-CoV-2 infection.All […]
• Impact of Treatment with Renin-Angiotensin System Inhibitors on Clinical Outcomes in Hypertensive Patients Hospitalized with COVID-19.19th September 2020
  Concerns have been raised about the possible harmfulness of angiotensin-converter enzyme inhibitors (ACEi) and aldosterone receptor blockers (ARB) in patients with COVID-19. However, few data from a European population have been published, especially from hypertensive patients.To study the association […]
• Clinical characteristics of moderate and severe cases with COVID-19 in Wuhan, China: a retrospective study.19th September 2020
  With the outbreak of COVID-19 ongoing, this infectious disease has been posing a significant threat to public health. However, we are still relatively inexperienced on recognizing the clinical characteristics of severe COVID-19 and death cases. […]
• Seizure in patients with COVID-19.19th September 2020
  The purpose of the current study was to collect the data on the occurrence of seizures in patients with COVID-19 and to clarify the circumstances of the occurrence of seizures in these patients.All consecutive patients […]
• Abdominal CT in COVID-19 patients: incidence, indications, and findings.19th September 2020
  The purpose of this study was to evaluate the frequency, indications, and findings of abdominal CTs ordered in the initial evaluation of patients who had a positive COVID-19 test performed in our institution.Retrospective chart review […]
• Mobile ECMO in COVID-19 patient: case report.19th September 2020
  At July 25, 2020, WHO had recorded more than 16.1 million confirmed COVID-19 cases, 1% of them developed critical illness. These patients can experience rapid progression to profound hypoxemia and severe acute respiratory distress syndrome […]
• Balloon aortic valvuloplasty for urgent treatment of severe aortic stenosis during coronavirus disease 2019 pandemic: a case report.19th September 2020
  An 86-year-old man affected by severe aortic stenosis (AS) was referred to our institution owing to decompensated heart failure. Three months before, the patient was scheduled for transcatheter aortic valve implantation (TAVI), which was postponed […]
• The impact of COVID-19 pandemic on people with severe mental illness.19th September 2020
  The purpose of this review was to address the impact of the COVID-19 pandemic on people with severe mental illness.Given the psychosocial effects of the COVID-19 pandemic process and the vulnerability of individuals with mental […]
• STAT3 isoforms differentially affect ACE2 expression: A potential target for COVID-19 therapy.19th September 2020
  The SARS-coronavirus 2 is the aetiologic agent COVID-19. ACE2 has been identified as a cell entry receptor for the virus. Therefore, trying to understand how the gene is controlled has become a major goal. We […]
• Multiple Organ Injury on Admission Predicts In-Hospital Mortality in Patients with COVID -19.19th September 2020
  Multiorgan injury has been implicated in patients with coronavirus disease 2019 (COVID-19). We aim to assess the impact of organ injury (OI) on prognosis according to the number of affected organs at admission.This is a […]
• SARS-CoV-2 molecular testing for the diagnosis of COVID-19: One test does not fit all.19th September 2020
  We read with interest the study by Chu et al., in which SARS-CoV-2 was detected in only 30 of 54 (56%) of healthcare workers (HCW) by real-time reverse transcription polymerase chain reaction (RT-PCR) in upper […]
• Safety of non-tumor necrosis factor-targeted biologics in the COVID-19 pandemic.19th September 2020
  Coronavirus disease 2019 (COVID-19) is a respiratory tract infection (RTI) caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which has been spreading worldwide. This article is protected by copyright. All rights reserved. Get […]
• Clinical outcomes of patients with COVID-19 and HIV coinfection.19th September 2020
  Patients with Human Immune Deficiency Virus (HIV) infection may be at an increased risk for morbidity and mortality from the Coronavirus disease-2019 (COVID-19). We present the clinical outcomes of HIV patients hospitalized for COVID-19 in […]
• The Pediatric Solid Organ Transplant Experience with COVID-19: An Initial Multi-Center, Multi-Organ Case Series.19th September 2020
  The clinical course of COVID-19 in pediatric solid organ transplant recipients remains ambiguous. Though preliminary experiences with adult transplant recipients have been published, literature centered on the pediatric population is limited. We herein report a […]

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